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20 Cards in this Set
- Front
- Back
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What is the most common blood group?
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Group O
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What antibodies are present in most people with group O blood (2)?
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1) anti-A IgG
2) anti-B IgG |
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Why do circulating antibodies develop against these blood group antigens?
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The antigens are present in food and are presented to B-lymphocytes in Peyer's patches.
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Forward typing detects blood group ______, whereas back typing detects blood group _______.
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a) antigens
b) antibodies |
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What are the five Rh antigens?
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D, C, c, E, e
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An individual who is Rh positive is ____ antigen positive.
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D
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Atypical antibodies produced against foreign antigens not present on patients RBCs may produce a ______ ________ reaction.
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a) hemolytic
b) transfusion |
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What is the most common pathogen transmitted by transfusion?
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CMV present in donor lymphocytes
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Why must blood transfusions for newborns be irradiated?
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To kill lymphocytes that may contain CMV.
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What blood group are universal donors?
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Group O b/c they lack antigens
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What blood group are universal recipients?
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Group AB because they lack antibodies.
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Allergic transfusion reactions are (IgE/IgG/IgM) _____-mediated.
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IgE
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What is the major cause for febrile transfusion reaction?
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Anti-HLA antibodies against donor leukocytes.
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Acute hemolytic transfusion reactions are due to _____ ______ incompatibility or presence of _____ antibodies.
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a) blood group
b) atypical |
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What is the most common hemolytic disease of the newborn?
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ABO incompatibility due to passive immunization with mother's IgG antibodies
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What is the most common cause of jaundice within the first 24 h after birth?
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ABO hemolytic disease of the newborn
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What test of cord blood will be positive in ABO hemolytic disease of the newborn?
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Direct Coomb's test with fetal RBCs
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(True/False) Symptoms of hemolytic disease of newborn are worse with ABO incompatibility as compared to Rh incompatibility?
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False
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Rh incompatibility may lead to unconjugated hyperbilirubinemia. What clinical problem is of major concern in this situation?
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Kernicterus, deposition of lipid soluble bilirubin in the basal ganglia.
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What can be used to convert bilirubin in skin to water-soluble dipyrrole?
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Blue fluorescent light.
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