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10 Cards in this Set
- Front
- Back
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What is a glycoprotein IIb/IIIa ?
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An enzyme needed for platelet aggregation.
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What do glycoprotein IIb/IIIa inhibitors do?
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The bind to the major platemt surface recepto invloved in platelet aggregation. Prevent the binding of fibrin.
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What is the advantage of a glycoprotein IIb/IIIa inhibitor?
What is the disadvantage? |
Most effective antiplatelet agent.
Very expensive and can only be given IV |
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Abciximab
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Reopro
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Integrilin
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Eptif
Eptifibatide |
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Tirofibran
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Aggrastat
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How does Abciximab work?
Dosing? |
Inhibits platelet aggregation by preventing binding of fibrin to VonWillebrands factor and other molecules
.25 mg/kg bolus, then 0.125 mcg/kg/min for > or = to 12 hours |
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What is Integrilin dose?
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135-180 mg/kg IV, then
.5 - 2 mcg/kg/min for up to 72 hours |
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Tirofibran
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.4 mcg/kg/min x 30 minutes IV, then
0.1 mcg/kg/min x 12-24 hours IV |
