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11 Cards in this Set
- Front
- Back
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Recurrent
4-72 hr Pain is (have 2 of 5 symptoms) Unilateral, pulsating, intensity is moderate to severe, aggravated by movement Nausea, photophobia, photophonia |
Migraine without aura
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Recurrent disorder manifesting in attacks of reversible focal neurological symptoms that usually develop gradually over 5-20 min and last for less than 60 min.
Recurrent 4-72 hr Pain is (have 2 of 5 symptoms) Unilateral, pulsating, intensity is moderate to severe, aggravated by movement Nausea, photophobia, photophonia |
migraine WITH aura
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Complex of neurological symptoms that occur before migraine HA
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aura
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most common aura
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Visual auras are the most common
Photopsia (lights, lighting flashes) Sensory aura is next common Motor weakness & aphasia are least common |
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Estrogen
Genetics Environment Temperature Barometric pressure Excessive afferent stimulation Behavioral factors Diet Stress Sleep deprivation Physical exertion Head trauma Drugs that deplete 5HT |
migraine triggers
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Extracranial arterial vasodialation
Extracranial neurogenic inflammation Peripheral sensitization Central sensitization |
pathophysiology of migraine
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Where is the pain in a migraine?
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Blood Vessels in supratentorial dura mater
Extracranial arterial inflammation |
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Vasodilation of meningeal BV activates CN???
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Vasodilation of meningeal BV activates CN V
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Release of ???
from nerve terminals* causes more dilation of BV |
Release of vasoactive peptides
from nerve terminals* causes more dilation of BV |
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With drugs, why does migraine pain persist & intensify?
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CENTRAL SENSITIZATION
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sumatriptan
mechanism of action? |
immitrex migraine medicine
mechanism: 5-HT receptor agonist |
