Hdi Virology

Front 1

Which are the main DNA viruses?

Back 1

* Herpes (HSV, Varicella, EBV)
* Hepadna (HepB)
* Adeno
* Papavo(HPV)
Parvo
Pox
(y)

Front 2

What is another name for the orthomycovirus?

Back 2

influenza

Front 3

Which viruses contains the HA and NA surface proteins? What do these proteins so?

Back 3

- orthomycovirus
- paramyxoviridae
- Mumps
HA (hemagglutin) binds to sialic acid receptors and permits absorption into host cell
NA (neuraminidase) disrupts neuraminic acid in mucosal epithelial cells and thus disrupts barrier exposing sialic acid binding site for HA to attach

Front 4

HA direct effect on host?

Back 4

- Primary pnemonia,
- high fever, chillds, malaise and myalgias
- Dry cough, sorethroat, rhonorrhea (runny nose)

Front 5

Which infection increases the chance of an immunocompromised host of contracting secondary bacterial pneumonia from staph aureus, H. influenze, or strep pneumo?

Back 5

Orthomycovirus

Front 6

Which organisms with HA and NA proteins cause larynx or URT infections in children that lead to swelling and airway narrowing --> stridor wheeze, barking cough?

Back 6

Parainfluenza

Front 7

Which organism possess F protein which causes formation of multinucleated giant cells (syncytial cells) and cause pneumonia?

Back 7

Repiratory syncytial virus (RSV)

Front 8

Which virus w HA, NA and F protein cause URTI that progressed to reginoal lymph node replication which can spread to parotid gland, testes, (orchitis), meninges and encephalus?

Back 8

Mumps virus

Front 9

Which virus possesing HA and F proteins replicates in resp mucous membranes or conjunctival membranes?

Back 9

Measles virus (rubeola)

Front 10

Which virus causes Kloplik spots (mouth) that progress to a rash from face to feet?

Back 10

Measles

Front 11

Which virus can cause prodrume (conjunctivitis, welling of eyelid, photophobia, fever, hacking cough, rhinitis, and maliase) followed by disemination?

Back 11

Measles

Front 12

Which virus is transmitted via mosquito and replicates in the langerhans cells (skin)?

Back 12

West nile virus

Front 13

Which virus if diseminated via lymph nodes can cause infection of multiple organs, fever, encephalitis --> sever encephalitix --> death OR can be asymptomatic in most cases?

Back 13

West nile virus

Front 14

Which virus is tramitted parenterally and infects hepatocyte causing their death?

Back 14

Hep C virus

Front 15

Which virus kills hepatocytes both directly and indirectly via CTLs?

Back 15

Hep C virus

Front 16

Which organisms can cross the placenta?

Back 16

TOxoplama gondii
Rubella
Cytomegalovirus
HErpes, HIV
Syphilis

Front 17

Which virus is consider the "3 day measels"?

Back 17

Rubella

Front 18

Which virus infects the nasopharynx, replicates in lymphnodes and leads to maculopapular rash on face to extremities progressing to arthritis (Ab complexes)?

Back 18

Rubella

Front 19

Which virus can cause congentital defects like microcephaly, patent DA, PA stenosis, or cataract is passed to fetus?

Back 19

Rubella

Front 20

Which virus is trasmitter fecal orally and infects villus cells of the proximal small intestine?

Back 20

Rotavirus

Front 21

Which virus replicates within cells of small intestine and impair absorption of CHO and otehr nutrients --> vomitting, watery diarrhea?

Back 21

Rotavirus

Front 22

Which virus is transmitted through animal bite and binds AchR allowing entry into peripheral nerves?

Back 22

Rhabdovirus (rabies)

Front 23

Which virus can invade CNS and cause Negri bodies (cyplasmic inclusions) to form --> cranial palsies --> dysphagia, agitation, seizures
--> painful phayngeal contractoin --> foaming of mouth?

Back 23

Rhabdovirus (rabies)

Front 24

Which virus contaminates food and water and casues inflammatino of fmall intestine, gastroenteritis, vomitting and diarhea?

Back 24

Norwalk Virus

Front 25

Which virus is tranmitted FO, infects mucosal epithelium of GI and leads to acute hepatitis, jaundice?

Back 25

Hep A virus

Front 26

Which virus is the "common cold"?

Back 26

Rhinovirus

Front 27

Which virus has large human reservoir and bind ICAM in URT epithelial cells --> extends locally without killing cells --> sinusitis, ottis media possible

Back 27

Rhinovirus

Front 28

Which virus is tranmitter FO, infects mucosal epithelial cells and can cause herpangina, red oropharynx vesicles, heart and pleural surface infection, small ternder lesions on hands, mouth, feet and buttocks?

Back 28

Coxakie virus

Front 29

Which virus is tranmitter FO and infect small intestine and pharynx epithelium (sore throat) and can enter peripheral nerves in a retrograde fashion eventually causing paralysis, resp insuficiency (due to motor neuron lyses)?

Back 29

Poliovirus

Front 30

Which types of cells can the HIV virus infect?

Back 30

CD4+ cells including Th cells in blood and macrophages in epidermis.

Front 31

Where does the HIV virus replicate?

