Ginandtonic

Front 1

SLE criteria

Back 1

4 skin:
butterfly rash
CCLE
photoeruption
oral ulcers

Neuro
Immune
ANA
Kidney
Serositis
Heme
Arthritis

Front 2

Urticarial Vasculitis 70% afflicted are

Back 2

women

Front 3

Schnitzler’s Syndrome:

Back 3

episodes of urticarial vasculitis that occur in association with monoclonal IgM M

Front 4

Nodular Vasculitis Women between

Back 4

30 and 40

Front 5

Livedoid Vasculitis (Atrophie Blanche)Associated with

Back 5

arteriosclerosis or stasis

Front 6

Erythema induratum:

Back 6

form of nodular vasculitis associated with M. Tuberculosis

Front 7

Urticarial Vasculitis tx

Back 7

dapsone, H1 blockers, indomethacin, colchicine

Front 8

Erythema Elevatum Diutinum tx

Back 8

Dapsone

Front 9

Nodular Vasculitis tx

Back 9

NSAIDs, colchicine, systemic steroids

Front 10

Livedoid Vasculitis tx

Back 10

Aspirin, dipyridamole, colchicine, low-dose heparin, systemic glucocorticoids, and low molecular weight dextran, nifedipine, pentoxyfylline

Front 11

Cryoglobulinemia Type I aasoc w

Back 11

b-cell malignancy such as myeloma or lymphoma CLL and Waldenstrom’s macroglobulinemia

Front 12

Type II (Mixed Cryoglobulinemia) etiol

Back 12

Monoclonal IgM rheumatoid factor complexed with polyclonal IgG

Front 13

Type II (Mixed Cryoglobulinemia) dzs

Back 13

Multiple myeloma,Waldenstrom’s, CLL, rheumatoid arthritis, Sjogren’s, Hepatitis C

Front 14

Type III (Mixed Cryoglobulinemia) Often complement activated and complement levels are

Back 14

lower

Front 15

Type III (Mixed Cryoglobulinemia) assoc with
1. what CTDs
2. what GI dz
3. what virus

Back 15

SLE, RA, Sjogren’s, infectious mononucleosis, CMV infection, primary biliary cirrhosis, Hepatitis B

Hint 15

None

Front 16

Essential Mixed Cryoglobulinemia

Back 16

Cryoglobulins and the manifestation of symptoms without an identifiable connective tissue, neoplastic, or

Front 17

Cryofibrinogenemia Associated with

Back 17

malignancy, thromoembolic disease, diabetes, pregnancy, oral contraception, pseudotumor cerebri

Front 18

ACANTHOSIS NIGRICANS among obese children

Back 18

28%

Front 19

ACANTHOSIS NIGRICANS in Native Americans

Back 19

32%

Front 20

ACANTHOSIS NIGRICANS adult patients treated for obesity

Back 20

74%

Front 21

ACANTHOSIS NIGRICANS Associated Conditions

Back 21

Insulin resistance,Lipodystrophies (Lawrence-Seip syndrome)

Front 22

ACANTHOSIS NIGRICANS Type A Syndrome:

Back 22

severe acanthosis nigricans, hirsutism, clitoromegaly, and masculine habitus

Front 23

ACANTHOSIS NIGRICANS Type B Syndrome: occurs when and in whom, what ctd assoc?

Back 23

AN after teenage years with less extensive involvement, with often underlying SLE

Hint 23

None

Front 24

ACANTHOSIS NIGRICANS Drugs:

Back 24

testosterone, nicotinic acid, diethylstilbestrol, oral contraceptives, triazinate, glucocorticoids,

Front 25

LIPODYSTROPHY partial Begins on

Back 25

face, spreads downward, stopping at any level

Front 26

LIPODYSTROPHY partial onset, sex

Back 26

female, and usually begins before age 15

Hint 26

None

Front 27

LIPODYSTROPHY partial Laboratory

Back 27

Hypertriglyceridemia Decreased serum complement (C3), Increased C3 nephritic factor (immunoglobulin that binds Factor H, an inhibitor of C3,)

Front 28

Generalized Lipodystrophy Congenital

Back 28

(Seip-Lawrence Syndrome)

Front 29

Generalized Lipodystrophy Acquired

Back 29

(Berardinelli-Seip Syndrome)

Front 30

Generalized Lipodystrophy Mental retardation?

Back 30

common

Front 31

Generalized Lipodystrophy assoc skin condition?

Back 31

Eruptive xanthomas may appear

Front 32

Sweets labs normal vs malignancy assoc

Back 32

Malignancy-associated Sweet’s: anemia, normal or low neutrophil count and abnormal platelet count

Front 33

Sweets Can be associated with intestinal infection with

Back 33

yersinia enterocolitica

Front 34

Sweets Associated Diseases

Back 34

AML; lesions may precede diagnosis of leukemia;

Front 35

Sweets how many lesions suggest malignancy?

Back 35

20

Front 36

EAC associations

Back 36

malignancy, dermatophyte

Front 37

EED positiive skin test to?

Back 37

Markedly positive skin tests to intradermally injected streptokinase-streptodornase

Front 38

EED lab

Back 38

IgA (mainly) or IgG or IgM monoclonal gammopathies or even myeloma

Front 39

EN 70% have associated _ that may pesist for years?

Back 39

arthropathy

Front 40

EN infections:

Back 40

strep, tb yersinia, blasto, viruses

Front 41

Sarcoidosis Remember, hilar adenopathy and erythema nodosum also present in

Back 41

lymphoma, tb, streptococcal infectionsand fungal infections

Front 42

Mastocytosis provoked by

Back 42

alcohol, aspirin, narcotics, contrast agents (iodinated), insect stings, exercise, or infections

Front 43

Mastocytosis Most common skin manifestation in children and adults

Back 43

Urticaria pigmentosa

Front 44

Mastocytosis Obtain 24 hour urine for

Back 44

5-hydroxyindoleacetic acid (5-HIAA) and urinary metanephrines

Front 45

Mastocytosis Mast cell leukemia: survival

Back 45

less than 6 months

Front 46

CUTANEOUS SARCOIDOSIS skin lesions in ?%

Back 46

25

Front 47

CUTANEOUS SARCOIDOSIS Nonspecific lesion:

Back 47

erythema nodosum, alopecia, erythroderma, subcutaneous nodules, erythemamultiforme, itching ichthyotic dryness, dystrophic calcifications, and verrucous outgrowths

Front 48

CUTANEOUS SARCOIDOSIS subq variant

Back 48

Darier-roussy sarcoidosis

Front 49

CUTANEOUS SARCOIDOSIS labs

Back 49

hyper CA (vitD3 overproduced), ACE level

Front 50

CUTANEOUS SARCOIDOSIS Intradermal injection of homogenized tissue from sarcoidosis patient

Back 50

Kveim Test

Front 51

CUTANEOUS SARCOIDOSIS Treatment

Back 51

steroids, antimalrials, immunosuppressive

Front 52

EPS Patients with

Back 52

Down’s Syndrome, heritable connective tissue disorders (Ehlers-Danlos Type IV, osteogenesisimperfecta,Marfan’s Syndrome, Rothmund-Thomson, scleroderma, and acrogeria)

Front 53

EPS drug inducer

Back 53

imperfecta,Marfan’s Syndrome, Rothmund-Thomson, scleroderma, and acrogeria)

Front 54

EPS location

Back 54

Nape and sides of neck, upper extremities

Front 55

Pregnancy hair changes

Back 55

Increased anagen, decreased telogenTelogen effluvium: 1-5 mos. Post-partum, stopping within 15 mos.;

Front 56

Pregnancy chadwick sign

Back 56

blue vagina

Front 57

Pregnancy goodell sign

Back 57

blue cervix

Front 58

Pregnancy Tumors

Back 58

granuloma gravidarum, glomagiomas, leiomyomas, desmoid (rectus adb) NF

Front 59

Pregnancy Melanoma prognosis

Back 59

diagnosis during pregnancy associated with thicker tumors; same prognosis

Front 60

Pregnancy Pemphigoid Gestationis

Back 60

BP

Front 61

Cholestasis of Pregnancy trimester

Back 61

3

Front 62

Cholestasis of Pregnancy 50% associated with

Back 62

uti

Front 63

Cholestasis of Pregnancy perinatal risk

Back 63

low vit K- bleeding

Front 64

Cholestasis of Pregnancy Fetus:

