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10 Cards in this Set
- Front
- Back
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a) What percentage of gynecologic malignancies are vaginal cancers?
b) Cancer found in the vagina is more likely to be primary or metastatic? c) At diagnosis if cancer of the vagina extends to the cervix or vulva, is it still diagnosed as vaginal cancer? |
a) 1-2%.
b) Metastatic c) No. |
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List cancers that extend or metastasize to the vagina.
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Endometrium
Cervix Vulva Ovary Breast Rectum Kidney GTN |
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List histologic types of vaginal cancer, and which is most common?
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SCC (85%)
Clear cell adenocarcinoma (**in utero DES exposure) Adenocarcinoma Sarcoma Melanoma Undifferentiated Small cell Lymphoma Carcinoid |
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Describe the blood supply to the vagina.
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Vaginal a.
Descending branch of uterine/cervical a. Middle rectal a. Internal pudendal a. |
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Describe lymphatic drainage from the vagina.
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Proximal 2/3: same as uterus - iliac nodes
Distal 1/3: vulvar lymphatics to inguinal nodes Posterior vagina may drain to presacral/perirectal nodes |
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Describe innervation of the vagina
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pelvic (inferior hypogastric) plexus
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What is the primary histologic cell type/structure of the vaginal epithelium?
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Stratified squamous non-keratinized epithelium
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List risk factors for vaginal cancer
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Age
HPV (high-risk subtypes) Five or more lifetime sexual partners Early coitarche Smoking Previous gynecologic malignancy (e.g. cervix, vulva - ? from HPV or from treatment/RT?) |
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If biopsying a lesion in the vagina suspicious for VAIN/malignancy, what else must be done?
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Pap test / colposcopy.
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What is the most common site for vaginal cancer to occur?
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Posterior upper 1/3
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