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5 Cards in this Set
- Front
- Back
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Gluconeogenesis
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The process in which glucose is formed from noncarbohydrate precursors (lactate, pyruvate, oxaloacetate)
- 7 steps use same enzymes as glycolysis, and are reversible - 3 steps are irreversible |
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3 Irreversible Glycolytic Steps (and how gluconeogenesis gets past them)
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1. Pyruvate to PEP via oxaloacetate
2. Dephosphorylation of F-1,6-BP 3. Dephosphorylation of G6P - Entire process takes 4 ATP, 2 GTP, 2 NADH - Done in Liver, Kidney, and small intestine |
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Pyruvate -> PEP
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Pyruvate Carboxylase
- Pyruvate + Bicarbonate + ATP -> Oxaloacetate PEP Carboxylase - Oxaloacetate + GTP = Phosphoenolpyruvate |
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Oxaloacetate and Membranes
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Oxaloacetate can not pass the membrane; 2 options
1. Asparate 2. Malate |
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Dephosphorylation of F-1,6-BP & G6P
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Dephosphorylated by membrane proteins
- Hydrolysis - atase ending |
