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6 Cards in this Set
- Front
- Back
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Behavioral Effects of LSD
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Visual distortion
outside of body feeling synesthesia (possible reduction in sensory gating) |
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LSD Mechanism of Action
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5-HT 2 receptor agonist - resembles 5-HT (as does psilocybin)
(again, possible reduction in sensory gating) |
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Tests for LSD/psilocybin Mechanism
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Combine hallucinogen with antagonists.
Ketanserin induced 5-HT (2a) blockade inhibits visual changes DA antagonism does not |
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PCP/Ketamine Behavioral Effects
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dissociative anesthetic - lose contact with environment, remain conscious
drug model for positive + negative effects of schizophrenia |
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PCP Mechanism of Action
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Non-competitive NMDA blockade -reduced Glu transmission
potentiation of Amph-induced (maybe stress-induced?) DA release |
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New Mechanism for Schizophrenic Treatment
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Glycine: potentiates NMDA receptors (increase hypofunctioning glutamate system)
D-cycloserine: partial agonist at glycine site |
