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10 Cards in this Set
- Front
- Back
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What facilitates antigen uptake in GI tract?
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M cells
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What do mucosal-derived lymphocytes express to return?
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Alpha4Beta7 integrin
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Where does 70-80% of Ig production take place?
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GI tract
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Secretory IgA travels through what two cell types?
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IgA plasma cells and mucosal epithelial cells
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How can overcome or prevent antigen response?
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Provide orally
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What are the regulatory T cell usages in IBD?
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With Th1 cells, can protect against inflammation
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What role does M2 play in GI tract?
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phagocytose and kill
(not pro-inflammatory) |
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What are more anti-inflammatory cytokines?
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IL-10, TGF Beta, IL-1Ra, IL-11, IFN alpha/Beta, PGE, PGJ
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4 main factors of intestinal immune response
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-exclude dietary/microbial antigens
-activate and homing to return -Tolerance with stim of IgA and reg T cells -Controlled inflammatory responses |
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What two immunity changes can trigger Crohn's disease?
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Defective innate immunity, mucosal barrier function
Overly aggressive T cell responses (lack of tolerance) |
