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13 Cards in this Set
- Front
- Back
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Corynebacterium diphtheria
Morphology/Biochem: (1) shape (2) motility (3) see with methylene blue? (4) tellurite reduction? (5) hemolysis |
(1) club-shaped (Chinese letters)
(2) nonmotile (3) metachromatic granules (4) tellurite-pos (5) hemolysis-neg |
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Corynebacterium diphtheria
Exotoxin: (1) encoded by...? (2) negative reg'd by...? (3) role of A subunit (4) role of B subunit (5) how inhib protein synth? |
(1) lysogenic bacteriophage
(2) iron (3) inhibit protein synth (4) binding activity (5) ADP-ribosylation of EF2 |
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Corynebacterium diphtheria
Diseases: (1) resp (give char's) (2) cardiac (3) neurologic (4) cutaneous |
(1) resp: pseudomemb, sore throat, fever, neck edema
(2) cardiac: arrhythmia, myocarditic within 2-3 wks (3) motor neurons (4) impetigo-like -> brownish gray memb; tropical areas, homeless |
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Corynebacterium diphtheria
Treatment: (1) triad of treatment (2) available vaccines |
(1) antitoxin, antibiotic, vaccination
(2) DTaP every 10 years |
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Listeria monocytogenes
Morphology/Biochem: (1) motility (2) hemolysis (3) catalase (4) telluride (5) grow in fridge? |
(1) yes motile
(2) weakly hemolytic-pos (3) catalase-pos (4) tellurite-pos (5) YES, can grow at 4 C |
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Listeria monocytogenes
Pathogenesis: (1) Transmission (2) Do antibodies help? (3) Diseases in healthy pts (4) Diseases in immunocomp'd pts (5) Treatment |
(1) bad food, direct cutaneous
(2) no, need activated macrophages (3) febrile gastroenteritis maternal listeriosis (flu-like, infects fetus) perinatal listeriosis (sepsis, meningitis) (4) sepsis, meningitis (5) antimicrobials |
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Bacillus anthracis
Morphology/Biochem: (1) motility (2) sporulation (3) capsule (4) appearance (5) hemolysis (6) can grow on what sources? |
(1) non-motile
(2) yes spores (3) encapsulated (4) boxcars (5) hemolytic-neg (6) simple carbon, nitrogen |
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Bacillus anthracis
Diseases: (1) cutaneous (2) intestinal (3) pulmonary |
(1) papule -> ulcer -> eschar
(2) abd pain, bloody diarrhea, vomit (3) Woolsorter's diseases: flu -> pneumonia, sepsis |
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Bacillus anthracis
Virulence Factors: (1) what's unique about capsule? (2) tripartite toxin |
(1) anti-phagocytic polypeptide
(2) Lethal Factor (LF), Edema Factor (EF), Protective Antigen (PA) |
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Bacillus anthracis
Treatment: (1) drugs (2) vaccines (3) PA inhibitors |
(1) ciprofloxacin, doxycycline (susceptible to penicillin, but prbly too late)
(2) anthrax vaccine absorbed (AVA), recombo PA, atten live (3) antibodies, small molc inhib's |
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Bacillus cereus
Morphology/Biochem: (1) motility (2) sporulation (3) capsule (4) hemolysis (5) resistance |
(1) yes motile
(2) yes spores (3) no capsule (4) hemolytic (5) penicillin-resistant |
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Bacillus cereus
Diseases: (1) Gastroenteritis--sx (2) Cellulitis--who gets it? (3) Endophthalmitis--who gets it? |
(1) vomit -> diarrhea
(2) leukemics, very immunocomp'd (3) eye trauma, IV drug users |
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REST STOP
Morph/Biochem Summary |
(1) Gram = positive
(2) Motile = Listeria, B. cereus (3) Hemolytic = Listeria (weak), B. cereus (4) Capsule = B. anthracis (5) Tellurite = diphtheria, Listeria (6) Penicillin = diphtheria (7) Spores = B. aereus, B. anthracis |
