Glutathione

Front 1

Name the three amino acids which can be used by the body to synthesize glutathione.

Back 1

1. l-glutamic acid
2. glycine
3. l-cysteine

Hint 1

https://en.wikipedia.org/wiki/Glutathione

http://www.huffingtonpost.com/dr-mark-hyman/glutathione-the-mother-of_b_530494.html

Front 2

The reduced form of glutathione is

Back 2

GSH

Front 3

In the reduced form it can donate a reducing equivalent to

Back 3

unstable molecules such as reactive oxygen species

Front 4

the oxidized form of glutathione is

Back 4

GSSG

Front 5

GSR (glutathione reductase) can regenerate

Back 5

GSH from GSSG

Front 6

The glutathione pool of healthy people have over 90% of the total glutathione as

Back 6

GSH

Front 7

An increase in GSSG above 10% of the total glutathone indicates

Back 7

oxidative stress such as free radicals and peroxides

Front 8

The ratio of reduced glutathione (GSH) to oxidized gluthione (GSSG) is considered a measure of

Back 8

cellular toxicity

Front 9

Glutathione is synthesized in two steps which involve

Back 9

adenosine triphosphate (ATP)

Hint 9

see ATP (adenosine triphosphate) flashcards for more info regarding ATP metabolic pathways and ATP recycling

Front 10

The first step, which is rate limiting in the biosynthesis of glutathione (GSH) is the synthesis of gamma-glutamylcysteine from l-glutamate using gamma-glutamylcysteine synthetase which is also known as

Back 10

gamma-glutamylcysteine synthetase or GCL

Front 11

The second step in the biosynthesis of glutathone involves the addition of gamma-glutamylcysteine via the enzyme

Back 11

glutathione synthetase