Back 64

premature labor (common), fetal distress, perinatal death

Front 65

Cholestasis of Pregnancy Treatment

Back 65

CholestyramineUrsodeoxycholic acid

Front 66

impetigo herpetiformis” aka

Back 66

Pustular Psoriasis of Pregnancy

Front 67

impetigo herpetiformis” trimester

Back 67

Late 1st trimester to 3rd trimester

Front 68

impetigo herpetiformis” Fetus at risk for

Back 68

placental insufficiency

Front 69

impetigo herpetiformis” lab

Back 69

hypoCA, leukocytosis

Front 70

pruritus association of malignancy and generalized itching is rare, with the exceptions of

Back 70

hodgkins, PCV

Front 71

SCLEREDEMA Skin involvement may be preceded by

Back 71

prodrome of low-grade fever, malaise, myalgia, arthralgia

Front 72

SCLEREDEMA types

Back 72

I-post infection (strep get ASO) II monoclonal gammopathy 3-diabetes

Front 73

Apocrine Glands Stain with

Back 73

GCDFP-15keratin AE1 (stains ducts), CAM 5.2, EMA

Front 74

Eccrine Glands Stain with

Back 74

S100, CEA, CAM 5.2

Front 75

Sebaceous Glands on eyelid

Back 75

Meibomian and Wolf

Front 76

Sebaceous Glands (on penis),

Back 76

Tyson

Front 77

Sebaceous Glands nipple

Back 77

Montgomery

Front 78

Hair Follicle Infundibulum = portion above insertion of

Back 78

sebaceous duct;

Front 79

Hair Follicle Isthmus = portion between insertions of

Back 79

sebaceous duct and arrector pili; trichilemmal keratinization;

Front 80

Hair Follicle dsg in inner root sheath and innermost part outer root sheath

Back 80

dsg1

Front 81

Hair Follicle Trichilemmal carcinoma stains with

Back 81

keratin 17 and c-erb-b2

Front 82

Hair Follicle Proliferating trichilemmal cyst stains with

Back 82

cytokeratin 7

Front 83

STAINS Nerve fibers black

Back 83

Bodian

Front 84

STAINS DNA magenta

Back 84

Feulgen

Front 85

STAINS Fontana Masson

Back 85

Melanin

Front 86

STAINS Foote’s or Snook’s

Back 86

Reticulin fibers black

Front 87

STAINS Mast cell granules purple

Back 87

Giemsa

Front 88

STAINS Leishmania

Back 88

Giemsa

Front 89

STAINS Mast cell granules red

Back 89

Leder

Front 90

STAINS Masson Trichrome

Back 90

Collagen blue/green, muscle/nerve/keratin red

Front 91

STAINS Methyl-green Pyronin

Back 91

RNA pink, DNA green

Front 92

STAINS Perls (Prussian Blue)

Back 92

Iron/hemosiderin bright blue

Front 93

STAINS PTAH (Phosphotungstic Acid Hematoxylin)

Back 93

Stains fibrin

Front 94

STAINS PTAH stains inclusions in

Back 94

infantile digital fibromatosis

Front 95

STAINS Amyloid

Back 95

congo red, crystal violet, thioflavin T, orcein-giemse

Front 96

STAINS Calcium

Back 96

Von Kossa (blue-black)• Alizarin red (red)

Front 97

STAINS Elastic Tissue

Back 97

verhoeff von giesen, gomoris aldehyde fuchsin

Front 98

STAINS Osmium tetroxide

Back 98

fat

Front 99

STAINS Sudan black

Back 99

fat

Front 100

STAINS Oil red O

Back 100

fat

Front 101

STAINS Scarlet red

Back 101

fat

Front 102

STAINS Mucin

Back 102

Colloidal iron (blue)• Mucicarmine (pink)

Front 103

STAINS Ochronosis

Back 103

Cresyl violet or methylene blue stains the pigment black

Front 104

STAINS Spirochetes

Back 104

Silver stains like Warthin Starry or Dieterle or Steiner

Front 105

Darier’s Disease (Keratosis Follicularis) path

Back 105

Column of parakeratosis above a focus of acantholytic dyskeratosis (corps ronds and grains)

Front 106

Grovers path

Back 106

dariers, hailey-hailer, spongiotic, PV

Front 107

PP targets

Back 107

Intercellular and linear DEJ antibodies against desmoplakins (250 kDa, 230 kDa bullous pemphigoid antigen1), envoplakin (210 kDa), periplakin (190 kDa), 170 kDa antigen, PV Ag (130 kDa)

Front 108

Squamous Cell Carcinoma, Adenoid Type Also called

Back 108

acantholytic SCC

Front 109

Warty Dyskeratoma Can look exactly like

Back 109

Darier’s,

Front 110

Acrospiroma 3 variants

Back 110

hidroacanthoma simplex, poroma (connected), Hidradenoma (not connected)

Front 111

Apocrine Hidrocystoma path

Back 111

The cyst lining shows apocrine-type decapitation secretionouter myeepithelial, inner columnar epi cells

Front 112

Bronchogenic Cystpath

Back 112

pseudostrat, goblet cells

Front 113

Eccrine Hidradenoma, Eccrine Acrospiroma, Nodular Hidradenoma (has ducts) path

Back 113

Biphasic cellular population: round cells with eosinophilic cytoplasm and oval vesicular nucleus or cells withclear cytoplasm with small dark eccentrically located nucleus

Front 114

Cylindroma origin

Back 114

apocrine

Front 115

Brooke-Spiegler syndrome:

Back 115

multiple trichoepitheliomas, cylindromas, spiradenomas

Front 116

Hidradenoma Papilliferum path, location

Back 116

Papillated projections into cystic spaces, decapitation secretionVulvar area

Front 117

Morpheaform Basal Cell Carcinoma (BCC) stains BCCs diffusely

Back 117

Bcl-2

Front 118

Nevus Sebaceus of Jadassohn tumors

Back 118

trichoblastoma thought to be the most common, followed byRubinstein-Taybi, Gardner’s (cyst-like pilomatricomas), Turner’s,

Front 119

Multiple pilomatricomas seen in

Back 119

Rubinstein-Taybi, Gardner’s (cyst-like pilomatricomas), Turner’s,sarcoidosis, sternal cleft and coagulation defects, myotonic dystrophy (Steinert’s)

Front 120

3 keys to immunodef in kids

Back 120

1. FTT 2. Diarrhea, 3. Pneumonia. If no to all three no immunodef.

Front 121

Bleeding diathesis imunodef

Back 121

WA

Front 122

thrush after 2?

Back 122

very worrisome..HIV

Front 123

Ataxia telangectasia gene/function

Back 123

ATM / PI3k

Front 124

Ataxia telangectasia inherited

Back 124

AR

Front 125

Ataxia telangectasia associated cancers

Back 125

breast, lymphoma

Front 126

Ataxia telangectasia screening breast ca?

Back 126

dont use mammogram- DNA repair defect

Front 127

Ataxia telangectasia telangectasias where?

Back 127

bulbar first

Front 128

Ataxia telangectasia besides ataxia, telang. what other cut findings?

Back 128

progeroid (90%), freckling, GRANULOMAS

Front 129

Ataxia telangectasia labs

Back 129

elevated Alpha-FP, CEA

Front 130

Ataxia telangectasia pneumonic?

Back 130

Ataxia A-T low AGE 2....AGE for decr A,G,E

Front 131

Ataxia telangectasia imaging if needed use what

Back 131

MRI not CT

Front 132

CGD enzyme

Back 132

NADPH Oxidase

Front 133

CGD inheritence

Back 133

AR most

Front 134

CGD May present mimicking what in kids

Back 134

foll occlusion triad

Front 135

CGD osteomyelitis. what organism

Back 135

serratia

Front 136

Chronic mucocut candidiasis 4 skin findings

Back 136

nails thick, paronychia, thrush, plaques/patches periorificially

Front 137

Chronic mucocut candidiasis dz assoc with CMC

Back 137

KID syndrome, multiple carbox def, zn def, EEC

Front 138

Cartilage Hair Hypoplasia enzyme

Back 138

RNA RNP endonuclease

Front 139

Cartilage Hair Hypoplasia presents as

Back 139

short limbed dwarfism, sparse hair, doughy skin

Front 140

Cartilage Hair Hypoplasia people

Back 140

amish, finnish

Front 141

Cartilage Hair Hypoplasia very susceptible to

Back 141

varicella

Front 142

Cartilage Hair Hypoplasia increased risk of

Back 142

NHL, BCC

Front 143

Leukocyte adhesion def. TYPE 1 gene

Back 143

CD18 encoding beta2integrin

Front 144

Leukocyte adhesion def. TYPE 1 blocks what, like what drug?

