Glucagon

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GLUCAGON
Class/MOA

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Class
Hyperglycemic agent, pancreatic hormone, insulin antagonist.
Mechanism of Action
Increases blood glucose by stimulating glycolysis.
Unknown mechanism of stabilizing cardiac rhythm in beta-blocker overdose.
Minimal positive inotrope and chronotrope.
Decreases GI motility and secretions.

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GLUCAGON
Indications

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Indications
Altered level of consciousness when hypoglycemia is suspected.
May be used as inotropic agent in beta-blocker toxicity.

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GLUCAGON
Contraindications

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Contraindications
Hyperglycemia
Hypersensitivity

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GLUCAGON
AR

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Adverse Reactions
Nausea
vomiting
Tachycardia
hypertension

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GLUCAGON
DI

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Drug Interactions
Do No Mix with Saline

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GLUCAGON
How supplied

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How Supplied
1 mg ampules (requires reconstitution with diluent provided)

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GLUCAGON
dosage and administration

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Dosage and Administration
Adult: 0.5 -1 mg IM, SC, or slow IV, may repeat q 20 minutes PRN.
Pediatric: 0.03 - 0.1 mg / kg / dose (not to exceed 1 mg) q 20 min. IM, IO, SC, slow IV

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GLUCAGON
DOA

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Duration of Action
Onset: 1 min
Peak effect: 30 minutes
Duration: Variable

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GLUCAGON
Specials

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Special Considerations
Pregnancy safety: Category C.
Ineffective if glycogen stores depleted.
Should always be used in conjunction with 50% dextrose whenever possible.
If patient does not respond to second dose glucagon, 50% dextrose must be administered.