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9 Cards in this Set
- Front
- Back
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Which cytokine induces a Th0 cell to become a Th1?
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IL-12.
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What cytokines does an activated Th1 cell release?
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IL-2, INF-gamma.
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What is the function of IL-2?
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It is a growth factor for CD8, Th1, and T-reg cells.
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What is the function of INF-gamma?
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Key cytokine of the Th1 response, that also suppresses the Th2 response.
Activator of macrophages via the Th1 reaction. Upregulate MHC II's on cell surface. |
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What is a T-cell response that is considered "heresy" and how does it relate to organ transplants?
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T-cells that kill without the use of MHC presentation. A mechanism that is not understood, but observed in transplant rejections.
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What is the role of CD4 in the immune response?
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Activate and recruit macrophages, and stimulate Ag-specific Ab production from B-cells.
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Which epitopes would you want to target with monoclonal Ab's to suppress the immune response and increase organ transplant tolerance?
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CD4 (activate macrophages and produce Ab's), CD8 (cytotoxic T cell production); IL-2, IL-12, INF-gamma (Th1).
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The presence of which cytokines would be an encouraging sign in a tumor biopsy?
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INF-gamma and IL-2 because they indicate the presence of CD8 cells that may attack the tumor cells.
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Would be a bad sign in a tumor biopsy?
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Presence of CD4,25 T-reg cells (FoxP3) that may help the tumor survive.
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