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31 Cards in this Set
- Front
- Back
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LM show glomeruli that are enlarged & HYPERcellular + neutrophils = lumpy bumpy
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poststreptococcal glomerulonephritis
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EM: subEPIthelial immune complex deposits
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poststreptococcal glomerulonephritis
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poststreptococcal glomerulonephritis is what type of hypersensitivity
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III - immune complex
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child
peripheral & periorbital edema nephritic |
poststreptococcal glomerulonephritis
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crescent moon shape on LM and IF & nephritic
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rapidly progressive glomerulonephritis
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what is contained in the crescents of RPGN?
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fibrin + plasma proteins w/glomerular parietal cells, monocytes, MP
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Which diseases can lead to RPGN?
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goodpasteur, wegners (c-ANCA), microscopic polyarteritis (p-ANCA)
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hematuria + hemoptysis
linear pattern of IF + nephritic |
Goodpasteurs - Type II anti-GBM antibodies
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subENDOthelial DNA-anti-DNA immune complexes
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diffuse proliferative glomerulonephritis due to SLE
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most common cause of death in SLE patients
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diffuse proliferative glomerulonephritis
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wire looping of capillaries
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diffuse proliferative glomerulonephritis due to SLE
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after UTI --> increased synthesis of IgA with immune complex deposits seen in MESANGIUM
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Berger's disease (IgA glomerulopathy)
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lack of type IV collagen --> split BM
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Alport's syndrome
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What are other complications of alport's syndrome
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nerve disorder, ocular disorders, deafness
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What is a hematological consequence of nephrotic syndrome?
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thromboembolism
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Why is someone with nephrotic syndrome at higher risk for getting infection?
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loss of immunoglobulins
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MCC glomerulonephritis in adults
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diffuse membranous glomerulonephritis
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LM: diffuse capillary & GBM thickenin
EM: spike and dome with supEPIthelial deposits nephrotic |
diffuse membranous glomerulonephritis
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MC glomerulonephritis in children
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minimal change disease
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How do you treat minimal change disease?
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corticosteroids
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EM: foot process effacement (fusion of podocytes)
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minimial change disease
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How come in Minimal change disease you only see loss of albumin?
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GBM polyanion loss (heparan sulfate charge loss)
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LM: Congo red stain with apple-green birefringce
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amyloidosis
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What kind of protein is in kidney amyloidoses?
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lambda light chain - assoc with multiple myeloma, chronic conditions, TB, rheumatoid arthritis
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What is the pathogenesis of diabetic glomerulonephropathy
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nonenzymatic glycosylation of GBM --> increase perm and thickening
NEG of efferent arterioles leads ot increase GFR and mesangial expansion |
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LM: mesangial expansion,GBM thickening, Kimmelstiel wilson lesions
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diabetic glomerulonephropathy
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segmental sclerosis and hyalinosis in and HIV patient + nephrotic
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focal segmental glomerulosclerosis
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subENDOthelial deposits w/granular IF + tram track of GBM (mesangial growth)
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membranoproliferative glomerulonephritis I
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subENDOthelial deposits w/granular IF + dense deposits on EM
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membranoprolifeartive glomerulonephritis II
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assoc with HBV
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membranoproliferative glomerulonephritis I
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assoc with C3 nephritic factor (autoantibody against it)
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membranoproliferative glomerulonephritis II
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