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65 Cards in this Set
- Front
- Back
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What are the features if the Gram Negative Bacillus psuedomonas?
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Gram Negative Rod
Catalase Positive Aerobic |
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What are the features of Psuedomonas Aeruginosa?
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Oxidase Positive
Gram Negative RODS NON-fermenting PYOcyanin pigment: Blue-greem Slime layer: Non Lactose fermenter on EMB or MacKonkey |
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What type of order does psuedomonas give off?
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Fruity and Grape like ordors
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What does PSuedomonas look like on burn infections?
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blue-green pus, fruity
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Whom does Psuedomonas cause infections in
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Typical Pneumonia, CGD, or CF
UTi-caths |
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What is the Path of Psuedomonas?
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Endotoxin: Shock and Septicimia
Psuedomonas EXotoxin: A: ADP ribosylates EF-2: Stops protein syntheisis LIVER IS THE PRIME TAGET Capsule/slyme layer: Forms Pulmonary micorcolonies |
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What Dz's does Psuedomonas cause?
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Hot tub foliciulitis
eye ulcers BURN: Cellulitis--> Blue GREEN pus--> Septicemia CGD: Pneumonia (Psuedomonas is CAT +) SEPTICEMIA: ERYTHEMA Gangrenosum: |
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What is the Tx: For Psuedomomnas?
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antipsuedomonal penecillin and an aminoglycoside
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What are the Features of Legionella?
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Weakly GRAM NEGATIVE
PLEOMorphic Rods requiring cysteine and iron: Water organisms |
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What are the DISTINGUISHING features of LEgionella?
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STain POOR w. gram stain: Gram NEgative
Fastidious: Requires IRON and Cysteine IT IS FACULATIVE AND intracellular |
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What are predisposing factors to legionella infection?
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Smoker over 55: WITH HIGH alcohol intake.
Immunosuppressed pt.s Faculative and Intracellular |
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Legionella clinical Vignette
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Elderly Man smokerL Heavy drinker or immunosuppressed.
ATYPICAL PNEUMOnia Exposure to aC or aerosols of water, |
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What are the dz.'s caused by legionella?
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Legionairre's Dz: Pneumonia, menta confusion, diarrhea
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How is Legionella diag?
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DFA
or Dieterle SILVER stain 4X increase in Antibody |
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What is the tx for LEgionairre;s
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Flouroquinolone, arithromyxin or erythromycin with rifampin for immunocmp.
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What are the features of Francisella?
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Gram NEg.
Small ROD Faculatitive INTRACellular |
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CLinical Of Francisella
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TIck bit: Uroglandular dz: FEver and ulcer @ bite site: Usually a hunter of rabbits or deer in ARKANSAS or MISSOuri
Dz: TULEREMIA |
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How is Fracisella Tx?
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Streptomycin
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What r the genus features of Bordetella?
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GrAM negative Small rodds
STRICT AEROBES |
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Clinical Vignette of Bordetella
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Bordetella Pertussis: Unvaccinated child, COUGH with a inspiratory whoop
Aerobic Resevoir HUMAN |
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what is the path of Bordetella Pertusis?
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B. Pertusis is a mucosal surface pathogen
attachment: nasophryngeal ciliated epithelial cells Pertusis toxin: Aids in attatchment Adenylate cyclase toxin: Impairs leukocyte chemotaxis; Inhbits phagocytosis and causes local edema. Tracheal toxin: Kills cilia Pertusis Toxin: ADP ribosylation of Gi |
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Disease of Bordtella Pertusis
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Whooping cough (pertusis) 3 stages
1.) 2 week: Catarrhal stage rhinorrhea, malaise, fever, sneeze CONTagious 2.) 4 weeks: PARoxysmal: Repetitive coughs with whoops, vomiting, eye hemmorages: Organism disappears 3.) >3 weeks: CONVElescence: Pneumonoa, seizures, epilepsu. |
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what is Bordetella pertusis immunity?
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Vaccine: 5-10yrs
Vaccinated humans >10 yrs. can serve as a resevior |
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What is the Pertusis Vaccine composed of?
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Pertusis toxoid
Filamentous hemagluttinin Pertactin (OMP) |
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How is Bordetella diagnosed?
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Regan-Lowe or Bordet-Gengou media
DFA of nasophyngeal smear |
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what is the treatment of Bordetella?
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ERYTHOMYCIN or macrolides
DTap: Wanes @ 5-7 yrs Immunity is IgA and babies r born with little immunity from mother. |
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Brucella: Features
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Gram NEg: Zoonosis
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What is the Clinical vignette for Brucella?
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Gram Neg. Aerobic rod,
Faculatative and Intracellular Pt. w/ acute septicemia, Exposure to unpasturized DIARY: States: Ca, Texas or Mexico |
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Brucella Path and Tx
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Endotoxin:
Forms Granulomas Fever is usually in the evening TX: Adults: Rifampin and DOxy for 6 weeks Children: RIFAMPIn and Cotrimazole. DO NOT CULTURE AB agianst brucella --> + |
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Campylobacter Charachterisitics
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GRAM NEGATIVE: CURVED RODS with Polar flagella "gull wings"
Oxidase POSTITVE |
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Clinical Vignette CAMPYLOBACTER JEJUNI
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PT. w/ INFLAMMAtory DIarrhea
Gram Neg: Curved Rod Microaerophilic OXidase POSTIVE GRows @ 42 degrees |
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What is the Pathogenesis of CAmpylobacter Jejuni?
