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9 Cards in this Set
- Front
- Back
- 3rd side (hint)
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Presentation |
-0.6 mg tablets -transdermal GTN patch (50 mg 0.4 mg/hr release |
Tablet & patch |
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Pharmacology |
Principally, a vascular smooth muscle relaxant |
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Actions |
-venous dilatation promotes venous pooling and venous return to the heart (reduces preload) -arterial dilatation reduces systemic vascular resistance and arterial pressure (reduces afterload)
The effects of the above are: -reduced myocardial 02 demand -reduced systolic, diastolic, and mean arterial pressure, whilst usually maintaining coronary perfusion pressure -mild collateral coronary arterial dilatation may improve blood supply to Ischemic areas of myocardium -mild tachycardia secondary to slight fall in blood pressure -preterm labour: uterine quiescence in pregnancy |
2 + 5 effects of the actions |
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Metabolism |
By the liver |
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Indications |
-chest pain with ACS -acute LVF -hypotension associated with ACS -autonomic dysreflexia -preterm labour (consult) |
5 |
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Contraindications |
-known hypersensitivity -systolic blood pressure -systolic blood pressure -viagra/levitra in the past 24 hours or cialis in the past 4 days -heart rate >150 -bradycardia -VT -inferior STEMI with systolic BP -right ventricular MI
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9 |
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Precautions |
-no previous administration -elderly patients -recent MI -concurrent use with other tocolytics |
5 |
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Side effects |
-tachycardia -hypotension -headache -skin flushing (uncommon) -bradycardia (occasionally) |
5 |
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Onset/peak/duration |
S/L (tablet) Onset: 30 seconds - 2 minutes Peak: 5 - 10 minutes Duration: 15 - 30 minutes
Transdermal (patch) Onset: up to 30 minutes Peak: 2 hours |
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