H. Tumors Of The Lung - Part Ii

Front 1

What is the 2nd least commonly seen of the Bronchogenic carcinomas?

Back 1

Large cell carcinoma, undifferentiated (10-15%)

Front 2

What is the microscopic morphology seen in large cell carcinoma?

Back 2

-Pleiomorphic
-Large undifferentiated cells

Front 3

what is the 5-yr survival rate of large cell carcinoma, undifferentiated?

Back 3

6%

Front 4

What are the 2 subtypes of large cell carcinoma?

Back 4

-Giant cell
-Clear cell

Front 5

Which subtype of large cell carcinoma is worse? Why?

Back 5

Giant cell
<10 month survival

Front 6

How is clear cell carcinoma diagnosed?

Back 6

-Presence of glycogen-rich clear cells
-Exclusion of all other types

Front 7

What is the least frequently seen type of bronchogenic carcinoma of the lung?

Back 7

Adenosquamous carcinoma (1-3%)

Front 8

How is Adenosquamous carcinoma diagnosed?

Back 8

-By seeing evidence of squamous cell carcinoma and adenocarcinoma in the same neoplasm

Front 9

Where are adenosquamous carcinomas typically seen within the lung, and in association with what?

Back 9

-Peripheral
-Associated with scar

Front 10

How does adenosquamous carcinoma behave?

Back 10

Similarly to the normal Adenocarcinoma

Front 11

What do all bronchogenic carcinomas have the potential for?

Back 11

Metastasis

Front 12

What are the 2 routes of metastasis?

Back 12

-Lymphatic
-Hematogenous

Front 13

What is the most COMMON site of metastasis from bronchogenic carcinomas?

Back 13

To the ADRENALS!

Front 14

What are the two most important factors in determining survival and choice of therapy for Bronchogenic carcinomas?

Back 14

-Histologic type
-Tumor stage

Front 15

What classification system is used for staging bronchogenic carcinomas?

Back 15

TNM

Front 16

What is TNM?

Back 16

-Tumor size
-Nodal status
-Metastasis

Front 17

In which bronchogenic carcinoma is the TNM classification the single most important prognostic parameter?

Back 17

Non-small cell carcinoma

Front 18

What is considered Limited disease in a case of SCC?

Back 18

-Only one lung involved, with or without lymph node involvement

Front 19

What is considered Extensive disease in a case of SCC?

Back 19

-Contralateral lung involvement with distant metastasis

Front 20

What weird thing can happen in bronchogenic carcinomas?

Back 20

Paraneoplastic syndrome

Front 21

What are 4 paraneoplastic syndromes associated with SCC?

Back 21

-Cushing's (ACTH)
-Hyponatremia (siADH)
-Carcinoid (serotonin)
-Myasthenic (Eaton-Lambert)

Front 22

What does Eaton-Lambert cause?

Back 22

Muscle weakness

Front 23

What paraneoplastic syndrome is associated with squamous cell carcinoma?

Back 23

Hypercalcemia (PTH)

Front 24

What % of paraneoplastic syndromes cause clinical symptoms?

Back 24

1-10%

Front 25

What is the overall outlook for patients with bronchogenic carcinoma? What is the 5-yr survival rate?

Back 25

Poor outlook for all types of bronchogenic carcinoma;
5-yr survival is 9%

Front 26

What is the survival rate for mixed, SCC and AdenoCa?

Back 26

Better, 10%

Front 27

What is the 5-yr survival rate for SCC alone?

Back 27

3%

Front 28

What % of all lung tumors are Carcinoid tumors?

Back 28

1-5%

Front 29

What age are most patients that present with Carcinoid tumors?
What sex?

Back 29

Age is <40

Males = Females

Front 30

What % of carcinoid cancer patients are nonsmokers?

Back 30

20-40%

Front 31

How severe are the Carcinoid lung tumors? What are 2 types?

Back 31

Low-grade
-Typical
-Atypical

Front 32

What do carcinoid lung tumors look like grossly?

Back 32

-Well circumscribed
-Polyploid
-Jut into the bronchial lumen

Front 33

What is the microscopic appearance of Carcinoid tumors?
-Cells form
-Chromatin appearance

Back 33

Cells form nests/cords/masses
Salt/pepper chromatin
Uniform cells have round nuclei

Front 34

What is RARELy seen in carcinoid tumors?

Back 34

Metastasis

Front 35

What is the 5 and 10-yr survival rate for Carcinoid tumors?

Back 35

87%!!