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6 Cards in this Set
- Front
- Back
describe gluconeogenesis and key enzymes, and their regulation.
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Pyruvate is converted to OAA via PYRUVATE CARBOXYLASE enzyme [+ Acetyl CoA]. OAA is converted to PEP via PEPCK [I by glucagon, epinephrine, & glucocorticoids]. PEP is converted to G3P & DHAP which are then condenced to form Fructose 1,6 Biphosphate. FRUCTOSE 1,6 BISPHOSPHATE [ - by F=2,6-p; I by fasting] converts it to Fructose 6-phosphate which is thenconverted to glucose 6 phosphate which is then converted to glucose via GLUCOSE 6-PHOSPITASE [I by fasting]
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Hepatic Glycolytic enzymes & regulation
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Glucokinase
high Km for glucose I by insulin Phosphofructokinase +F2,6P & AMP Pyruvate Kinase + by F1,6 P -ATP -Alanine - by phosphorylation (glucagon & epinephrine raise cAMP levels and activate protein kinase A) |
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gluconeogenic enzymes & regulation
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Pyruvate carboxylase
+Acetyl CoA PEPCK Induced by glucagen and epinephrine Repressed by insulin Fructose 1,6 bisphoshatase - by F2,6-P I during Fasting Glucose-6 phosphatase I during fasting |
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1)where is malate shuttle?
2)Where is Gly3P shuttle |
1)liver
2)mm |
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Describe Cori Cycle
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In glycogen world glucose is expensive. We take glucose in RBC and get 2 ATP to feed RBC turn it into lactate & pyruvate to recycle C backbone. By doing this we conserve protein.
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Cahill Cycle
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Also conservation cycle uses alanine instead of lactate.
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