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16 Cards in this Set
- Front
- Back
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PUNLMP's often progresses to worse lesions with recurrences?
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NO!!
- when they do recur, it is typically as a similar lesion - rarely are they associated with progression - follow-up is indicated however |
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squamous papillomas differ from condyloma accuminatum by ___
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- a lack of koilocyte atypia and no demonstrable HPV 6/11
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Deep muscle invasion can be determined on an adequate bladder biopsy?
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NO! Adipose tissue can be present in the muscularis propria and lamina propria too! Can only determine this on a partial or complete cystectomy specimen.
- However, do mention the presence or absence of muscularis propria for all bladder biopsies |
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Carcinoma in situ in the bladder must be full-thickness to qualify for this diagnosis?
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NO! In the bladder, any number of cytologically malignant cells in the non-papillary urothelium is cis!
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urothelial atypia/dysplasia is used when _
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- insufficient cytologic atypia to justify a dx of cis
- used when there is aytpia that is favored to be neoplastic, but just cannot quite make the diagnosis |
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The giant cells in urothelial carcinoma with osteoclastic giant cells are neoplastic??
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No!
- believed to be a reaction to the tumor - no affect on prognosis |
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urothelial carcioma, clear cell variant is distinguished from clear cell adenocarcinoma morphologically by __
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- presence of typically papillary or in situ lesions
- lack of the tubular, microcystic, and hobnail features |
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urothelial carcinoma with ectopic placental glycoprotein production (usually beta-hCG): the hCG immunopositivity differs from that seen in choriocarcinoma by ___
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- immunoreactivity in urothelial caricnoma is NOT confined to the syncytiotrophoblasti-like giant cells
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nested variant of urothelial carcinoma can mimic __
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- von Brunn nest!!
- however, urothelial carcinioma shows more variation in nest size and contour, and have MILD nuclear atypia - at the deeper aspects there is typically greater anaplasia! |
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Adenocarcinoma of the bladder is the tumor type common in ___
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bladder extrophy
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The common sarcoma of the bladder in children and adults
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- children: rhabdomyosarcoma (sarcoma botryoides) in the trigone area
- adults: leiomysarcoma |
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squamous metaplasia in the trigone of the bladder, similar histologically to the lining of the ___ is common in reproductive age women
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- nonkeratinized vaginal mucosa; NOT a significant risk factor for caricnoma
- contrast: leukoplaskia (keratinizing squamous metaplasia IS a significant risk factor for carcinoma; most SCC of the bladder arise from areas of keratinizing squamous metaplasia |
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Papillary-polypoid cystitis resembles cystopically a __
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- papillary neoplasm
- not neoplastic; it's an exophytic lesion due to inflammation and edema |
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primarmy amyloidosis of the bladder extensively involves the vessel walls??
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NO! Not in primary amyloidosis
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glandular metplasia in the bladder is a risk factor for urothelial carcinoma??
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NO!
- EXTENSIVE glandular metaplasia is a risk factor for ADENOcarcinoma! |
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most bladder cysts are of __ origin, and occur in the __
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- urachal origin
- anterior wall or dome |