Back 144

LFA-ICAM like efalizumab

Front 145

Leukocyte adhesion def. TYPE 1 perinatally

Back 145

blocks umbilical separation

Front 146

Leukocyte adhesion def. TYPE 1 TYPE 2 enzyme

Back 146

GDP fucose synthesis

Front 147

Bruton's inheritenc?`

Back 147

xlr 90%

Front 148

Bruton's gene

Back 148

btk

Front 149

Bruton's incr suscepti to?

Back 149

HBV, enterovirus

Front 150

Bruton's skin

Back 150

eczema

Front 151

Bruton's wierd viral reaction

Back 151

dermatomyositis from echovirus

Front 152

Hyper IgM inheritence & gene

Back 152

XLR, CD40 ligand

Front 153

Hyper IgM Zonana?

Back 153

ED + hyperIgM

Front 154

Hyper IgM skin

Back 154

oral ulcers, warts

Front 155

CVID what type of GI infection prevails?

Back 155

giardia

Front 156

IgA Deficiency 50% have what

Back 156

anti IgA ab

Front 157

HyperIgD gene/enzyme

Back 157

mevalonate kinase

Front 158

HyperIgD presents like what other illness?

Back 158

JRA - periodic fever, arthralgias

Front 159

Duncans aka

Back 159

Ilinked lymphoproliferative dz

Front 160

Duncans gene

Back 160

SH2 DIA

Front 161

Duncans pathogenesis (problem)

Back 161

humoral and T cell response to EBV

Front 162

Duncans death from?

Back 162

70% B cell lymphoma

Front 163

Hyper IgE aka

Back 163

job Buckley

Front 164

Hyper IgE skin

Back 164

eczema (severe) corase facial features, retained primary teeth, recurrent infections

Front 165

Hyper IgE IgE level in HyperIgE

Back 165

>5-10,000

Front 166

Wiskott-Aldrich gene/inheritence

Back 166

xlr, WASP

Front 167

Wiskott-Aldrich WASP function

Back 167

ASSEMBLY FOR VESCLE TRANSPORT, PLATELET FORMATION

Front 168

Wiskott-Aldrich 3 CLINICAL FINDINGS

Back 168

bleeding diathesis (only immunodef with bloody diarrhea), atopic dermatitis, recurrent infections

Front 169

Wiskott-Aldrich 26% develop

Back 169

lymphomas

Front 170

DiGeorge Sx mutation

Back 170

TBX1

Front 171

DiGeorge Sx kids present with

Back 171

neonatal tetany

Front 172

DiGeorge Sx pneumonic

Back 172

CATCH22 Cardiac, Abnormal facies, Thymic hypoplasia Cleft palate Hypocalcemia

Front 173

ChediakHigashi gene

Back 173

LYST

Front 174

ChediakHigashi die from

Back 174

90% lymphoproliferative

Front 175

ChediakHigashi lymphoproliferative dz triggered by EBV. dont confuse with

Back 175

Duncans

Front 176

ChediakHigashi tx with __ corrects microtubule function but does not prevent accelerated phase

Back 176

ascorbic acid

Front 177

HYPERLIPOPROTEINEMIAS pneumonic

Back 177

1(5)432 was a CVIL year

Front 178

HYPERLIPOPROTEINEMIAS type I enzyme

Back 178

apoCII

Front 179

HYPERLIPOPROTEINEMIAS Tuberous Xanthoma systemic findings?

Back 179

biliary cirrhosis

Front 180

HYPERLIPOPROTEINEMIAS Eruptive Xanthoma drugs causing

Back 180

estrogen therapy, corticosteroids, isotretinoin, acitretin

Front 181

Plane Xanthoma Frequently associated with biliary

Back 181

cirrhosis, biliary atresia, myeloma, HDL-deficiency, monoclonal gammopathy, lymphoma, leukemia, serum lipoprotein deficiency, xanthomas following erythroderma, RA, Acquired C1 esterase deficiency

Front 182

Palmar Xanthoma Xanthoma striata palmaris: diagnostic of ?

Back 182

type III dysbetalipoprotinemia (broad beta disease)

Front 183

Supplementation required in rubeola (200,000

Back 183

vit A

Front 184

Vitamin D Deficiency: only skin manifestation

Back 184

alopecia

Front 185

Vitamin B1 (Thiamine) Deficiency only skin manifestation

Back 185

Edema (beri beri)

Front 186

Vitamin B2 (Riboflavin) Deficiency aka

Back 186

Oral-ocular-genital syndrome

Front 187

Vitamin B12 Deficiency sx

Back 187

Glossitis, Hyperpigmentation resembles Addison’s Disease,

Front 188

Vitamin C Deficiency (Scurvy) sx

Back 188

Perifollicular petechiae, Subungual, subconjunctival, intramuscular, and intraarticular hemorrhage

Front 189

Hartnup disease what is it

Back 189

(impaired absorption of tryptophan)

Front 190

Hartnup disease drugs causing

Back 190

INH, azathioprine, 5-FU

Front 191

Biotin Deficiency what enzyme deficiencies?

Back 191

Multiple carboxylase deficiency• Holocarboxylase synthetase deficiency

Front 192

Zn deficiency labs

Back 192

low AP (zn dependent), low Zn

Front 193

Essential Fatty Acid Deficiency Similar dermatitis to that of

Back 193

zinc and biotin deficiency

Front 194

Essential Fatty Acid Deficiency skin

Back 194

Widespread erythema and intertriginous weeping eruption• Hair becomes lighter in color

Front 195

Essential Fatty Acid Deficiency labs

Back 195

• Ratio of eicosatrienoic acid to arachidonic more than 0.4 diagnostic of EFA deficiency

Front 196

Iron Deficiency skin

Back 196

Koilonychia, glossitis, angular cheilitis, pruritus, and telogen effluvium

Front 197

Iron Deficiency Plummer-Vinson:

Back 197

"microcytic anemia, dysphagia, and glossitis seen nearly entirely in middle-aged women;

Front 198

Selenium Deficiency hair, nails

Back 198

Hypopigmentation of the skin and hair• Leukonychia and Terry’s nails occasionally

Front 199

Lycopenemia

Back 199

Excessive ingestion of red foods like tomatoes, beets, chili beans, and various fruits leads to reddish

Front 200

Necrobiosis Lipoidica % diabetics

Back 200

0.30%

Front 201

Histiocytosis X spectrum

Back 201

Letterrer-Siwe: baby, mastoid osteolysis (only site), fatal, cut 80%; HSC: early childhood, DI, cut 30% (cranium osteolysis); EG benign; HP (CSHR), babies but heals

Front 202

Pagetoid Reticulosis aka

Back 202

Woringer-Kolopp if localized

Front 203

MF Prognosis

Back 203

Involvement of 10% or less with patch disease: median survival of 12 years• Tumors, erythroderma, or node involvement: median survival 2-3 years

Front 204

Pyo Gangrenosum 50% have associated disease, most commonly

Back 204

IBD

Front 205

Pyo Gangrenosum other assoc dzs

Back 205

leukemia, myeloma, monoclonal gammopathy (IgA), polycythemia, chronic active hepatitis,HCV, HIV, SLE, pregnancy, and Takayasu’s Arteritis

Front 206

PAPA

Back 206

pyogenic arthritis, pyoderma gangrenosum, severe cystic acne

Front 207

Pyo Gangrenosum what kids predisposed?

