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13 Cards in this Set
- Front
- Back
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Indomethacin
-MOA/PK -Uses -AEs |
NSAID
Acute attack of gout small daily doses-prophylaxis long term AEs |
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Prednisone
-MOA/PK -Uses -AEs |
Corticosteroid for acute gout attack
Long term AEs |
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ACTH
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Only inpatient acute gout attack
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Colchicine
-MOA |
Acute attack
Binds to tubulin-prevent polymerization to form microtubules-inhibits leukocyte migration/phagocytosis-inhibits leukotriene B4 formation |
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Colchicine
-PK/Uses -AEs |
PO every hour until Sx improve/SEs intolerable
Reduce inflammation/pain of gout Low dose prophylaxis Management of mediterranean fever N/V/D Fatal overdoses |
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Allopurinol
-MOA |
Reduces uric acid produxn
Irreversible XO inhibitor, metabolite=alloxanthin-effective inhibitor |
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Allopurinol
-PK/Uses |
PO 1X/Day
Alloxanthinn half-life longer Liver metabolism Hyperuricemia Rx SAFE for renal dysfxn w/caution |
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Allopurinol
-AEs |
Early-increased risk of gout, increase dose slowly
Skin rash, allergic rxns GI disturbances Peripheral neuropathy Bone marrow suppression Hepatic toxicity Interstitial nephritis Drug interaxn-azathioprine, mercaptopurine |
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Probenicid
-MOAs |
Urosuric agent-enhances uric acid elimination
Secreted/reabsorbed in prox. tubule, competes w/UA for anionic transport sites, decreased reabsorption Inhibit secretion of other weak acids (Penicillin, MTX) |
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Probenicid
-Uses |
Chronic gout
NOT for renal dysfxn Not used in pt already secreting larges amts of uric acid |
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Aspirin
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Contraindicated in gout
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Uricase enzymes
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Metabolize uric acid to allantoin
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Febuxostat
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Nonpurine selective inhibitor of XO
PO Safe for renal dysfxn, allopurinol allergy Liver fxn abnormalities Headaches GI upset |
