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18 Cards in this Set
- Front
- Back
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Why types of drugs do we use for Anti-Coagulant Drugs?
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Direct Thrombin Inhibitors Facto Xa Inhibitor Vitamin K Antagonists Anti-Thrombin Activators Thrmobolytic Drugs |
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What are Direct Thrombin Inhibitors?
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Directly Blocks thrombin
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What do Factor Xa Inhibitors Do?
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Stops Factor Xa from making prothrombin complex
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What are Vitamin K Antagonists?
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Naturally Discovered in cows bleeding out eating a clover Warfarin it inhibits the synthesis of Vit K dependatn coagulant factors |
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What are Anti-Thrombin Activators
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They activate antithrombin III which inhibits clotting factors
Heparin |
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What are Thrombolytic Drugs?
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Alteplase
A serine protease that has the property of fibrin enhanced conversion of plasminogen to plasmin |
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Dabigatran
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Direct Thrombin Inhibitor - reversibly binds at the enzymatic catalytic site and anion binding site of thrombin
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Dabigatran Issues
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I: Orthopaedic Surgery CI: Active Bleed, Renal Impairment, Bioprosthetic Heart Valves Can cause Haemorrhage, Anaemia or abnormal liver tests DO NOT use with Heparin, Clopidogrel and Vit K antagonists, Thrombolytic Agents (Basically use as mono therapy. |
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Apixaban
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Faxtor Xa Inhibitor
Stops Xa from making prothrombin complex |
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Apixaban Issues
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I: Venous Thrombosis (knee or hip replacements predom)
CI: Clinically Bleeding, sever hepatic impairment Can Increase risk of bleeding from any organ DO NOT USE with Rifampin or other CYP3A4 inducers e.g carbamezapine as can reduced effectiveness of Apixaban |
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Warfarin
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Vitamin K Antagonist
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Warfarin Issues
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I: Prophylaxis of thrombi embolism, mostly following heart surgery. CI: Recent eye surgery, Spinal Puncture, DVT Can cause Fatal or non- fatal haemorrage from any organ or tissue Can interact with ~ 250 drugs. But be esp careful with St Johns Wort |
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What is Prothrombin time?
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PT test measures the overall activity of the extrinsic coagulation pathway.
Test used to monitor warfarin administration to a patient (for DVT) |
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Heparin
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Activator of antithrombin III
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Heparin Issues
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I: Prophylaxis of thromboembolytic disorder, prevents TE Complications in surgery, Dialysis
CI: Uncontrollable active bleeding, Hypersensitivity to heparin or pork products Can cause Hemmorage DO NOT use with ACEI, K+ Sparing or K+ Supplements, Digitalis, tetracyclines, Nicotine, Antihis, Streptokinase and Urokinase can = Haemorage |
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Altepase
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serine protease that has the property of fibrin enhanced conversion of plasminogen to plasmin
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Altepase Issues
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I: Acute Ischemic, Stroke, MI, Pulmonary embolism
CI: Sig Bleeding disorder, Uncontrolled Hyertension, Major Surgery Can cause bleeding May increase risk of bleeding with coumarin derivatives or other haemostats effectors (Heparin etc) |
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Why is it better to take oral drugs for management of haemostatic conditions?
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Because they last longer.
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