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15 Cards in this Set
- Front
- Back
- 3rd side (hint)
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CB<20% Urine bilirubin is absent Urine UBG is increased. Pathology? |
Extrahemolytic anemia I.e. hereditary spherocytosis, RH and ABO |
Unconjugated hyperbilirubinemia |
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CB<20% Decreased uptake or conjugation of UCB Urine bilirubin is absent Pathology? |
Gilbert's syndrome (jaundice w/ stress menses fasting etc) Physiologic jaundice in babies (day 3, Normal destruction of rbcs w/ HbF by macrophages) Breast milk jaundice Criggler najjar |
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CB 20-50% Urine bilirubin high Urine UBG high Pathology? |
Viral hepatitis, defect in uptake and conjugation of UCB, secretion of CB |
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Obstructive CB >50% Urine bilirubin high Urine UBG absent Pathology? |
Decreased extra hepatic bile flow: gallstone in CBD, carcinoma in head of pancreas
Decreased intrahepatic bile flow: Primary biliary cirrhosis, drug induced (OCPs) |
Unconjugated hyperbilirubinemia |
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ALT higher than AST. Viral or alcoholic hep? |
Viral. In alcoholic AST is higher. Mitochaundria damaged. |
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LFT: Serum ALT |
Specific for liver cell necrosis. Present in cytoplasm. High in viral hepatitis. |
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LFT: Serum AST |
AST> ALT in alcoholic hepatitis Produced in mitochaundria |
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LFT: Cholestasis Gamma glutamyltransferase |
High in intra/ extrahepatic obstruction to bile flow Induction of CYP450 by alcohol increases it. |
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LFT Cholestasis Serum ALP |
Normal GGT and high ALP means source is other than liver. Osteoblastic activity in bone. If both are high. Pathology in liver. |
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GGT and ALP are synthesized in |
Bile duct epithelium |
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Serum Albumin Hepatocyte function |
Hypoalbuminemia in severe liver disease |
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Hepatocyte function PT high |
Coagulation factors synthesized in liver. Severe liver disease will cause high PT. |
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Hepatocyte function Factor V |
Decreased in severe liver disease |
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Hepatocyte function BUN |
Urea cycle in liver. If BUN is decreased- cirrhosis and fulminant hepatitis |
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Hepatocyte function Serum ammonia |
Ammonia is metabolized in liver. High in liver cirrhosis, reye's syndrome. |
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