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15 Cards in this Set
- Front
- Back
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Minimal Change Nephrotic Syndrome Pathogenesis???
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Circulating factor???
Loss negative charge on feet=breakdown glomerular barrier |
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Minimal change nephrotic syndrome Treatment?
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Antiinflammatory meds like prednisone
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Diagnosis of Minimal Change???
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PRESENATION. Biopsy is not necessary
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Membranous Nephropathy Pathogenesis???
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Deposition of immune complexes along the GBM.
Antigen is unknown Exogenous or endogenous??? |
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Membranous nephropathy Clinical presentation???
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Nephrotic syndrome
Late: High BUN, serum creatinine rises |
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Treatment of Membranous Nephropathy???
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Spontaneous remission
Progressive kidney failure if high proteinuria Immunosuppressive medications >>>Prednisone, cyclophosphamide, chlorambucil. |
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Focal Segmental Glomerulosclerosis Pathogenesis???
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Podocyte is damaged=defects in slit diaphragms
~nephrin in Finnish acquired form=a mystery) *’acquired: recurs after transplant=circulating toxin (permeability factor) |
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Focal Segmental Glomerulosclerosis Clincal Findings???
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Like minimal change disease
except that there is progressive kidney failure. |
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Pathogenesis of Diabetic Nephropathy
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Damage is not immune mediated
Glyosylation of tissue proteins Hyperfiltration Systemic hypertension |
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Clinical findings Diabetic Nephropathy?
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Early: Microalbuminuria,
Progressive increase in protein iexcretion >>nephrotic syndrome and Kid failure |
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Light microscopy findings of diabetic nephropathy?
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Expansion of mesangial matrix
---Kimmelstiel-Wilson nodules Uniform thickening of capillary walls Hyaline deposits in afferent/efferent arteriole |
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Electron microscopy of diabetic nephropathy
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GBM thickening
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Pathogenesis of Renal Amyloidosis???
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Deposition of protein fibrils
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Clinical Findings of Renal Amyloidosis???
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Proteinuria (nephrotic range)
Kidney disease varying extents AL amyloid: light chains (PLASMA CELL NEOPLASIA) AA: acute phase protein AA (CHRONIC INFLAMMATION) |
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Light microscopy of Renal Amyloidosis???
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Glomeruli, interstitium around tubules, blood vessels have deposition of amyloid.
Eosinophil and amorphous Stain congo red=look greenish crystal violet LOOKS LIKE SAUSAGE TO ME |
