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13 Cards in this Set
- Front
- Back
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In the most common mutation leading to the development of Cystic Fibrosis, what organelle does not correctly process the CFTR channel, leading the the channel's destruction?
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The Golgi does not properly process it and this leads to the destruction of the CFTR channel. The most common mutation is F508.
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What part of the nephron is the most sensitive to ischemic injury?
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The straight portion of the proximal tubule.
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What changes happen first when a cell experiences hypoxia in terms electrolytes?
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Oxidative phosphorylation is shut down in the mitochondria and so the cell stops making ATP. Lack of ATP decreases Na+/K+ pump and sodium is allowed to move into the cell, along with H2O and the cell swells.
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When does Non-disjunction in gametogenesis normally occur and what are the chromosomal patterns that can result?
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Non-disjunction normally occurs in Meiosis I and it can result in 22 or 24 chromosomes.
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Give an example of an eye disease caused by a maternally inheritable genetic defect in mitochondria?
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Lerbers Optic neuropahty.
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What effect does the increased estrogen of pregnancy have on the production of binding globulins?
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Estrogen increases the production of binding globulins such as Thyroid BG and Cortisol BG.
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Myomatous degeneration of the mitral valve causing mitral valve prolapse is caused by the increased deposition of what GAG in the tissue?
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Dermatan sulfate depostion.
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Opening SNAP! followed by mid-diastolic rumbling characterizes what valvuar lesion, with what most common cause?
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This characterized mitral stenosis, which is most commonly caused by rheumatic heart disease.
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Diastolic blowing murmur after S2 is what?
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Aortic Regurgitation.
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Pansystolic murmur heard at the apex is what?
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Mitral valve regurgitation.
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Systolic ejection murmur means what?
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Aortic stenosis.
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What is the most common cause of hemolytic anemia associated with shistocytes?
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Aortic stenosis.
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In AIDs patients, what viral infection is the most common cause of blindness, biliary tract disease, and pancreatitis?
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CMV infection.
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