Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
8 Cards in this Set
- Front
- Back
|
Hairy Cell Leukemia Clinical
|
Men more affected
splenomegaly pancytopenia - especially monocytopenia confused with MDS often recurrent opportunistic infection, vasculitis, immune dysfunction |
|
|
Hairy Cell Leukemia Morphology
|
Blood lakes in spleen
Abnormal cells have hairy projections on blood smear TRAP stain positive CD20+ stain BM - if see alot then something bad |
|
|
Can you use flow cytometry to diagnose Hairy Cell Leukemia
|
NO due to increased reticular fiber content of tissues
|
|
|
Hairy Cell Leukemia Immunophenotype
|
CD20, CD22, CD11c, CD103, Annexin A1
|
|
|
T/F no cytogenetic abnormality specific to Hairy cell leukemia
|
true
|
|
|
T/F most cases of Hairy Cell Leukemia demonstrate VH genes with somatic hypermutation
|
True - indicates post germinal center stage of maturation
|
|
|
Hairy Cell Leukemia Treatment
|
uniquely sensitive to alpha-interferon or nucleosides - pentostatin or cladribine
Rutiximab |
|
|
Pentostatin, Cladribine
|
nucleoside used in treatment of hairy cell leukemia
|
