Goljan Musculoskeletal

Front 1

Osteogenesis Imperfecta

Back 1

AD, defective type I collagen synthesis, blue sclera, deafness, pathologic fractures, Bisphosphonates is treatment

Front 2

Achondroplasia

Back 2

AD, mutation in fibroblast growth factor (associated with icnreased paternal age) impaired proliferation of catilage at growth plate, normal head, short arms and legs

Front 3

Osteopetrosis

Back 3

AR (severe), AD (less severe) deficiecny of osteoclasts, overgroswth of cortical bones, pathologic facture, anemia and CN entrapment

Front 4

Osteomyelitis

Back 4

usually d/t sepsis. Most common in metaphysis, major pathogen is staph aureus, fever nboen pain, diagnosis by biopsy

Sickle cell disease- salmonella paratyphi, pseudomonas aeruginosa most often d/t puncture of foot through rubber footwear

Front 5

Osteoperosis secondary causes

Back 5

Underlying disease (hypercortisolism), drugs, hypogonaidsm, malnutrition... space travel

Front 6

Legg-Calve-perthes Dz

Back 6

aseptic necrosis of femoral ossification center, males 3-10 y/o, knee pain or limp, secondary osteoarthritis

Front 7

OSteocohondritis dissecans- variant of osteochonrosis of articular epiphysis

Back 7

variant of osteochonrosis of articular epiphysis, trauma, primary insult with ischemia seocondary, most often distal femur

Front 8

Paget's disease

Back 8

mostly men over 50, osteoclastic phase folowed by osteoplastic phase, elevated alk phos in osteoblastic phae -> weak thick, vascular bone can lead to ostegenic sarcoma

Front 9

Fibrous dysplasia

Back 9

defect in osteoblast differentiation and maturation, medullary bone displaced by fibrous tissue, pain and swelling of bone

Front 10

Albright's syndrome

Back 10

polyostotic bone involvmement, dafe-au-lait spots, precoccious sexual develoment