Back 31

spleen and lymphoid organs

Front 32

Which organisms causes monnucleosis like symptoms?

Back 32

HIV

Front 33

What is the clinical latency period of HIV?

Back 33

7-10years

Front 34

Why is tehere CD4 depletion dollowing reactivation of HIV virus?

Back 34

1. immune attack on infected CD4 cells by CTLs
2. Cell lysis from extensive viral binding
3. Syncytia formation bw infected cell with uninfected cell (via 120-CD4 interaction) allowing HIV viron to kill multiple Th cells by infecting only one.

Front 35

When is HIV infections in AIDs?

Back 35

<200 CD4 cells/ ul

Front 36

What are some opportunistic infections common to AIDs?

Back 36

- P. jirovecii pneumonisr
- M. TB
- M. AI
- Karposi's sarcoma
- Candida
- dissminated HSV
- CMV
- histoplsmosis
- toxoplasmosis

Front 37

What are common CF of AIDs patinet with CD4 < 50?

Back 37

- dimentia
- neuropathy
- encephalopathy

Front 38

What proteins on HIV virus interact with Th and macrophages?

Back 38

gp 120 (glycoprotein) binds CD4, CXCR4 and CCR5 on Tcells and M0

Front 39

Which proteins on HIV virus mediates viral-cell fusion and syncytia formation?

Back 39

gp 41 (env)

Front 40

What are the constiuational symptoms of HIV and at what CD4 count do they arise?

Back 40

Proceed clinical latency.
CD4 bw 200-400
- Fever
- weight loss
- night sweats
- adenopathy

Front 41

Where does the HIV virus replicate?

Back 41

spleen and lymphoid organs

Front 42

Which organisms causes monnucleosis like symptoms?

Back 42

HIV

Front 43

What is the clinical latency period of HIV?

Back 43

7-10years

Front 44

Why is tehere CD4 depletion dollowing reactivation of HIV virus?

Back 44

1. immune attack on infected CD4 cells by CTLs
2. Cell lysis from extensive viral binding
3. Syncytia formation bw infected cell with uninfected cell (via 120-CD4 interaction) allowing HIV viron to kill multiple Th cells by infecting only one.

Front 45

When is HIV infections in AIDs?

Back 45

<200 CD4 cells/ ul

Front 46

What are some opportunistic infections common to AIDs?

Back 46

- P. jirovecii pneumonisr
- M. TB
- M. AI
- Karposi's sarcoma
- Candida
- dissminated HSV
- CMV
- histoplsmosis
- toxoplasmosis

Front 47

What are common CF of AIDs patinet with CD4 < 50?

Back 47

- dimentia
- neuropathy
- encephalopathy

Front 48

What proteins on HIV virus interact with Th and macrophages?

Back 48

gp 120 (glycoprotein) binds CD4, CXCR4 and CCR5 on Tcells and M0

Front 49

Which proteins on HIV virus mediates viral-cell fusion and syncytia formation?

Back 49

gp 41 (env)

Front 50

What are the constiuational symptoms of HIV and at what CD4 count do they arise?

Back 50

Proceed clinical latency.
CD4 bw 200-400
- Fever
- weight loss
- night sweats
- adenopathy

Front 51

Which virus infects squamous epithlial cells and can cause vaculication (warts), benign grwoth (carcinomas: cerivical, squamous cell, or laryngeal)?

Back 51

Papovavirus (HPV)
Think triple O
O DNA (circular)
O warts
O cervical cancer

Front 52

Which virus is transmitted via blood, sexual contact or transplacentally anc causes aute hepatitis, cirrhosis OR carrier asymptomatic? Also increased risk for hepatocellular carcinoma.

Back 52

Hep B

Front 53

What do HBV and HCV have in common?

Back 53

- blood tranmission
- chronic carrier status
- cirrohsis
- hepatocellular carcinoma

Front 54

Which virus is transmitted via saliva and invades mucose membranes causing a local infection in the mouth (gingicastomatitis), eyes (keratoconjuntivitis)?

Back 54

HSV-1

Front 55

Which virus is transmitted via saliva and invades sensory nerve endings and infects trigeminal nerve, lumbosacral nerve and cranial nerve leading to herpetic lavialis, encephalitix, blindness?

Back 55

HSV-1 and 2
HSV 1 - above the waist (eyes, brain and mouth lesions)
HSV 2 - below the waist (genical lesions)

Front 56

Which virus causes chicken pox?

Back 56

Varicella Zoster virus

Front 57

Which virus tranmitted through resp secretios or ruptured vesicles and have a 2week incubation period?

Back 57

Zoster

Front 58

Which virus stays latent post infection in sensory ganglion cell bodies?

Back 58

Zoster

Front 59

Which virus causes rash over sensory dermatome?

Back 59

Zoster (shingles)

Front 60

Which virus is the "kissing virus"?

Back 60

EBC

Front 61

Which virus infects the oropharynx and lead to mononuceosis symptoms?

Back 61

EBV

Front 62

Which virus increases chance for burkitts lymphoma and nasopharyngeal cancer?

Back 62

EBV

Front 63

What are mononucleosis symptoms?

Back 63

- flu like symptoms
- lymph node enlarged
- spleen enlarged
- painful phayngitis