Back 207

Children with congenital deficiency of leukocyte-adherence glycoproteins

Front 208

Trichilemmoma Proliferation of

Back 208

outer root sheath

Front 209

Rasmussen’s syndrome: multiple trichoepitheliomas, cylindromas, and milia

Back 209

multiple trichoepitheliomas, cylindromas, and milia

Front 210

Rombo syndrome:

Back 210

multiple trichoepitheliomas, milia, vermiculate atrophy, BCC, peripheral vasodilation

Front 211

Herpes gestationis can be indistinguishable from BP on biopsy but on DIF

Back 211

linear C3 not so much IgG

Front 212

Cicatricial Pemphigoid (CP) ab

Back 212

Anti-epiligrin

Front 213

Porphyria Cutanea Tarda (PCT) path

Back 213

Festooning of dermal papillae• “Caterpillar bodies”

Front 214

Porphyria Cutanea Tarda (PCT) dif

Back 214

DIF with IgG, IgM, IgA, C3 at DEJ and around vessels

Front 215

Juvenile colloid milium is histochemically indistinguishable from

Back 215

amyloid

Front 216

sx with macular and lichen amyloid

Back 216

men iib

Front 217

Papular Mucinosis (lichen myxedematosus) ka scleromyxedema on path

Back 217

In scleromyxedema variant, fibroblasts are numerous (increased in number)More cellular than pretibial myxedema

Front 218

Pretibial Myxedema Associated with

Back 218

Grave’s disease and thyroid acropachy

Front 219

Scleromyxedema Associated with paraproteinemia, generally

Back 219

IgG lambda

Front 220

Fixed Drug Eruption versus PLEVA

Back 220

PLEVA has parakeratosis and lacks the eosinophils of either fixed drug or LyP

Front 221

Minocycline-induced Pigmentation 3 types:

Back 221

blue-black in scars on the face, blue-gray on legs, muddy-brown on sun-exposed areas;

Front 222

Minocycline-induced Pigmentation The blue-black color in scars on the face stains like

Back 222

hemosiderin (Perls-positive)

Front 223

Minocycline-induced Pigmentation Blue-gray on legs stains like

Back 223

iron and melanin (stains with Perls and Fontana Masson)

Front 224

Minocycline-induced Pigmentation Muddy-brown color on sun-exposed areas shows

Back 224

melanin-fontana masson

Front 225

Alpha-1-Antitrypsin Deficiency Panniculitis type of panniculitis, and findings on path

Back 225

lobular, with ft necrosis

Front 226

Erythema Induratum (Nodular Vasculitis) type of paniculitis

Back 226

lobular

Front 227

Erythema Induratum (Nodular Vasculitis) characteristic feature

Back 227

Vasculitis (often at dermal/SC junction) with endothelial swelling

Front 228

Lipodermatosclerosis aka

Back 228

Lipomembranous Panniculitis)

Front 229

Pancreatic Panniculitis path

Back 229

Lobular panniculitis, fat necrosis with “ghost cells” having no nuclei

Front 230

Polyarteritis Nodosa path

Back 230

Septal panniculitis with medium-sized vessel vasculitis• Inflammation tightly localized around vessel

Front 231

Atrophie Blanche aka

Back 231

(Segmental Hyalinizing Vasculitis)

Front 232

Atrophie Blanche path

Back 232

In fully established plaques there is epidermal atrophy with scleroderma-like scarring

Front 233

afx staining

Back 233

cd68 alpha 1 antitrypsin, muscle specific actin

Front 234

DF staining

Back 234

fctor XIIIa, stromeolysn +

Front 235

DFSP cd34+, what else is

Back 235

giant cell fibroblastoma

Front 236

DFSP come from what translocation?

Back 236

translocation results in the fusion of two genes:collagen type I alpha 1(COL1A1) and platelet-derived growth factor B-chain (PDGFB)

Front 237

Epithelioid Sarcoma locations

Back 237

forearms, young adults

Front 238

Epithelioid Sarcoma stains

Back 238

vimentin +, low mol wt cytokeratin +

Front 239

Gian cell epulis exacyly like what but more superficial

Back 239

iant cell tumor tendon sheath

Front 240

giant cell tumor tendon sheath unique appearing cells

Back 240

osteoclast like

Front 241

keloids, what syndrmes get lotsof keloids

Back 241

Rubinstein-Taybi, Noonan’s, and Turner’s syndromes

Front 242

clinical and gene Birt-Hogg-Dube

Back 242

Triad of fibrofolliculomas, skin tags, and trichodiscomas…folliculin

Front 243

clinical and gene Cowdens

Back 243

Multiple trichilemmomas, sclerotic fibromas (storiform collagenoma), acral keratoses, oral fibromas• Increased risk of breast/thyroid cancer. PTEN

Front 244

clinical and gene Ichthyosis Vulgaris

Back 244

profillagrin

Front 245

Multiple JXGs are associated with

Back 245

NF1, CML

Front 246

reticulohistiocytosis clinical sign by nail

Back 246

“coral bead sign”,

Front 247

Coccidioidomycosis microscopic

Back 247

Spherules (which contain and can collapse to release endospores Õ 10-80 microns)

Front 248

HSV aka for cowdrsy A bodies

Back 248

lipschutz

Front 249

Leishmaniasis vs histo on path

Back 249

histo has tiny halo, no kinetoplast

Front 250

lichen striatus path

Back 250

Low power shows a nearly empty dermis, but deep dermis shows a dense infiltrate around the adnexalstructures Õ very unique to this entity

Front 251

Perniosis similar to what on path

Back 251

pmle

Front 252

Pityriasis Lichenoides et Varioliformis Acuta (PLEVA) path

Back 252

parakeratosis, necrotic keratinocytes, papillary edema, lymphocytes, RBCs

Front 253

Pityriasis Lichenoides et Varioliformis Acuta (PLEVA) versus LyP, versus EM

Back 253

lyp has eosinophils. EM doesn’t have parakeratosis

Front 254

PMLE path

Back 254

spongiosis, lymphocytes, ppillary edema, deeper infiltrate than SCLE

Front 255

PMLE

Front 256

Leukemia Cutis most commo type

Back 256

AML

Front 257

Leukemia Cutis Neoplastic cells stain positive for

Back 257

Leder, lysozyme, myeloperoxidase

Front 258

Lymphoma Cutis path and staining

Back 258

cd20+, bottom heavy, epidermis spared

Front 259

LyP path

Back 259

wedge shaped, PLEVA like, more atypical cells, eos and neuts

Front 260

LyP types

Back 260

A: Type A: CD30-positive; B: MF type with sezary cells

Front 261

Mantle Cell Lymphoma translocations

Back 261

bcl-1 (Cyclin D1) positive [t(11;14) translocation involving bcl-1 and the immunoglobulinheavy chain gene]

Front 262

Mantle Cell Lymphoma versus CLL staining

Back 262

Lack CD 23 (unlike CLL)

Front 263

Mantle Cell Lymphoma chain restriction

Back 263

Often has lambda light chain restriction

Front 264

MF staining

Back 264

CD4+ cells in the epidermis that have often lost CD5 and CD7

Front 265

Subcutanous Panniculitis-like T-cell Lymphoma die how?

Back 265

can have fatal hemophagocytic syndrome1. Alpha-beta T-cells that are CD 8+, more indolent clinically

Front 266

Subcutanous Panniculitis-like T-cell Lymphoma two groups

Back 266

1. Alpha-beta T-cells that are CD 8+, more indolent clinically2. Gamma-delta T-cells that are CD 56+, more aggressive (fatal) with systemic hemophagocytosis

Front 267

CD10

Back 267

follicular B cell lymphoma

Front 268

CD16

Back 268

NK cells

Front 269

CD 19,20

Back 269

B cells

Front 270

CD 23

Back 270

CLL (- Mantle cell)

Front 271

CD 30

Back 271

anaplastic large cell, LyP, Hodgkins

Front 272

CD 57

Back 272

T cells with NK activity

Front 273

CD 138

Back 273

plsma cells

Front 274

BCL-1

Back 274

mntle cell

Front 275

bcl-2

Back 275

NODAL follicular center cell (primary is bcl2 negative), BCCs

Front 276

bcl-6

Back 276

follicular cell lymphoma

Front 277

stains desmoplastic melanoma

Back 277

s100+, Mart 1 negative

Front 278

spitz versus reed

Back 278

reed is in epidermis,, spitz has no epidermal involvement

Front 279

leiomyoma gene defect

Back 279

fumarate hydratase

Front 280

leiomyoma stains

Back 280

desmin, SMA

Front 281

celular neurothekeoma s100?

