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9 Cards in this Set
- Front
- Back
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Mesangial IgA immune complex w/ granular immunoflourescence.
Most common world wide Kids, Adults and Heavy Smokers Episodic bouts of hematuria following URI w/ slow progression to CRF |
IgA glomerulopathy (nephritic)
Berger's Disease |
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SubEpithelial immune complexes w/ granular immunoflourescence.
Lumpy Bumpy type III Hypersensitivity |
Post-Streptococcal Glomerulonephritis (nephritic)
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SubEndothelial immune complex deposits w/ granular immunoflourescence.
Wire Looping of capillaries Anti-dsDNA immune complexes activate Classical pathway Most common glomerular disease in SLE |
Diffuse Proliferative Glomerulonephritis (nephritic)
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Begins w/ Hemoptysis and progresses to ARF w/ very poor prognosis
Often associated w/ Crescent formation surrounding glomeruli Clinical Associations: Goodpastures, Microscopic Polyarteritis (p-ANCA), Wegener's (c-ANCA) |
Rapidly Progressive Crescentric Glomerulonephritis (nephritic)
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Most common in children
Selective proteinuria (decrease in Albumin) - GBM loses its negative charge due to T-cell Cytokines Electon Microscopy shows Fusion of Podocytes Secondary cause is Hodgkin's Lymphoma Often preceded by respiratory infection |
Minimal Change disease (Nephrotic)
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Most common in HIV pts and Intravenous Heroin abuse
Microscopic Hemauturia Poor prognosis progress to CRF |
Focal Segmental Glomerulosclerosis (Nephrotic)
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Most common Nephrotic in Adults
Diffuse thickening of membranes - Silver Stain shows "Spike and Dome" subEpithelial deposits SubEpithelial immunecomplexes with Granular immunoflourescence Secondary Causes: Drugs - Captopril Infections - HBV, Malaria, Syphilis Malignancy - Carcinomas, Hodgkins Lymphoma Autoimmune- SLE |
Diffuse Membranous Glomerulopathy (Nephrotic)
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Associated w/ Hep B and Hep C
SubEndothelial Immunecomplexes activate classical and alternative pathways Tram tracking caused by splitting of the GBM by mesangium Majority progress to CRF |
Type 1 Membranoproliferative Glomerulonephritis
most common type |
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Associated w/ C3 nephritic factor causing sustained activation of C3 resulting in very low C3 levels
Diffuse intramembranous deposits - "Dense Deposits Disease" EM shows Tram Tracks Majority progress to CRF |
Type II Membranoproliferative Glomerulonephritis
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