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11 Cards in this Set
- Front
- Back
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MOA of barbs
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GABAa receptor
Cl- less Ca less AP... (hyperpolarized) |
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MOA of benzos
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GABAa receptor
ALPHA AND GAMMA SUBUNITS REQUIRED Cl- less Ca less AP... (hyperpolarized) |
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MOA of non-benzos
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Structurally unrelated to benzos but has hypnotic actions
Binds to BZ1 receptors & enhances ability of α GABAa receptors Actions antagonized by flumazenil |
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MOA of buspirone
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Partial agonist at central 5-HT1A receptors
Undergoes extensive 1st pass metabolism (hydroxylation & dealkylations rxns) to form several pharmacologically active aganets. Major metabolite is 1-PP which enters CNS at higher levels than parent drug and has α2 adrenoceptor blocking actions |
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Treatment of Panic Disorders
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SSRI
Alprazolam (xanax) Imipramine MAOI |
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Social Phobia
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SSRI
Clonazepam MAOI Buproprion |
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Generalized Anxiety
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Benzos
Buspirone Venlafaxine |
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Advantage of Benzo
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Low risk of adverse drug interactions due to induction of liver enzymes.
Slow elimination reduces frequency for taking it. High TI Antagonist available |
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Treatment for transient and short term insomnia
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Triazolam (benzo)
Zolpidem ** Eszopiclone ** ** less REM suppression |
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Disadvantages of
Zolpidem Eszopiclone |
Dosage reduction required with hepatic dysfunction, in elderly and with cimetidine.
Respiratory depression at high dose or with CNS depressants (alcohol). |
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What is Ramelteon?
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Melatonin receptor agonist.
approved by FDA for insomnia. not a controlled substance. |