Back 281

negative

Front 282

granular cell tumor

Back 282

s100+, vimentin+, NSE +

Front 283

traumatic neuroma path

Back 283

acral, haphazard nerve fascicles

Front 284

Breast metastatic stains

Back 284

cea+ CK7 +

Front 285

Pagets of the breast stains

Back 285

CEA+, EMA+, CAM 5.2+ Alcian blue pH 2.5

Front 286

Angiosarcoma em

Back 286

weibel-Palade

Front 287

bacilary angiomatosis path, stain for organsms

Back 287

blue clouds, Warthin-Starry

Front 288

Intravascular Papillary Endothelial Hyperplasia aka

Back 288

Massons

Front 289

Intravascular Papillary Endothelial Hyperplasia path

Back 289

Thrombosed vessel (circular space with pink fibrin within) with papillated fronds projecting into the center;the fronds are lined by a single layer of endothelial cells

Front 290

Intravascular Papillary Endothelial Hyperplasia

Back 290

the fronds are lined by a single layer of endothelial cells

Front 291

Kaposi's staining

Back 291

Spindle cells are CD34-positive and focally positive for CD31; Ulex – positive; Factor VIII positive

Front 292

Chloroma cancer

Back 292

acute grnulocytic leukemia

Front 293

Chloroma green color from?

Back 293

myeloperoxidase

Front 294

Chloroma stain

Back 294

chloracetate esterase-positive

Front 295

Merkel stains

Back 295

ck20, NSE

Front 296

Merkel vs metastatic oat cell

Back 296

negative ck20

Front 297

sclerotic fibroma syndromes

Back 297

cowdens, gardners

Front 298

pseudoepitheliomatous hyperplasia don’t forget what..besides infections

Back 298

bromoderma/halogenoderma

Front 299

Asteroid Body

Back 299

sporotrichosis OR• Stellate inclusions seen in sarcoid, berylliosis

Front 300

Comma-shaped Body

Back 300

em: benign cephalic histiocytosis

Front 301

donovan body

Back 301

Granuloma inguinale

Front 302

Dutcher Body

Back 302

Pseudo”-nuclear inclusions secondary to collections of immunoglobulin in the cytoplasm that push into thenucleus of plasma cells

Front 303

Guarnieri Body

Back 303

smallpox

Front 304

Negri Body

Back 304

rabies

Front 305

Russell Body

Back 305

• Inclusions secondary to collections of immunoglobulin in the cytoplasm of plasma cells• Seen in rhinoscleroma, granuloma inguinale, syphilis

Front 306

Russell Body

Back 306

• Seen in rhinoscleroma, granuloma inguinale, syphilis

Front 307

Zebra Body

Back 307

Seen on electron microscopy in mucopolysaccharidoses

Front 308

AML stains

Back 308

CD43 myeloperoxidase CD15

Front 309

NXG v XG

Back 309

NXG in fat necrosis larger foamy cells

Front 310

Mixed tumor skin aka

Back 310

pleomorphic adenoma (in parotid gland)

Front 311

matt how long is the program?

Back 311

3 years

Front 312

Pityriasis Versicolor (Tinea Versicolor) most common cause of TV),

Back 312

M. globosa (

Front 313

Pityriasis Versicolor (Tinea Versicolor) Woods lamp

Back 313

(+) pale yellow fluorescence

Front 314

Tinea Nigra Palmaris organism

Back 314

Phaeoannellomyces werneckii

Front 315

White Piedra Trichosporon beigelii, new nomenclature:

Back 315

Trichosporon ovoides and T. inkin

Front 316

White Piedra Trichosporanosis organism

Back 316

Trichosporon asahii

Front 317

Ectothrix organsism

Back 317

M. canis, M. audouinii, M. distortum, M. ferrugineum, and sometimes M.

Front 318

Endothrix “Black Dot Ringworm” organisms

Back 318

T. rubrum, T. gourvilli, T. yaounde, T. tonsurans, T. schoenleinii, T. soudanense, T. violaceum

Front 319

Kerion Most frequently due to

Back 319

M. canis, T. tonsurans, T. verrucosum, T. mentagrophytes

Front 320

Tinea Corporis the most frequently recovered organisms

Back 320

T. rubrum, T. mentagrophytes, M. canis, T. tonsurans

Front 321

Majocchi’s Granuloma associated with what organism

Back 321

T. rubrum,

Front 322

Tinea Barbae Inflammatory:

Back 322

T. mentagrophytes, T. verrucosum

Front 323

Tinea Barbae Abscess:

Back 323

M. canis

Front 324

Tinea Barbae Verrucous granulomatosis:

Back 324

E. floccosum

Front 325

Tinea Cruris organisms

Back 325

E. floccosum, T. rubrum, T. mentagrophytes

Front 326

Tinea Faciei organisms

Back 326

T. rubrum, T. mentagrophytes, T. concentricum, M. canis

Front 327

Tinea Manuum organisms

Back 327

T. rubrum, T. mentagrophytes, E. floccosum

Front 328

Tinea Pedis Moccasin type:

Back 328

E. floccosum, T. rubrum

Front 329

Tinea Pedis Vesicular type:

Back 329

T. mentagrophytes

Front 330

Distal Lateral Subungual Onychomycosis

Back 330

T. rubrum

Front 331

Proximal Subungual Onychomycosis

Back 331

T. rubum

Front 332

Proximal White Subungual Onychomycosis an AIDS markjer (not superficial white)..what is the organism?

Back 332

T. rubrum

Front 333

White Superficial Onychomycosis

Back 333

T. mentagrophytes,

Front 334

colony morphology E. floccosum

Back 334

khaki-colored colony,

Front 335

colony morphology M. audouinii

Back 335

mouse fur - grey or tan

Front 336

colony morphology M. canis

Back 336

white fluffy, fur-like colony with yellow periphery and feathery border. Pee in the snow

Front 337

colony morphology M. gallinae

Back 337

white colony becoming pink with age. Reverse strawberry

Front 338

colony morphology M. gypseum

Back 338

powdery colony,

Front 339

wierd fungal stuff (+) wedge shaped areas in hair shaft

Back 339

T. mentagrophytes

Front 340

wierd fungal stuff makes pigment on cornmeal agar

Back 340

(+) T. rubrum, (–) T. mentagrophytes

Front 341

wierd fungal stuff Niacin

Back 341

T. equinum

Front 342

wierd fungal stuff Histidine

Back 342

T. megninii

Front 343

wierd fungal stuff Inositol and thiamine

Back 343

T. verrucosum

Front 344

wierd fungal stuff Urease Test

Back 344

(+) red - pink T. mentagrophytes

Front 345

colony morphology T. mentagrophytes

Back 345

fluffy white

Front 346

colony morphology T. rubrum

Back 346

reverse nondiffusible red,

Front 347

colony morphology T. concentricum

Back 347

white, waxy colony turns amber or coral red and deeply folded, cerebriform

Front 348

colony morphology T. violaceum

Back 348

heaped purple colony;

Front 349

Scytalidium dimidiatum causes?

Back 349

Dematiaceous organism causing dermatomycoses of the soles and toe webs, paronychia, and

Front 350

SUBCUTANEOUS MYCOSIS list them

Back 350

sporo, mycetomas, chromoblasto, lobo,

Front 351

SUBCUTANEOUS MYCOSIS sporo on path

Back 351

cigar bodies”

Front 352

SUBCUTANEOUS MYCOSIS ruke for all eumycetoma and actinomycetoma pellet colors

Back 352

"FAN of Boyd - Red pellets". All starting with FA o rN and boydii are white. Pelletieri is red.

