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22 Cards in this Set
- Front
- Back
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Bacillus is what?
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ubiquitous in soil
spore forming aerobic/facultive usually catalase + often beta hemolytic and motile(not B. anthrax) |
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Bascillus cereus toxins
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stable emetic enterotoxin
heat labile diarrhea enterotoxin similar to cholera toxin(secretory) |
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Bacillus cereus clinical issues
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ocular infection post surgery
prosthetic/catheter sepsis meningitis |
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B. anrthacis spread route?
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to lymph nodes then to bloodstream
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B. anthracis virulence factors?
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poly D-glutamic acid capsule
3 part exotoxin |
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3 exotoxins?
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PA-protective antigen that binds to cell to let in EF/LF
EF-edema factor activating adenyl cyclase to cause edema at site of injury LF-lethal factor, disrupts cell functions and triggers TNF-a, IL-1 |
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anthrax vaccine?
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nonencapsulated form, required yearly, painful, military only
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Listeria monocytogenes
shape, description, natural resistances |
cat+
CAMP+ bile+(esculine) beta hemolytic bacillic/coccobacilli can life at 4 deg C naturally resistant to cephalosporins |
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Listeria pathogenisis
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can grow inside macrophage or epithelial cells
asymptomatic carrier reserver hemolysin(lysteriolysin) |
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Erisipelothrix rhusopathe
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bacillius, primarily only in animals, can cause bacterimeia, usually erysipeloid(non-suppurative) and skin lesion
non-spore forming facultive anaerobe rod |
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mycolic actinomyces?
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Mycobacterium
Corynbacterium |
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Corynbact specific
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curved pleomorphic rods
facultive anaerobe grow on sheep blood oxidase+ cell walls with arabinose, galactose, meso-DAP, and short mycolic acids |
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C. diptheria pathogenesis
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droplet spread
Phospholipase D increases vasc permability phage coded exotoxin, attacks EF-2, kills respiratory mucous membranes toxin spread to heart/adrenals/cns grown with cystein/tellurite |
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Other corynbac pathogens?
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jeikium- infection(oppertunist of marrow transplant pts)
multidrug resistant except vancomy urealyticum--UTI's and stones |
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Nocardia locale
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ubiquitous in enviroment--inhalation/cutaneous innoculation
HIV oppertunist |
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nocardia virulent factors
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superoxide dismutase+
cord factor to prevent phagolysosome fusion and intracellular killing |
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nocardia pathogenesis
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pneumonia, meningitis/brain abcesses, lung abcesses, cellulitus, mycetoma
characterized by fibrosis/necrosis/pus tracts |
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nocardia lab info
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slow growing, ~7days in 5% CO2
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Rhodococcus equi
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weakly acid fast
reverts to coccus aids/transplant oppertunist facultive intracellular(phage), granuloma formation/abcess |
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Tropheryma whippli
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actinomyce, causes whipples malabsorbtion of small bowl, non-growable
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Most common nocardia in us
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asteroids
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4 forms of nocardia
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pulmonary
extra pumonary cutaneous mycetomas |
