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23 Cards in this Set
- Front
- Back
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Estradiol, Estrone and Estriol are _______?
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natural estrogen
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Ethinyl Estradiol, and Mestranol are ______?
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Synthetic Steroidal
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Diethylstilbestrol and Dienestrol are ____?
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Synthetic Non-steroidal
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Estrogens (increase/decrease)the synthesis of II, VII, IX, X, fibrinogen and (increase/decrease) anti-thrombin
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increase; decrease
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Estrogen – continuous exposure leads to _________
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hyperplasia of endometrium
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Adverse Effects of estrogen?
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↑ risk of myocardial infarction, stroke, gall stones and pulmonary embolism
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_____________ Acts as a competitive inhibitor at estrogen receptor.
It decrease the negative feedback of estrogen on hypothalamus / pituitary and increase FSH / LH secretion |
Clomiphene
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This is used as ovulation inducing drug
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Clomiphene
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What is Tamoxifen?
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It is a partial agonist at estrogen receptor.
Agonist on bone and lipid metabolism. Antagonist on breast. |
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What is Raloxifene?
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Agonist on bone and lipid metabolism.
Antagonist on endometrium and breast. Does not cause endometrial cancer |
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__________is a selective inhibitor of aromatase and thus ↓estrogen synthesis
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Anastrozole
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Fourth generation progestin?
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Drospirenone
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Clinical uses of progestin?
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Hormonal replacement therapy
Contraception |
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Adverse effects of progestin?
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Breakthrough bleeding
Hirsuitism and acne (androgenic) Abnormal lipid and glucose levels. |
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________is widely used to terminate early pregnancy
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Mifepristone
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Two types of birth control pills?
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They are of two types :
Estrogen and Progestin Progestin Only |
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Monophasic oral contraceptives?
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They contain same amount of estrogen and
progestin throughout the cycle |
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Biphasic and Triphasic oral contraceptives?
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These contain variable amount of estrogen
and progesterone in phases |
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What is danazol?
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It is a weak androgen, derivative of testosterone which has anti-estrogenic activity
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clinical uses of androgens?
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Hypogonadism.
Endometriosis. Anemia. Osteoporosis. Aging |
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adverse effects of androgens?
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Adverse effects :
Hirsutism, acne, deepening of voice. Cholestatic jaundice. |
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__________are used in the treatment of prostate
cancer and male pattern baldness |
Anti-androgens
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Finasteride :
Orally active and inhibits _______ producing a reduction of dihydrotestosterone in prostate and skin |
5-α-reductase -II enzyme
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