Front 353

SUBCUTANEOUS MYCOSIS common actinomycetoma organism

Back 353

nocardia

Front 354

SUBCUTANEOUS MYCOSIS chromoblastomycosis organisms

Back 354

Fonsecaea pedrosoi (most common), Fonsecaea compacta, Rhinocladeilla aquaspersa, Phialophora verrucosa,

Front 355

SUBCUTANEOUS MYCOSIS chromo path

Back 355

“copper

Front 356

SUBCUTANEOUS MYCOSIS lobo path

Back 356

“chain of coins” or “brass knuckles”

Front 357

dimoprhic fungi causing systemic disease list them

Back 357

histo, blasto, coccidio, paracoccidio, penicilliosis

Front 358

Histoplasmosis Endemic to

Back 358

Ohio,Mississippi,Missouri River Valleys,

Front 359

Histoplasmosis high risk animals

Back 359

bat, bird (especially starling), and chicken droppings

Front 360

Histoplasmosis non specific skin

Back 360

Toxic erythema, erythema multiforme or erythema nodosum

Front 361

Histoplasmosis specicifc skin findings

Back 361

macules, papules, nodules, ulcers (oral and rectal), molluscum like

Front 362

Histoplasmosis runs from assymptomatic to bad bad. Treatment:

Back 362

Itraconazole drug of choice for disseminated disease

Front 363

Histoplasmosis AIDS patients tx:

Back 363

Itraconazole or Amphotericin B followed by itraconazole, ketoconazole or fluconazole

Front 364

Blastomycosis aka

Back 364

Gilchrists

Front 365

Blastomycosis area

Back 365

Ohio and Mississippi River Valley, Great Lakes area,

Front 366

Blastomycosis Gilchrist’s Disease:

Back 366

primary cutaneous blastomycosis;

Front 367

Coccidioidomycosis aka

Back 367

(California Disease, San Joaquin Valley Fever)

Front 368

Coccidioidomycosis non specific skin findings

Back 368

erythema nodosum, erythema multiforme, toxic erythema

Front 369

Coccidioidomycosis like all the dimorphic fungi, how dfo you get it

Back 369

Asymptomatic and self-limited respiratory tract infection is common

Front 370

Paracoccioidomycosis aka

Back 370

Brazilian Blastomycosis, South American Blastomycosis)

Front 371

Paracoccioidomycosis Endemic area:

Back 371

Brazil (80% of reported cases),

Front 372

Pityriasis Versicolor (Tinea Versicolor) most common cause of TV),

Back 372

M. globosa (

Front 373

Pityriasis Versicolor (Tinea Versicolor) Woods lamp

Back 373

(+) pale yellow fluorescence

Front 374

Tinea Nigra Palmaris organism

Back 374

Phaeoannellomyces werneckii

Front 375

White Piedra Trichosporon beigelii, new nomenclature:

Back 375

Trichosporon ovoides and T. inkin

Front 376

White Piedra Trichosporanosis organism

Back 376

Trichosporon asahii

Front 377

Ectothrix organsism

Back 377

M. canis, M. audouinii, M. distortum, M. ferrugineum, and sometimes M.

Front 378

Endothrix “Black Dot Ringworm” organisms

Back 378

T. rubrum, T. gourvilli, T. yaounde, T. tonsurans, T. schoenleinii, T. soudanense, T. violaceum

Front 379

Kerion Most frequently due to

Back 379

M. canis, T. tonsurans, T. verrucosum, T. mentagrophytes

Front 380

Tinea Corporis the most frequently recovered organisms

Back 380

T. rubrum, T. mentagrophytes, M. canis, T. tonsurans

Front 381

Majocchi’s Granuloma associated with what organism

Back 381

T. rubrum,

Front 382

Tinea Barbae Inflammatory:

Back 382

T. mentagrophytes, T. verrucosum

Front 383

Tinea Barbae Abscess:

Back 383

M. canis

Front 384

Tinea Barbae Verrucous granulomatosis:

Back 384

E. floccosum

Front 385

Tinea Cruris organisms

Back 385

E. floccosum, T. rubrum, T. mentagrophytes

Front 386

Tinea Faciei organisms

Back 386

T. rubrum, T. mentagrophytes, T. concentricum, M. canis

Front 387

Tinea Manuum organisms

Back 387

T. rubrum, T. mentagrophytes, E. floccosum

Front 388

Tinea Pedis Moccasin type:

Back 388

E. floccosum, T. rubrum

Front 389

Tinea Pedis Vesicular type:

Back 389

T. mentagrophytes

Front 390

Distal Lateral Subungual Onychomycosis

Back 390

T. rubrum

Front 391

Proximal Subungual Onychomycosis

Back 391

T. rubum

Front 392

Proximal White Subungual Onychomycosis an AIDS markjer (not superficial white)..what is the organism?

Back 392

T. rubrum

Front 393

White Superficial Onychomycosis

Back 393

T. mentagrophytes,

Front 394

colony morphology E. floccosum

Back 394

khaki-colored colony,

Front 395

colony morphology M. audouinii

Back 395

mouse fur - grey or tan

Front 396

colony morphology M. canis

Back 396

white fluffy, fur-like colony with yellow periphery and feathery border. Pee in the snow

Front 397

colony morphology M. gallinae

Back 397

white colony becoming pink with age. Reverse strawberry

Front 398

colony morphology M. gypseum

Back 398

powdery colony,

Front 399

wierd fungal stuff (+) wedge shaped areas in hair shaft

Back 399

T. mentagrophytes

Front 400

wierd fungal stuff makes pigment on cornmeal agar

Back 400

(+) T. rubrum, (–) T. mentagrophytes

Front 401

wierd fungal stuff Niacin

Back 401

T. equinum

Front 402

wierd fungal stuff Histidine

Back 402

T. megninii

Front 403

wierd fungal stuff Inositol and thiamine

Back 403

T. verrucosum

Front 404

wierd fungal stuff Urease Test

Back 404

(+) red - pink T. mentagrophytes

Front 405

colony morphology T. mentagrophytes

Back 405

fluffy white

Front 406

colony morphology T. rubrum

Back 406

reverse nondiffusible red,

Front 407

colony morphology T. concentricum

Back 407

white, waxy colony turns amber or coral red and deeply folded, cerebriform

Front 408

colony morphology T. violaceum

Back 408

heaped purple colony;

Front 409

Scytalidium dimidiatum causes?

Back 409

Dematiaceous organism causing dermatomycoses of the soles and toe webs, paronychia, and

Front 410

SUBCUTANEOUS MYCOSIS list them

Back 410

sporo, mycetomas, chromoblasto, lobo,

Front 411

SUBCUTANEOUS MYCOSIS sporo on path

Back 411

cigar bodies”

Front 412

SUBCUTANEOUS MYCOSIS ruke for all eumycetoma and actinomycetoma pellet colors

Back 412

"FAN of Boyd - Red pellets". All starting with FA o rN and boydii are white. Pelletieri is red.

Front 413

SUBCUTANEOUS MYCOSIS common actinomycetoma organism

Back 413

nocardia

Front 414

SUBCUTANEOUS MYCOSIS chromoblastomycosis organisms

Back 414

Fonsecaea pedrosoi (most common), Fonsecaea compacta, Rhinocladeilla aquaspersa, Phialophora verrucosa,

Front 415

SUBCUTANEOUS MYCOSIS chromo path

Back 415

“copper

Front 416

SUBCUTANEOUS MYCOSIS lobo path

Back 416

“chain of coins” or “brass knuckles”

Front 417

dimoprhic fungi causing systemic disease list them

Back 417

histo, blasto, coccidio, paracoccidio, penicilliosis

Front 418

Histoplasmosis Endemic to

Back 418

Ohio,Mississippi,Missouri River Valleys,

Front 419

Histoplasmosis high risk animals

Back 419

bat, bird (especially starling), and chicken droppings

Front 420

Histoplasmosis non specific skin

Back 420

Toxic erythema, erythema multiforme or erythema nodosum

Front 421

Histoplasmosis specicifc skin findings

Back 421

macules, papules, nodules, ulcers (oral and rectal), molluscum like

Front 422

Histoplasmosis runs from assymptomatic to bad bad. Treatment:

Back 422

Itraconazole drug of choice for disseminated disease

Front 423

Histoplasmosis AIDS patients tx:

Back 423

Itraconazole or Amphotericin B followed by itraconazole, ketoconazole or fluconazole

Front 424

Blastomycosis aka

Back 424

Gilchrists

Front 425

Blastomycosis area

Back 425

Ohio and Mississippi River Valley, Great Lakes area,

Front 426

Blastomycosis Gilchrist’s Disease:

Back 426

primary cutaneous blastomycosis;

Front 427

Coccidioidomycosis aka

Back 427

(California Disease, San Joaquin Valley Fever)

Front 428

Coccidioidomycosis non specific skin findings

Back 428

erythema nodosum, erythema multiforme, toxic erythema

Front 429

Coccidioidomycosis like all the dimorphic fungi, how dfo you get it

Back 429

Asymptomatic and self-limited respiratory tract infection is common

Front 430

Paracoccioidomycosis aka

Back 430

Brazilian Blastomycosis, South American Blastomycosis)

Front 431

Paracoccioidomycosis Endemic area:

Back 431

Brazil (80% of reported cases),

Front 432

Opportunistic pathogenic fungi: list

Back 432

Aspergillosis, zygomycosis, phaeohyphomycosis, cryptococcus,

Front 433

Aspergillosis Toxicity due to ingestion of contaminated food:

Back 433

aflatoxin

Front 434

Aspergillosis besides a fungal ball in the lung, local necrotic cutaneous infections disseminate disease what else does it cause

Back 434

otitis externa

Front 435

Aspergillosis path

Back 435

45 degree angles

Front 436

Aspergillosis most common spp

Back 436

A. fumigatus

Front 437

Zygomycosis aka

Back 437

Mucormycosis, Phycomycosis)

Front 438

Zygomycosis Most commonly:

Back 438

Absidia, Rhizopus, Mucor

Front 439

Zygomycosis purulent material is distinctive…how?

