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12 Cards in this Set
- Front
- Back
The critical area to control cell cycle
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G1 to S phanse = G1 checkpoint
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Most variable phase in cell cycle
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G1 phase
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Rb suppressor gene is on chromosome__
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13
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Prevents cell from going from G1 to S phase
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Rb suppressor gene on chromosome 13 and p53 suppressor gene
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what causes inhibition of cyclin-dependent kinase 4 (Cdk4) and what does this do?
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TP53 suppressor gene - inhibits CdK4 preventing Rb protein phosphorylation which would allows Rb protein to remain active and thus arresting cell in G1 phase, allowing time for DNA repair if it is possible
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If excessive DNA damage has occured in cell what is activated? what does it do?
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BAX gene is activated by TP53 and BASX inhibits BCL2 antiapoptosis gene, causing release of cytochome C from mitochondira -> apoptosis
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Kinase always means what?
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Phosphorylation (for some that means inactivation and some it causes activation)
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t(8;14)
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Burkitt's lymphoma
- c-myc activation on chromosome 8 - associated with HIV and EBV |
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t(14;18)
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Follicular lymphoma
- involving BCL-2 activation (anti-apoptosis) |
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t(11;24)
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Mantle cell lymphoma
- usually fatal; - occurs in adults - cells resemble mantle zone cells that surround follicular center |
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Auer bodies
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Acute Myelogenous leukemia (AML - M3)
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Bence Jones proteinuria
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Multiple Myeloma
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