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33 Cards in this Set
- Front
- Back
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What disease is Stomatoccus associated with?
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Endocarditis
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What makes Staphylococcus Oxidase -?
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Lack of Cytochrome C
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Which species of Staphylococcus is used industrially?
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S. xylosus
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What causes scalded skin syndrome?
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Exfoliatin
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Which pathogenic factors are genetically encoded in S. aureus?
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Hemolysins, proteases, Protein A, clumping factor, capsule production, nucleases.
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Which pathogenic factors in S. aureus are obtained through Lysogenic Conversion?
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staphylokinase, PVL, enterotoxin, exfoliatin
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What helps prevent ingestion by white blood cells?
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Capsules (S. aureus has 11, 5&8 most common)
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What functioins in adherence of G+ bacteria to mucosal surfaces?
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Polysaccharide A (Linear ribitol teichoic acids), also help with antiphagocytic,
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what is protein A?
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Binds to Fc region of IgG molecule, interferes with host's immune system and prevents ingestion of bacteria.
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what is Clumping factor?
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allows cells to bind to platelets, aids in spreaqding of infection
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What are adhesions?
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proteins that allow bacterium to bind to proteins (collagen) and granulocytes,
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Function of Catalase?
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Inactivate H2O2 and free radicals
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Free Coagulase
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coat bacteria with fibrin, renders them resistant to phagocytosis.
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Four types of Hydrolases in S. aureus
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1. Lipases
2. Phospholipase C 3. Hyaluronidase 4. Thermonuclease |
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Lipases
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helps spread the organism in cutaneous and subcutaneous tissues
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Hyaluronidase
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hydrolyzes mucin in connective tissue, allows organism to spread
-90% S. aureus |
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Thermonuclease
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cleaves host DNA and RNA
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Staphylokinase
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dissolves fibrin clots and contributes to spreading of organism from local sites
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Beta Lactamase Enzyme
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cleaves B L ring in penicillin.
Penicillin resitance. Found in 80% of S. aureus |
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Pyrogenic Exotoxins
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toxic shock syndrome toxin 1
stimulates proliferation of T Cells |
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Which Enterotoxins are responsible for Staph Food poisoning?
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A-E, H and I
5.25% of cases |
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Skin Disease of S. aureus
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Furuncle
Carbuncles Impetigo Scalded Skin Syndrome |
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Furuncle
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painful, boil at hair follicle, necrosis, walled of from subcutaneous tissue
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Carbuncle
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Furuncle goes deeper into fibrous tissue, pus discharge
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Impetigo
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Newborns.
usually on face, eyes, lips, nose, limbs |
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Scalded Skin syndrome
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Exofliative toxin
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Respiratory Tract infections of S. aureus
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Bronchopneumonia
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Gi Tract infection of S. aureus
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Food poisoning, staphylococcal colitis, necrotizing enterocolitis
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Female Genital tract infection of S. aureus
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Toxic Shock Syndrome
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Treatment against S. aureus
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Vancomycin
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MRSA/ VISA
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Methicillin resistant S. aureus
Vancomycin intermediate resistant S. aureus. Treatment: tetracycline |
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Disease caused by S. saprophyticus
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UTI.
Adheres to uroepithelial cells more than any other species of Staph. Pus, Blood, Pain in Urine |
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What allows adherence to uroepithelial cells
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Ssp and Hemagglutnin
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