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25 Cards in this Set
- Front
- Back
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What is one of the three IRREVERSIBLE steps of glycolysis?
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Hexokinase/glucokinase
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What is the difference between hexokinase and glucokinase?
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Hexokinase is everywhere and glucokinase is found in the liver.
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Hexokinase has the lower_______, therefore the higher _______.
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Km, affinity
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What is one of the three IRREVERSIBLE steps of glycolysis?
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PKF-1, this is the major regulatory enzyme of glycolysis
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What is inhibited by ATP, Low pH, citrate glucagons?
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PKF-1
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What is stimulated by AMP, ADP, and insulin?
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PKF-1
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PKF-1 is stimulated by what?
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AMP, ADP, and insulin
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PFK-1 is inhibited by what?
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ATP, Low pH, citrate
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What two steps in glycolysis require the use of ATP
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Hexokinase/glucokinase and PFK-1
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What two steps in glycolysis produce ATP by substrate level phosphoryation?
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Phosphoglycerate kinase and Pyruvate kinase
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What step produces NADH?
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G3P dehydrogenase
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G3P dehydrogenase produces what in glycolysis?
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NADH
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Hemolytic anemia is a result of...
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Pyruvate kinase deficiency
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What inhibits enolase and causes the inhibition of glycolysis?
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Fluoride ions
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By inhibiting enolase you also inhibit what pathway?
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glycolysis
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In a situation where glycolysis continues to produce pyruvate w/ no ATP, what kind of poisining has occured?
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Arsenate poisining
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Arsenate poisining causes...
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uncoupling of substrate level phosphorylation
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Pyruvate dehydrogenase (PDH) is stimulated by what?
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Pyruvate, NAD, AMP, CoA
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Pyruvate, NAD, AMP and CoA stimulates what under aerobic conditions?
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Pyruvate dehydrogenase (PDH)
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Pyruvate dehydrogenase (PDH) is inhibited by what?
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NADH, acetyl-CoA
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Thiamine deficiency causes what type of condition?
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Wernicke-Korsakoff syndrome
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Arsenite inhibits what?
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Pyruvate dehydrogenase (PDH)
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What five co-enzymes are needed for Pyruvate dehydrogenase?
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Thiamine pyrophosphate, NAD, FAD, Lipoic acid, Coenzyme A
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What occurs under anaerobic conditions durring glycolysis?
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Lactate dehydrogenase (LDH)
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What is the most common type of metabolic acidosis?
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Lactic acidosis
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