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11 Cards in this Set
- Front
- Back
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What MHC molecule is required for development of a Th1 or Th2 response?
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Antigen-MHC II complex must be recognized by a CD4 Th0 cell.
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What is the result of a Th1 response?
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Macrophage recruitment and activation.
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What is the result of a Th2 response?
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Ab formation.
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What type of infection will require a Th1 response?
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Infectious organisms that require phagocytosis and intracellular killing.
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How is a Th1 response initiated?
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The APC will take up a pathogen by its TLR that requires a TMMI response to be killed. The pathogen uptake results in the release of IL-12, which converts Th0 cells to the Th1 pathway. The antigen is now displayed by a MHC II on the APC, and Th1 cells will recognize this complex and become activated.
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What cytokines does the committed Th1 cell release?
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IL-2 and INF-ϒ.
IL-2 is a growth factor for Th1, CD8, and NK cells. INF-ϒ is a potent macrophage activator and Th2 suppressor. |
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What are the sources of IL-2 during the initiation of the Th1 response?
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Th1, CD8, T-regs, and NK cells.
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What is the end result of a Th1 response?
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TMMI - Macrophages are recruited and activated to kill the pathogen infected host cell, and the classic tetrad of cytokines is released to produce inflammation also.
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What cytokines comprise the classic tetrad?
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IL-1, IL-6, IL-8, and TNF-alpha.
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What is the strategy behind a Th2 response?
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Existence of an extremely small, soluble, extracellular antigen that may require Ab's for macrophages and neutrophils to recognize it.
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What cytokine is absolutely necessary in the Th2 response?
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IL-4, a growth hormone, which is usually released by Th0 cells that end up not being activated by IL-12 to form Th1 cells.
IL-4 and IL-10 will suppress the Th1 pathway. |