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LOW infx dose(500)
Invades colon mucosa pus in stools |
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Diseases caused bY C. Jejuni?
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Gasteroentritis: 10 or more BLOODy stools a day
Self linitkng 3-5 days Complications: Guillane-Barre syndrome: SEROTYPE 0:19 |
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How is C. Jejuni culturedand Tx
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Camplyuobacter or skirrow agar
Treatr: Supportive Erythromycin or fluouroquinolones PENecillin Resistant |
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Heliobacter Features
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Gram NEgative SPIRAL bacilli with flagella
Microaerophilic: 37 degree growth, OXIDASE POSITIVE |
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Heliobacter Pyelori what is the distinguishing feature
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UREASE POSITIVE
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What is the PAth of H. Pyelori
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-MOTILE
-Urease Positive -Mucinase: Penetrates mucous layer. -Invasive into stomach lining 2 Types I and II TYPE I: VACulating cytoxin |
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What is the H. Pyelori Breaht test
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C13 uread swallowed--. amonnia + C13-C02 produced.
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What is the Tx for H. Pyelori
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OMPIRAZOLE + Amoxicillin+ Clarithromycin
Tx: 10-14 Days |
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Enterobacterie: Features
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Gram -
Faculatative ANaerobes CYCOCHROME C. NEGATIVE Reduces NITRATEs--> NITRITES Cat + |
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What is the pathogenesis of Enterobactericae
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Has ENDOTOXIN
Ferments LActose Has O, antigen, H, K, Vi |
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What 2 organisms ferment lactose?
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Kelbsiella and Escheria
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What are NOn-Lactose Fermenters
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Non-Motile Non H2S: Shigella and yersinia
MOTILE andd H2S: SALmonella and PROTEUS |
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Escheria:FEatures
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Gram Negative rods
Enterobacteracie FERMENT LACTOSE |
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What are the distinguising features of Escheria Coli?
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GRAM NEG. ROD
Faculatative ANaerobe Oxidase Negative E-Coli ferments Lactose; iridescent green on MEB (can be from Bovine fecal cont) |
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What do you screen E-coli with?
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Sorbitol - Mackonkety Agar
BUT EHEC does NOT ferment SOrbitol. |
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What is the pathogenesis of E-COli in a UTI?
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Path: Motility AId
Adherence to urpepithelium important: Pyelonephritis-associated-Pilli Tx- Sulfonamides |
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What is the pathogenesis of E-coli in neonatal septicemia and Meningitis?
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2nd MCC after S. pneumo
Capsule Most strains have K1 serotypoe Endotoxin trigger shock and inflammation. @ BBB and facilitates invasion |
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What bugs increase CAMP
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Cholera
Anthrax E.Coli Pertussis |
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What are the 2 toxins of ETEC and how do they work
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1.) LT: Labile toxin: Stimulated ADENYLATE cyclase
ADP ribosylation of Gs: Increase camp--> CL- ions: watery diaarhea 2.) ST: Stabel toxin: Guanylate cylas |
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What dz does EPEC cause
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Infantile watery diaarhea
EPEC: Watery diarrhea |
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What does EIEC cause
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Invades LARGE Bowel BLOODY diaarhea
Tx: Flouroquinolones |
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What does EHEC cause
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It has Verotoxin
0157: H7 HUS VEROTOXIN STOP 60s |
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Enteroaggrative E-coli
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BRICK LIKE
FIBRIAE PErsistant diaahea |
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What does SHigella look like
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Non MOTILE GRAM neg bacilli: NO LACTOSE, NO H2s
Pt. has shallow ulcers, bloody diarrhea and fever. |
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How does Klebsiella Present?
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Elderly pt. w/ typical Current Jelly Pneumonia
GRAM NEG OXIDASE NEG, ENcaspulated lactose fermenter |
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SOme Killer have Pretty Nice Capsules
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Encapsulated bacteria
S. S. Pneuml K: Klebsiella H. H. Infleunzae TYPE B Psuedomonas N: Neisseria MENIngitis C: Cryptococcus Neofromasn |
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What is the Tx for Klebsiella
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3rd gen Cephalo
or Floruoqquinolone |
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what r the clinical vigneet for Salmonella
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Fever and AB pain
Endemic area travel Gram NEg, encapsulated non lactose Produces H2S WIDAL TEST ROse spots on abdomen |
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What does Salmonella enteritica look like clinically
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Sickle cell" OSteomyleitis
Gram Neg bacillus Motile PRODUCES h2s 6-48 hrs nausea vmit ab. pain headach chikcen or pet turtles |
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How does Yersina Pestis present
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Gram Neg. rod
PT with HIGH FEVER BUBOUS and conjunctivitis Exposure to SMALL rodents in the SOuth west TX: AG |
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How does yersinia entercoloitis present?
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Inflammatory diarrhea, and Psudeoappendecitis
NON H2S, GRam NEg bacilli Non-Lactose fermenter |
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What is the Weil-Felix test
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Antigens of OX strains of Protues vulgaris Cross-react with ricksettial organism
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What does proteus Presnt as
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Swarmimg motility
Gram neg UTI or speticmeia Staghorn calculi Tx: FQ |
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What disease has a rash that starts on ankles and wrists and spreads centripetallyu? And what is the tX?
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Ricksettie Ricksetti (dermancantor tick)
ROCKY MNT. SPotted Fever TX; DOXYcylcine |
