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10 Cards in this Set
- Front
- Back
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Which cytokines are associated with B-cell proliferation?
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IL-4, IL-13.
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What cytokine is always associated with eosinophils?
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IL-5.
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Why would a patient with worms have IgG in serum, and not just IgE?
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IgE binds to big worms and IgG is released by the late secondary adaptive, cytotoxic immune response in trying to kill it.
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What type of FcR crosslinking occurs in an allergic reaction?
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Fc-E-R that are "armed" with IgE's.
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What is the problem with allergies?
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Too many IgE's are formed, which bind to allergic MHC II antigen presentation, which bind to Fc-E-R's, which recruit and activate mast cells, which will degranulate histamine and other vasoactive substances to the gut, skin, and lungs.
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Describe mechanism of treatment of allergens using injection of the allergen extract.
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Repeated exposure to the allergen will expand the CD4,25 T-reg cells that will reroute the immune reaction away from Th2 and toward Th1. This will result in production of IgG's to clear the antigen, rather than excess IgE production.
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Describe RAST testing.
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Allergen in solid phase is exposed to IgE from patient serum. After washing, radio-labeled anti-IgE was added and will attach to IgE if it bound to the allergen. Radioactivity is measured. The allergen is known and is used to predict allergies.
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What tests could be performed on the patient's serum to clarify the reaction?
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RAST for Anti-IgE and ELISA for Anti-IgG.
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What is the only way to treat an immediate, anaphylactic allergic reaction?
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Epinephrine injection.
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How might the use of a specific monoclonal anti-IgE be useful as treatment?
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Binds to IgE's which are specific to certain allergen epitopes.
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