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10 Cards in this Set

  • Front
  • Back
Which cytokines are associated with B-cell proliferation?
IL-4, IL-13.
What cytokine is always associated with eosinophils?
Why would a patient with worms have IgG in serum, and not just IgE?
IgE binds to big worms and IgG is released by the late secondary adaptive, cytotoxic immune response in trying to kill it.
What type of FcR crosslinking occurs in an allergic reaction?
Fc-E-R that are "armed" with IgE's.
What is the problem with allergies?
Too many IgE's are formed, which bind to allergic MHC II antigen presentation, which bind to Fc-E-R's, which recruit and activate mast cells, which will degranulate histamine and other vasoactive substances to the gut, skin, and lungs.
Describe mechanism of treatment of allergens using injection of the allergen extract.
Repeated exposure to the allergen will expand the CD4,25 T-reg cells that will reroute the immune reaction away from Th2 and toward Th1. This will result in production of IgG's to clear the antigen, rather than excess IgE production.
Describe RAST testing.
Allergen in solid phase is exposed to IgE from patient serum. After washing, radio-labeled anti-IgE was added and will attach to IgE if it bound to the allergen. Radioactivity is measured. The allergen is known and is used to predict allergies.
What tests could be performed on the patient's serum to clarify the reaction?
RAST for Anti-IgE and ELISA for Anti-IgG.
What is the only way to treat an immediate, anaphylactic allergic reaction?
Epinephrine injection.
How might the use of a specific monoclonal anti-IgE be useful as treatment?
Binds to IgE's which are specific to certain allergen epitopes.