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13 Cards in this Set

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Corynebacterium diphtheria

Morphology/Biochem:
(1) shape
(2) motility
(3) see with methylene blue?
(4) tellurite reduction?
(5) hemolysis
(1) club-shaped (Chinese letters)
(2) nonmotile
(3) metachromatic granules
(4) tellurite-pos
(5) hemolysis-neg
Corynebacterium diphtheria

Exotoxin:
(1) encoded by...?
(2) negative reg'd by...?
(3) role of A subunit
(4) role of B subunit
(5) how inhib protein synth?
(1) lysogenic bacteriophage
(2) iron
(3) inhibit protein synth
(4) binding activity
(5) ADP-ribosylation of EF2
Corynebacterium diphtheria

Diseases:
(1) resp (give char's)
(2) cardiac
(3) neurologic
(4) cutaneous
(1) resp: pseudomemb, sore throat, fever, neck edema
(2) cardiac: arrhythmia, myocarditic within 2-3 wks
(3) motor neurons
(4) impetigo-like -> brownish gray memb; tropical areas, homeless
Corynebacterium diphtheria

Treatment:
(1) triad of treatment
(2) available vaccines
(1) antitoxin, antibiotic, vaccination
(2) DTaP every 10 years
Listeria monocytogenes

Morphology/Biochem:
(1) motility
(2) hemolysis
(3) catalase
(4) telluride
(5) grow in fridge?
(1) yes motile
(2) weakly hemolytic-pos
(3) catalase-pos
(4) tellurite-pos
(5) YES, can grow at 4 C
Listeria monocytogenes

Pathogenesis:
(1) Transmission
(2) Do antibodies help?
(3) Diseases in healthy pts
(4) Diseases in immunocomp'd pts
(5) Treatment
(1) bad food, direct cutaneous
(2) no, need activated macrophages
(3) febrile gastroenteritis
maternal listeriosis (flu-like, infects fetus)
perinatal listeriosis (sepsis, meningitis)
(4) sepsis, meningitis
(5) antimicrobials
Bacillus anthracis

Morphology/Biochem:
(1) motility
(2) sporulation
(3) capsule
(4) appearance
(5) hemolysis
(6) can grow on what sources?
(1) non-motile
(2) yes spores
(3) encapsulated
(4) boxcars
(5) hemolytic-neg
(6) simple carbon, nitrogen
Bacillus anthracis

Diseases:
(1) cutaneous
(2) intestinal
(3) pulmonary
(1) papule -> ulcer -> eschar
(2) abd pain, bloody diarrhea, vomit
(3) Woolsorter's diseases: flu -> pneumonia, sepsis
Bacillus anthracis

Virulence Factors:
(1) what's unique about capsule?
(2) tripartite toxin
(1) anti-phagocytic polypeptide
(2) Lethal Factor (LF),
Edema Factor (EF),
Protective Antigen (PA)
Bacillus anthracis

Treatment:
(1) drugs
(2) vaccines
(3) PA inhibitors
(1) ciprofloxacin, doxycycline (susceptible to penicillin, but prbly too late)
(2) anthrax vaccine absorbed (AVA), recombo PA, atten live
(3) antibodies, small molc inhib's
Bacillus cereus

Morphology/Biochem:
(1) motility
(2) sporulation
(3) capsule
(4) hemolysis
(5) resistance
(1) yes motile
(2) yes spores
(3) no capsule
(4) hemolytic
(5) penicillin-resistant
Bacillus cereus

Diseases:
(1) Gastroenteritis--sx
(2) Cellulitis--who gets it?
(3) Endophthalmitis--who gets it?
(1) vomit -> diarrhea
(2) leukemics, very immunocomp'd
(3) eye trauma, IV drug users
REST STOP
Morph/Biochem Summary
(1) Gram = positive
(2) Motile = Listeria, B. cereus
(3) Hemolytic = Listeria (weak), B. cereus
(4) Capsule = B. anthracis
(5) Tellurite = diphtheria, Listeria
(6) Penicillin = diphtheria
(7) Spores = B. aereus, B. anthracis