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3 Cards in this Set
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Oral mucosa, diagnosis? |
Lichen planus - Band-like submucosal infiltrate of lymphocytes with destruction of basal layer of surface epithelium. Can have degenerating keratinocytes (Civatte bodies) |
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Antibodies to what is implicated in pemphigus vulgaris?
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Desmogleins 1 and 3, affecting suprabasal epithelium (Tombstone appearance)
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How is cicatricial or mucous membrane pemphigus different from pemphigus vulgaris?
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Oral mucosa always involved in cicatricial pemphigus, bullae are not flaccid and rupture with scarring, antibodies target basement membrane and IF shows linear staining with IgG and C3
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