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8 Cards in this Set
- Front
- Back
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Define chronic pain. |
Pain that persists even after the damaged tissue has been healed. Usually due to neural problems. |
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Compare and contrast nociceptive versus neuropathic pain. |
Nociceptive pain - physiological response to tissue damage Neuropathic pain - not the result of tissue damage but changes in the nervous system |
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Describe how chronic pain can arise from damage to the periphery, spinal cord and brain. |
Periphery - mutation in SCN9A Na channel gene that causes Na leckage; Na leaks more often and nociceptors fire APs more often (sometimes even random) Spinal cord - C-fibers atrophy, and A-beta fibers project into the superficial dorsal horn, innervating the spinothalmic tract; touch becomes pain Brain - hightened insula activity |
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Define hyperalgesia. What causes this? |
an increased response to a painful stimulus mutation in SCN9A gene that results in Na leakage; nociceptors fire AP more frequently and at lower thresholds |
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Describe hyperalgesia that results from focal burns. What is the difference between sensitivity to mechanical versus thermal stimuli? |
The burned area and even areas around the burn have a heightened response to mechanical stimulus (pain). Only the burned area has a heightened response to thermal stimuli |
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How do mutations at the SCN9A impact pain perception |
Na leakage; nociceptors fire APs more frequently and have lower thresholds |
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What is allodynia? What causes it? How is it different from hyperalgesia? |
an painful response to a stimulus that should not be painful when a-beta fibers in the spinal cord begin to grow into the superficial dorsal horn, they have the capability to innervate the spinothalmic tract (the pain pathway) hyperalgesia is just a heightened response to a stimulus that should be painful itself |
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How does chronic pain impact the frontal cortex? What are the consequences on behaviour? |
decreases grey matter density in the PFC poorer decision making, rationing, judgement, etc.. chronic pain also affects mood |
