Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
27 Cards in this Set
- Front
- Back
|
What are the agents used for acute tx of headache? |
1. Triptans 2. Ergot alkaloids 3. Oxygen |
|
|
What are the agents used for prophylactic tx of HA? |
1. Topiramate 2. Cyproheptadine 3. Propranolol |
|
|
What are the triptans? |
1. Sumatriptan 2. Naratriptan 3. Rizatriptan 4. Zolmitriptan |
|
|
What is the MOA of triptans? |
1. Affinity for 5-HT1 receptors 2. Constriction of dilated cranial vessels outside CNS |
|
|
What is the metabolism of triptans? |
1. MAO-A 2. CYP3A4 or CYP1A2 |
|
|
How are triptans excreted? |
1. Urine |
|
|
What are the adverse effects of triptans? |
1. Nausea 2. Fatigue 3. Dizziness 4. Drowsiness |
|
|
What are the contraindications for triptans? |
1. Don't use w/ MAOIs 2. Careful with use of cimetidine or OCs |
|
|
What is the mechanism of action of ergotamine and dihydroergotamine? |
1. Agonist of 50HT1B and 5-HT1D 2. Partial agonist of a1 and a2 3. Reduces amplitude and pulsation of cranial arteries 4. Vasoconstricts
|
|
|
What is the effect of dihydroergotamine on D1 and D2 receptorsS? |
1. Agonist |
|
|
What is the elimination rate of erogtamine vs. dihydroergotamine? |
1. Dihydroergotamine is eliminated more rapidly |
|
|
What is the clinical use of ergotamine and dihydroergotamine? |
1. Migraine 2. Cluster headaches |
|
|
What are the adverse effects of ergotamine and dihydroergotamine? |
1. N/V 2. Diarrhea 3. Paresthesias of extremities 4. Angina-like ssx |
|
|
What are the precautions for ergotamine and dihydroergotamine? |
1. Chronic overdose leads to vasoconstriction and gangrene 2. Rebound vasoconstriciton 3. Pregnancy 4. Don't use with BB |
|
|
What is the MOA of topiramate? |
1. Increases GABA A-releated Cl currents 2. Inhibits neuronal firing |
|
|
What is the MOA of cyproheptadine? |
1. 5-HT2 antagonist 2. Weak H1 antagonist 3. Weak anticholinergic |
|
|
What is the clinical use of cyproheptadine? |
1. Prophylaxis for children in tx of migraines |
|
|
How is isometheptene used? |
1. Combine with acetaminophen and dichloralphenazone in combo tx 2. Used to abort or after aura has started |
|
|
What are the contraindications of isometheptene? |
1. HTN 2. Heart disease 3. PVD |
|
|
What are the adverse effects of isometheptene? |
1. Drowsiness 2. Dizziness 3. Weakness 4. Palpitations |
|
|
What is the MOA of isometheptene? |
1. Sympathomimetic vasoconstrictor |
|
|
What is the use of NSAIDs in the tx of HA? |
1. Mild to moderate pain 2. Beneficial in tension HA 3. Can be used with triptans to tx tension HA |
|
|
What are the sedatives? |
1. Butalbital 2. Meprobamate 3. Benzodiazepines |
|
|
What is the use of sedatives in the tx of HAs? |
1. Tension HAs 2. Migraines HAs |
|
|
What is the use of antidepressants in the tx of HA? |
1. Prophylaxis only |
|
|
What is the use of lithium? |
1. Prophylactic tx of choric and episodic cluster headaches |
|
|
What is the use of corticosteroids? |
1. Acute headaches |
