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12 Cards in this Set
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Occur in the left atria;
can be associated with genetic syndrome of skin lesions, overactivity of the endocrine system, and this lesion; mean age is 50 years, more frequently in women Carney complex in 7% these cases are more common in the RA. Histo: spindled cells and vessels in loose, myxoid stroma.. May contain hemorrhage. Immuno: Calretinin in 75%, CD31/34 |
Myxoma
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L Q 1
Carney complex in 7% these cases are more common in the RA. Histo: spindled cells and vessels in loose, myxoid stroma.. May contain hemorrhage. Immuno: Calretinin in 75%, CD31/34 |
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Severe and rapid fatal disorder of young, healthy adults who present with congestive heart failure
associated with other autoimmune disorders mean survival is 5.5 months Can recur after transplantation Whites>blacks Histology: Diffuse mixed inflammatory infiltrate, geographic necrosis. Giant cells without granulomas* |
Idiopathic giant cell myocarditis
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Histology: Diffuse mixed inflammatory infiltrate, geographic necrosis. Giant cells without granulomas*
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most common cause of sudden cardiac death in young people (<30), although can occur in any age
Diastolic dysfunction, impair left ventricular outflow are cause of death Histo: myocyte hypertrophy and disarray 2. Gene mutation? |
Hypertrophic cardiomyopathy
2. can be caused by over 400 mutations, but b myosin is most common (35%) |
can be caused by over 400 mutations, but b myosin is most common (35%)
Histo: myocyte hypertrophy and disarray |
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Can be caused by primary, secondary, age-related, and hereditary forms of heart disease
Causes restrictive cardiomyopathy Hsito- pink amorphous material Stain: congo red- polarized light Causes: 1. Primary- ? 2. Secondary-? 3. Senile- ? |
Cardiac amyloidosis
1. Primary- plasma cell dyscrasia- monoclonal light chains 2. Secondary- inflammatory 3. Senile- prealbumin |
Hsito- pink amorphous material
Stain: congo red- polarized light Primary- plasma cell dyscrasia- monoclonal light chains Secondary inflammatory Senile- prealbumin |
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Commonly on the aortic valve, these lesions account for 3/4 of all valvular tumors
Resemble Lambl excrescenses look like sea anemone when placed in water Histo: avascular, composed of fine papillae lined by endothelium Stain- elastic highlight that component |
papillary fibroelastoma
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Histo: avascular, composed of fine papillae lined by endothelium
Stain- elastic highlight that component |
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kids with ventricular septal mass, can be symptomatic.
Family h/c basal cell CA. Assc. with Gorlin Syndrome Gross: hard, rubbery mass, may have calcifications Micro: fibroblasts/myofibroblasts, surrounded my collagen that stains with trichrome Immuno- cells are SMA/vimentin + Gorlin syndrome caused by mutation in PTC gene. |
cardiac fibroma
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pt with recent history of new medication or transplant. Typically antibiotic or anticonvulsants.
Micro: no necrosis-lots of eos and pooly formed granulomas |
hypersensitivty myocarditis
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child with well-circumscribed tumor, maybe multiple
Family history- related to tuberous sclerosis (50% of TS patients) may regress spontaneously most common heart tumor in kids Gross:overgrowths of myocardium, ave up to 3 cm micro:spider cells-vaculoated 1. Genetics :what are the MC mutations? Are B9 Immuno:vimentin, desmin, actin +. focal HMB 45 |
rhabdomyoma
1.Gen: mutations in TSC1 and TSC2. |
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central and south american with development of heart failure and arrythmias.
can recur with transplant due to immunosuppression Micro:organisms can be seen in hypertrophied myocytes Caused by T. cruzi |
Chagas' disease
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middle aged black woman with dilated or restrictive cardiomyopathy
20-30% of system disease presents with cardiac features, may need transplantation Gross: Micro: non-caseating granulomas with giant cells |
cardiac sarcoidosis
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sudden death in a Italian person with family history of arrythmia and heart failure.
Is autosomal dominant in 50% Rare (3% of sudden death) Gross: ventricluar replacement by fatty tissie Micro same |
Arrythmogenic cardiomyopathy
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previously heathly person with sudden onset of right heart failure.
Gross: dilated heart X-Linked disease |
Familial dilated cardiomyopathy
Also caused by viral entites (coxackie) and alcohol use. |
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