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19 Cards in this Set

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  • Back
What is the cofactor of all kinases used in glycolysis?
What is the 1st step in Glycolysis?
Glucose + (Hexokinase/Mg2+) --ATP--> Glucose-6 phosphate +ADP
What is Step 2 of Glycolysis?
Glucose-6 phosphate + Phosphoglucose Isomerase ---> Fructose-6 phosphate
What is step 3 of Glycolysis?
Fructose-6 phosphate + Phosphofructokinase/Mg2+ --ATP--> Fructose-1,6 bisphosphate + ADP
What is step 4 of Glycolysis?
b-D-Fructose-1,6 bisphosphate + Fructose Bisphosphate Aldolase ----> dihydroxyacetone phosphate and glyceraldehyde 3-phosphate.
Why put a phosphate on a glucose?
1. It "locks" the glucose in the cell, since there are no phosphoglucose channels.
2. It keeps the concentration of free glucose in the cell low, so that more keeps flowing in.
At what point does glycolysis effectively become "irreversible"?
Step 3, yielding Fructose 1,6-bisphosphate.
Why is Step 3 considered irreversible?
The energy put into it destabilizes the molecule, forcing the rxn forward.
What is step 6 of Glycolysis?
glyceraldehyde 3-phosphate + glyceraldehyde phosphate dehydrogenase ---Pi--NAD+--> 1,3-bisphosphoglycerate + NADH
What is Step 5 of glycolysis?
Dihydroxyacetone phosphate + triosephosphate isomerase -----> D-glyceraldehyde 3-phosphate
What is the 7th step of glycolysis?
1,3-Bisphosphoglycerate + Phospholycerate Kinase/Mg2+ ---ADP---> 3-Phosphoglycerate + ATP
What is the 8th step of glycolysis?
3-Phosphoglycerate + Phosphoglycerate Mutase ----> 2-Phosphoglycerate
What is he 9th step in glycolysis?
2-Phosphoglycerate + Enolase/Mg2+ -----> Phosphoenolpyruvate
What's the final step in Glycolysis?
Phosphoenolpyruvate + Pyruvate Kinase/Mg2+ --ADP--> Pyruvate + ATP
Describe regulation of glycolysis via hexokinase/ glucokinase.
When [glucose-6-phosphate] are high, hexokinase's activity is allosterically inhibited; hexokinase works best at low [glucose]. When [glucose] is high, glucokinase is activated and its glucose-6-phosphate product is stored as glycogen.
Which steps yield ATP?
Steps 7 & 10
Which step yields reduced NADH?
Step 6
What is the net yield from 1 glucose in glycolysis?
2 ATP, 2 NADH, 2 pyruvte
What are the possible fates of pyruvate?
Fermentation or enters the TCA cycle.