Back 439

Production of black pus

Front 440

Zygomycosis Risk factors:

Back 440

neutropenia, diabetes mellitus, metabolic acidosis, trauma, burns

Front 441

Zygomycosis variant associated with acidotic diabetes;

Back 441

Rinocerebral zygomycosis:

Front 442

Zygomycosis Pulmonary Zygomycosis: aka

Back 442

FUNGOMA

Front 443

Fusarium (Fusariosis) path

Back 443

identical to aspergillus

Front 444

most common fungus in burn pts

Back 444

fusarium (aspergillus is 2nd)

Front 445

Phaeohyphomycosis good stain

Back 445

fontana-masson

Front 446

Phaeohyphomycosis organisms

Back 446

alternaria, curvularia, exophiala, bipolaris, wangiella

Front 447

Cryptococcosis sources

Back 447

aged pigeon droppings and roosting areas, mouldy fruit,

Front 448

Cryptococcosis % AIDS pt with ut findings after getting crypto

Back 448

10-15%

Front 449

candida oropharyngeal spp

Back 449

C. dubliniensis

Front 450

candida mot common spp

Back 450

C. albicans

Front 451

candida paronychia spp

Back 451

parapsilosis

Front 452

candida spp with fluconazole resistance

Back 452

C glabrata

Front 453

Rhinosporidiosis stains red with

Back 453

mucicarmine

Front 454

Protothecosis organisms

Back 454

Prototheca wickerhamii

Front 455

Protothecosis Worldwide habitat:

Back 455

stagnant water

Front 456

Protothecosis causes what is 1/3 of cases

Back 456

olecrenon bursitis

Front 457

Protothecosis path

Back 457

Mature form contains a symmetrical arrangement of endospores = morula,

Front 458

Protothecosis

Back 458

8-20 µm (“soccer ball”)

Front 459

mycology Umbilicated Lesions Seen In

Back 459

crpto, histo, penicilliosis, cocciioidomycosis

Front 460

Actinomycosis spp

Back 460

Actinomyces israelii

Front 461

Actinomycosis Source of infection is “

Back 461

endogenous

Front 462

Actinomycetoma spp

Back 462

Nocardia brasilensis, Actinomadura madurae, A.

Front 463

Actinomycetoma Source of infection is

Back 463

exogenous

Front 464

Anthrax toxins

Back 464

Edema toxin = Edema Factor (EF) + Protective Antigen (PA)

Front 465

Anthrax EF causes gelatinous edema of anthrax skin lesions by

Back 465

increase cAMP levels

Front 466

Anthrax LF causes shock and death in disseminated anthrax via

Back 466

release of tumor necrosis factor-alpha (TNF-a)

Front 467

Anthrax Treatment:

Back 467

bioterrorism: cirpo, doy: conventional…PCN

Front 468

bartonellosis cat scratch spp

Back 468

henselae

Front 469

bartonellosis cat scratch vector

Back 469

cat flea

Front 470

bartonellosis bacillary angiomatosis

Back 470

henselae, quintana

Front 471

bartonellosis trench fever spp

Back 471

quintana

Front 472

bartonellosis trench fever vector

Back 472

pediculus humnus corporis

Front 473

bartonellosis oroya fever/verruga peruana organism

Back 473

bcilliformis

Front 474

bartonellosis oroya fever vector

Back 474

lutzomyia verrucarum

Front 475

bartonellosis almost al bartonellas are tx with ees or doxy. Oroya fever is treated with:

Back 475

CAM (superinfection with salmonella)

Front 476

Borreliosis lyme disease: spp, vector(s),

Back 476

burgdorferi, NE: Ixodes dammini (scapularis?) NW: Ixodes pacificus, EUROPE: I ricinus

Front 477

Borreliosis Relapsing fever: two forms

Back 477

louse, tick

Front 478

Borreliosis louse born relapsing fever. Spp, vector

Back 478

B recurrentis, pediculus humanus

Front 479

Borreliosis tick born relapsing fever. Spp, vectors

Back 479

B duttonii, ornithodoros (soft bodied ticks)

Front 480

botryomycosis organsism

Back 480

S. aureus, P. aeruginosa, E. coli, and Proteus species

Front 481

Ecthyma Gangrenosum color

Back 481

gunmetal grey

Front 482

Erysipeloid grm+ or grm-

Back 482

grm+ rod

Front 483

Glanders organism

Back 483

Burkholderia mallei

Front 484

Pitted Keratolysis organism

Back 484

micrococcus sedentarius

Front 485

Rat-bite Fever (Haverhill Fever) organism

Back 485

Streptobacillus moniliformis

Front 486

Rhinoscleroma organism

Back 486

Klebsiella pneumoniae rhinoscleromatis

Front 487

Rhinoscleroma path

Back 487

Mikulicz cells on histopathology

Front 488

Rhinoscleroma clincial

Back 488

plaques on nares

Front 489

TSS toxin

Back 489

enterotoxins B,C. TSST-1

Front 490

SSSS toxins

Back 490

exfoliative toxins (ET) A,B

Front 491

Bullous impetigo toxins

Back 491

ET A,B like SSSS

Front 492

Scarlet fever enanthem

Back 492

exudative pharyngitis, strawberry tongue

Front 493

Scarlet Fever exanthem

Back 493

“sandpaper” texture, beginning on head and neck, and then

Front 494

Trichomycosis Axillaris organism

Back 494

Corynebacterium tenuis

Front 495

Tularemia Causative Organism:

Back 495

Francisella tularensis

Front 496

Viral Infections DNA viruses

Back 496

herpes, hepadna, adeno, papova (HPV), parvo, pox

Front 497

Viral Infections which DNA virus is ssDNA

Back 497

parvovirus (E infectiosum)

Front 498

Viral Infections what causes handfoot and mouth dz (virus)

Back 498

picornavirus

Front 499

Congenital Cytomegalovirus (CMV) trimester(s) highest risk

Back 499

1,2

Front 500

Hand-Foot-and-Mouth Disease viruses

Back 500

Coxsackievirus A16 or enterovirus 71

Front 501

Herpangina viruses

Back 501

group A coxsackie

Front 502

Herpes Simplex - Treatment Acyclovir moa

Back 502

Guanosine analogue

Front 503

Herpes Simplex - Treatment Famciclovir moa

Back 503

Prodrug of penciclovir; increased bioavailability and longer half-life

Front 504

Herpes Simplex - Treatment Valcyclovir chemical origin

Back 504

L-valine ester of acyclovir with increased bioavailability

Front 505

Herpes Simplex - Treatment valcyclovir TK dependent?

Back 505

yes

Front 506

Herpes Simplex - Treatment valtrex side effects

Back 506

kidney clearance, TTP in some pts

Front 507

Acyclovir-resistant HSV* – Treatment

Back 507

• Foscarnet – directly inhibits viral DNA polymerase (without requiring phosphorylation by TK)

Front 508

Ramsay Hunt Syndrome Caused by VZV infection of the

Back 508

geniculate ganglion

Front 509

Ramsay Hunt Syndrome triad

Back 509

external ear/TM + facial paralysis + tinnitus

Front 510

Verrucous Carcinoma (HPV-associated) 3 kinds

Back 510

Bushke lowenstein, epithelioma cuniculatum, oral florid papillomatosis

Front 511

measles type of virus

Back 511

a paramyxovirus

Front 512

measles prodrome

Back 512

• “3 C’s:” Cough, Coryza, Conjunctivitis

Front 513

parvo B19 three clinic types

Back 513

kids classic, arthropathy/fever/LAD, papular purpuric gloves and socks

Front 514

parvo B19 in sickle cell

Back 514

aplastic crisis

Front 515

parvo B19 highest pregnany risk

Back 515

hydrops fetalis, first half of pregnancy

Front 516

Rubella aka

Back 516

german measles

Front 517

Rubella clincial

Back 517

3 day rash, post auricular LAD

Front 518

blueberry muffin ddx

Back 518

TORCH

Front 519

smallpox incubation

Back 519

12d

Front 520

smallpox prodrome

Back 520

3d with fever, chills etc but some have petechial bathing suit rash

Front 521

smallpox cytoplasmic eosinophillic inclusions on light microscopy);

Back 521

guarnieri's bodies

Front 522

smallpox vaccination complication in atopic pt

Back 522

eczema vaccinatum

Front 523

smallpox vaccination in pregnant woman

Back 523

congenital vaccinia

Front 524

smallpox vaccination generalized vaccinia in?

