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16 Cards in this Set

  • Front
  • Back
PUNLMP's often progresses to worse lesions with recurrences?
- when they do recur, it is typically as a similar lesion
- rarely are they associated with progression
- follow-up is indicated however
squamous papillomas differ from condyloma accuminatum by ___
- a lack of koilocyte atypia and no demonstrable HPV 6/11
Deep muscle invasion can be determined on an adequate bladder biopsy?
NO! Adipose tissue can be present in the muscularis propria and lamina propria too! Can only determine this on a partial or complete cystectomy specimen.

- However, do mention the presence or absence of muscularis propria for all bladder biopsies
Carcinoma in situ in the bladder must be full-thickness to qualify for this diagnosis?
NO! In the bladder, any number of cytologically malignant cells in the non-papillary urothelium is cis!
urothelial atypia/dysplasia is used when _
- insufficient cytologic atypia to justify a dx of cis
- used when there is aytpia that is favored to be neoplastic, but just cannot quite make the diagnosis
The giant cells in urothelial carcinoma with osteoclastic giant cells are neoplastic??
- believed to be a reaction to the tumor
- no affect on prognosis
urothelial carcioma, clear cell variant is distinguished from clear cell adenocarcinoma morphologically by __
- presence of typically papillary or in situ lesions
- lack of the tubular, microcystic, and hobnail features
urothelial carcinoma with ectopic placental glycoprotein production (usually beta-hCG): the hCG immunopositivity differs from that seen in choriocarcinoma by ___
- immunoreactivity in urothelial caricnoma is NOT confined to the syncytiotrophoblasti-like giant cells
nested variant of urothelial carcinoma can mimic __
- von Brunn nest!!
- however, urothelial carcinioma shows more variation in nest size and contour, and have MILD nuclear atypia
- at the deeper aspects there is typically greater anaplasia!
Adenocarcinoma of the bladder is the tumor type common in ___
bladder extrophy
The common sarcoma of the bladder in children and adults
- children: rhabdomyosarcoma (sarcoma botryoides) in the trigone area

- adults: leiomysarcoma
squamous metaplasia in the trigone of the bladder, similar histologically to the lining of the ___ is common in reproductive age women
- nonkeratinized vaginal mucosa; NOT a significant risk factor for caricnoma
- contrast: leukoplaskia (keratinizing squamous metaplasia IS a significant risk factor for carcinoma; most SCC of the bladder arise from areas of keratinizing squamous metaplasia
Papillary-polypoid cystitis resembles cystopically a __
- papillary neoplasm
- not neoplastic; it's an exophytic lesion due to inflammation and edema
primarmy amyloidosis of the bladder extensively involves the vessel walls??
NO! Not in primary amyloidosis
glandular metplasia in the bladder is a risk factor for urothelial carcinoma??
- EXTENSIVE glandular metaplasia is a risk factor for ADENOcarcinoma!
most bladder cysts are of __ origin, and occur in the __
- urachal origin
- anterior wall or dome