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12 Cards in this Set

  • Front
  • Back
The critical area to control cell cycle
G1 to S phanse = G1 checkpoint
Most variable phase in cell cycle
G1 phase
Rb suppressor gene is on chromosome__
13
Prevents cell from going from G1 to S phase
Rb suppressor gene on chromosome 13 and p53 suppressor gene
what causes inhibition of cyclin-dependent kinase 4 (Cdk4) and what does this do?
TP53 suppressor gene - inhibits CdK4 preventing Rb protein phosphorylation which would allows Rb protein to remain active and thus arresting cell in G1 phase, allowing time for DNA repair if it is possible
If excessive DNA damage has occured in cell what is activated? what does it do?
BAX gene is activated by TP53 and BASX inhibits BCL2 antiapoptosis gene, causing release of cytochome C from mitochondira -> apoptosis
Kinase always means what?
Phosphorylation (for some that means inactivation and some it causes activation)
t(8;14)
Burkitt's lymphoma
- c-myc activation on chromosome 8
- associated with HIV and EBV
t(14;18)
Follicular lymphoma
- involving BCL-2 activation (anti-apoptosis)
t(11;24)
Mantle cell lymphoma
- usually fatal;
- occurs in adults
- cells resemble mantle zone cells that surround follicular center
Auer bodies
Acute Myelogenous leukemia (AML - M3)
Bence Jones proteinuria
Multiple Myeloma