Haemostasis

Front 1

Define Haemostasis

Back 1

The arrest of bleeding

Front 2

What are the 3 broad functions of haemostasis?

Back 2

1. Maintain blood in a fluid state

2. Respond to vessel wall injury - formation of a clot

3.

Front 3

Name 5 components involved in Haemostasis?

Back 3

1) Vascular

2) Primary Haemostasis

3) Secondary Haemostasis (intrinsic or extrinsic)

4) Inhibitors

5) Fibrinolysis

Front 4

Describe primary Haemostasis

Back 4

1) Primary haemostasis intiated by when platelets turn to active dendritic state

2) from binding of collagen bound Von willibrand factor to GPb1 receptor protein on platelet surface

3) stimulates granules within platelets to be released containing agonists e.g ADP, Thrombin and Thromboxane A2

4) these promote aggregation and migration of platelets to plug site where initial primary haemostasic plug is formed

Front 5

What is the purpose of secondary Haemostasis ?

Back 5

Intrinsic and extrinsic coagulation pathways work together to generate cross link fibrin strands to strengthen the haemostatic plug

Front 6

What’s the purpose of fibrinolysis?

Back 6

Enzymatic degradation of the clot by tissue plasminogen activator (t-PA) and urokinase that convert plasminogen to active plasmin which cuts the fibrin mesh at various places

Front 7

Explain three key stages in haemostasis and how vasconstriction, primary haemostasis, secondary haemostasis, inhibitors and fibrinolysis contribute to a vessel wall injury in the body

Back 7

Explain all of it