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16 Cards in this Set
- Front
- Back
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The ease at which ions can pass through the open channels? |
Channel Permeability p. 72 |
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The direct measure of how rapidly ions move through a channel |
Channel Current p71 |
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Permeability + ions = ______________. |
Conductance p72 |
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The current of a channel is dependent on what two factors? |
Driving Force and Channel Conduction p71 |
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What is the name of the potential that balance the potassium concentration gradient? |
The potassium equilibrium concentration p73 |
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The duration of an ion channel's open and closed states can be defined as its ___? |
Kinetic behavior p70 |
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Consider a cell at rest, a voltage of +20mV misapplied across the membrane. What ion (Na+ or K+) will move, and will it move into or out of the cell? |
-K+ will move out of the cell. It will try to bring the membrane potential back to it's equilibrium potential due to it's electrochemical gradient p 73 |
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If we increase the concentration of K+ ions inside of a cell, will that cell's conductance increase or decrease? |
Increase p72 |
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The output from a patch clamp amplifier is proportional to what? |
Current across the patch (Fig. 4.6, p71) |
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What does the channel conductance measure? |
the ability of the channel to pass current p71 |
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What is the name of the unit of conductance?
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the siemens (s) p71 |
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The conductance of a channel depends upon channel permeability and _______. |
The concentration of ions in the region of the channel. p72 |
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If the size of a current increases and no other factors change, the voltage will _____. |
Increase p71 |
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T/F: When reading oath clan recording, downward deflections always indicate current flowing into the cell. |
FALSE: read ins can be taken from an inside out patch, which would show downward defections as flowing out of the cell (Fig 4.5) |
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If no potential is applied to a spontaneously active potassium channel in a patch, how many channel currents would be soon on the patch clamp recording? |
No potential -> no net flux through channel-> no channels current visible (Fig 4.6) |
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Current through a potassium channel depends on the __________ across the membrane and the _______ for the potassium. |
Electrical potential and concentration gradient (Fig 4.7) |
