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17 Cards in this Set
- Front
- Back
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Angiopoietin-1
(VEGF) |
Promotes endothelial growth and development
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Stem cell factor
(SCF; c-Kit ligand) |
Promotes hemopoiesis; critical for CFC-B development
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GM-CSF
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Promotes CFC-NM mitosis and differentiation; facilitates granulocyte
activity; stimulates dendritic cell development |
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M-CSF
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Promotes CFC-M mitosis and differentiation; facilitates monocyte activity
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G-CSF
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Promotes CFC-N mitosis and differentiation; facilitates neutrophil activity
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Flt-3 Ligand
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Promotes dendritic cell development
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TNFα
|
Stimulates immature dendritic cells to mature.
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IL-1
|
In conjunction with IL-3 and IL-6, it promotes proliferation of Pluripotential
Hematopoietic Stem Cells (PHSC), CFCGEMM and CFC-Lymphoid. |
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IL-2
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Stimulates activated T- and B-cell mitosis; induces differentiation of NK
cells |
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IL-3
|
In conjunction with IL-1 and IL-6, it promotes proliferation of PHSC, CFCGEMM,
and CFC-Ly as well as all unipotential precursors (except for LyB and LyT) |
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IL-4
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Stimulates B-cell activation and development of mast cells and basophils
Also stimulated dendritic cell development |
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IL-5
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Promotes CFC-Eo mitosis and activates eosinophils; Promotes B cell
growth |
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IL-6
|
In conjunction with IL-1 and IL-3, it promotes proliferation of Pluripotential
Hematopoietic Stem Cells (PHSC), and CFC-Ly; also facilitates B-cell differentiation into plasma cells |
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IL-7
|
Promotes differentiation of CFC-Ly; enhances differentiation of CFC-T/NK
cells and maturation of CFC-B to pro B cells |
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IL-12
|
Stimulates NK cells development and function; enhances CTL function.
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Erythropoietin
|
CFC-E development and differentiation
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Thrombopoietin
|
Proliferation and differentiation of CFU-megakaryocyte and
megakaryoblasts |
