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16 Cards in this Set

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  • Back
PUNLMP's often progresses to worse lesions with recurrences?
NO!!
- when they do recur, it is typically as a similar lesion
- rarely are they associated with progression
- follow-up is indicated however
squamous papillomas differ from condyloma accuminatum by ___
- a lack of koilocyte atypia and no demonstrable HPV 6/11
Deep muscle invasion can be determined on an adequate bladder biopsy?
NO! Adipose tissue can be present in the muscularis propria and lamina propria too! Can only determine this on a partial or complete cystectomy specimen.

- However, do mention the presence or absence of muscularis propria for all bladder biopsies
Carcinoma in situ in the bladder must be full-thickness to qualify for this diagnosis?
NO! In the bladder, any number of cytologically malignant cells in the non-papillary urothelium is cis!
urothelial atypia/dysplasia is used when _
- insufficient cytologic atypia to justify a dx of cis
- used when there is aytpia that is favored to be neoplastic, but just cannot quite make the diagnosis
The giant cells in urothelial carcinoma with osteoclastic giant cells are neoplastic??
No!
- believed to be a reaction to the tumor
- no affect on prognosis
urothelial carcioma, clear cell variant is distinguished from clear cell adenocarcinoma morphologically by __
- presence of typically papillary or in situ lesions
- lack of the tubular, microcystic, and hobnail features
urothelial carcinoma with ectopic placental glycoprotein production (usually beta-hCG): the hCG immunopositivity differs from that seen in choriocarcinoma by ___
- immunoreactivity in urothelial caricnoma is NOT confined to the syncytiotrophoblasti-like giant cells
nested variant of urothelial carcinoma can mimic __
- von Brunn nest!!
- however, urothelial carcinioma shows more variation in nest size and contour, and have MILD nuclear atypia
- at the deeper aspects there is typically greater anaplasia!
Adenocarcinoma of the bladder is the tumor type common in ___
bladder extrophy
The common sarcoma of the bladder in children and adults
- children: rhabdomyosarcoma (sarcoma botryoides) in the trigone area

- adults: leiomysarcoma
squamous metaplasia in the trigone of the bladder, similar histologically to the lining of the ___ is common in reproductive age women
- nonkeratinized vaginal mucosa; NOT a significant risk factor for caricnoma
- contrast: leukoplaskia (keratinizing squamous metaplasia IS a significant risk factor for carcinoma; most SCC of the bladder arise from areas of keratinizing squamous metaplasia
Papillary-polypoid cystitis resembles cystopically a __
- papillary neoplasm
- not neoplastic; it's an exophytic lesion due to inflammation and edema
primarmy amyloidosis of the bladder extensively involves the vessel walls??
NO! Not in primary amyloidosis
glandular metplasia in the bladder is a risk factor for urothelial carcinoma??
NO!
- EXTENSIVE glandular metaplasia is a risk factor for ADENOcarcinoma!
most bladder cysts are of __ origin, and occur in the __
- urachal origin
- anterior wall or dome