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14 Cards in this Set
- Front
- Back
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How many misc anti-neoplastic agents are there to know?
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only 2!
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What are the 2 misc anti-neoplastic drugs?
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-Cisplatin
-Procarbazine |
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What IS Cisplatin (important in its mechanism)?
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A platinum coordination complex
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How does Cisplatin work?
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Hydrolysis of the platinum coordination complex yields activated species that cause DNA crosslinks
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What is the antitumor spectrum of Cisplatin?
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WIDE spectrum!
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What are 4 side effects of Cisplatin in addition to the normal BADs?
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NOPE
-Nephrotoxicity -Ototoxicity -Peripheral neuropathy -Electrolyte disturbances |
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What % of patients on Cisplatin get
-Ototoxicity -Electrolyte disturbances |
Ototoxic - 30%
Electrolyte disturb - 60% |
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Just as a reminder what antinausea drug is good for chemo-induced nausea?
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Ondansetron - cholinergic antagonist
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What is the best way to prevent nephrotoxicity from Cisplatin?
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HYDRATE and DIURESE to flush it on through asap before renal dmg occurs
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What is the other misc antineoplastic drug?
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Procarbazine
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What is Procarbazine?
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A nonclassical alkylating agent
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How does Procarbazine work?
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-Activated by liver P450s to a methylating agent that causes chromosomal damage
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What is the main cancer indication of Procarbazine?
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Hodgkin's lymphoma
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Side effects of Procarbazine?
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The typicals - bad
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