Back 524

kids with isolated IgM deficiency

Front 525

smallpox versus varicella

Back 525

vzv in difft stages evolution, mild prodrome

Front 526

varicella/chickenpox congenital risk highest in

Back 526

first 20 weeks

Front 527

varicella/chickenpox cong varicella syndrome

Back 527

hypoplastic limbs, ocular and CNS

Front 528

varicella/chickenpox risk in delivery

Back 528

5 days before and 2 days after delivery:

Front 529

varicella/chickenpox tx neonatal varicella

Back 529

VZIG + acyclovir

Front 530

Leprosy organism

Back 530

M leprae

Front 531

Leprosy paucibacilary tx

Back 531

dapsone 100qd x 6 mo, rifamin 600 qd x 6 mo

Front 532

Leprosy multibacilary tx

Back 532

dapsone, rifampin, clofazimine 12 months

Front 533

Leprosy TT cytokines, lesions, nerves,

Back 533

TH1, <3 lesions, anesthetic

Front 534

Leprosy LL cytokines, lesions, nerves

Back 534

TH2, generalized, no loss of sensation

Front 535

Leprosy Type 2 Reaction:

Back 535

erythema nodosum leprosum

Front 536

Leprosy erythema nodosum leprosum clinically

Back 536

nodules on extremities and face

Front 537

Leprosy erythema nodosum leprosum tx

Back 537

thalidomide

Front 538

Atypical Mycobacteria “Rapid growers”

Back 538

M. fortuitum, M. chelonei, M. abscessus

Front 539

M. Marinum tx

Back 539

minocycline

Front 540

TB name of primary cutaneous infection

Back 540

tuberulous chancre

Front 541

TB tuberculosis verrucosa cutis

Back 541

exogenous reinfection (sensitized host with strong immunity)

Front 542

TB lupus vulgaris-what type of infection

Back 542

hematogenou or lymphatic spread from distnt site

Front 543

TB scrofuloderma-type of infectious process

Back 543

direct spread from underlying TB

Front 544

TB tuberculous gumma - type of infectious process and in whom?

Back 544

hematogenous spread in immunosuppressed host

Front 545

TB tuberculosis cutis orificialis - what type of infection

Back 545

autoinoculation from visceral TB.

Front 546

TB TB-multibacillary forms

Back 546

TB chancre (+/-), scrofuloderma, TB gumma, TB cutis orificialis

Front 547

TB TB pauci bacillary forms

Back 547

lupus vulgaris

Front 548

gonorrhea Recurrent cases may be associated with

Back 548

complement deficiencies (especially C5-C8)

Front 549

syphilis Primary: chancre occurs

Back 549

10d-3 mo

Front 550

syphilis how long does secondary last?

Back 550

Lasts 4 to 12 weeks

Front 551

syphilis Latent timing

Back 551

Early (< 1 year)

Front 552

syphilis Congenital: early

Back 552

“saw-tooth” appearance of metaphysis, “snuffles”, Rhagades (Parrot’s lines), Pseudoparalysis of Parrot, “Syphilitic pemphigus”
Lymphadenopathy (epitrochlear)
Neurosyphilis

Hint 552

None

Front 553

syphilis Congenital: late (>2 yo)

Back 553

Mulberry molars, Hutchinson’s teeth (widely-spaced, peg-shaped upper incisors, Saddle nose, Saber shins, Clutton’s joints (non-tender, bilateral swelling of knees), higoumenakis sign, Eighth nerve deafness, Intersitial keratitis, Gummas Hutchinson’s triad

Hint 553

None

Front 554

chancroid organism and clinical

Back 554

H ducreyi; tender chancre, inguinal bubo in 50% (this is not groove sign)

Front 555

chancroid path

Back 555

school of fish

Front 556

granuloma inguinale organism

Back 556

calymmatobcterium granluomatis

Front 557

granuloma inguinale clinical

Back 557

subq nodule (pseudobubo) or ulcer then 4 forms: ulcerovegettive/nodular/hypertrophic/cictricial

Front 558

granuloma inguinale path

Back 558

donnovan bodies

Front 559

LGV organism

Back 559

chlamydia trachomatis L1-3

Front 560

LGV clinical

Back 560

painless like syphilis then nodes above and below pouprts (grove sign, can be bilateral). LGrooVe

Front 561

syphilis VDRL: + when, - when

Back 561

positive 4-5 wks , negative after tx

Front 562

syphilis RPR

Back 562

like vdrl (4-5 weeks + then negative after tx)

Front 563

syphilis FTA-ABS when +? How long +?

Back 563

pos by 3rd week, remians positive

Front 564

syphilis most sensitive test

Back 564

FTA-ABS

Front 565

syphilis Serologic test of choice in early primary and congenital syphilis because it is the first to become reactive

Back 565

Enzyme-Linked Immunosorbent Assay (ELISA)- Captia (IgM) EIA

Front 566

leishmaniasis old world - all

Back 566

TIMAd (tropica, infantum, major, aetheopia, donovani)

Front 567

leishmaniasis new world-all

Back 567

mexicana, braziliensis, amazonensis, adrianrodrigueznensis

Front 568

leishmaniasis cut leishmaniasis old and new

Back 568

(old) TIMA: (new)mex,braz,amaz

Front 569

leishmaniasis MCL

Back 569

L. aethiopica (Old World)

Front 570

leishmaniasis Visceral Leishmaniasis (VL; kala-azar)

Back 570

L. donovani

Front 571

leishmaniasis vectors (old and new)

Back 571

Phlebotomus (Old World)

Front 572

leishmaniasis Culture

Back 572

Novy-MacNeal-Nicolle (NNN)

Front 573

leishmaniasis tx

Back 573

Pentavalent antimony (sodium stibogluconate)

Front 574

Winterbottom’s sign

Back 574

african trypanosomiasis

Front 575

(Chagas’ Disease) organism

Back 575

T. cruzi

Front 576

(Chagas’ Disease) vector

Back 576

reduviid

Front 577

Filariasis organism

Back 577

Brugia malayi, Brugia timori, W banchrofti

Front 578

Filariasis vector, victor

Back 578

Aedes, Anopheles, Culex, or Mansonia

Front 579

Calabar swellings organism?

Back 579

loa loa (vector mango fly)

Front 580

loa loa tx

Back 580

DEC

Front 581

loa loa and onchocerciasis in common

Back 581

eye swimmers

Front 582

onchocerciasis vector + 3 clinicals

Back 582

simulium (black fly). Clinical: leoprd skin, onchocercal nodules over bony prominences, ocular involvement

Front 583

onchocerciasis tx

Back 583

ivermectin

Front 584

Strongyloidiasis Mode of Infection:

Back 584

penetration of larvae through skin or mucous membranes, usually from contact with

Front 585

Strongyloidiasis Cutaneous Strongyloidiasis aka

Back 585

larva currens

Front 586

Strongyloidiasis – Disseminated Strongyloidiasis: clinical sign

Back 586

thumbprint

Front 587

RMSF organism, vectors (east/west)

Back 587

r rickettsi. West: dermacentor andersoni and east: dermacentor variabilis

Front 588

rickettsialpox organsm, vector

Back 588

akari, liponyssoides sanguineus (mite of house mouse)

Front 589

epidemic typhus organism, vectors (east/west)

Back 589

prowazekii, body louse

Front 590

endemic typhus organism, vector

Back 590

r typhi, rat flea (xena)

Front 591

scrub typhus organism, vector

Back 591

tsutsugamshi, trombiculid

Front 592

q fever organism, vector

Back 592

coxiella burnetii, dried tick feces

Front 593

ehrlichiosis HME organism, vector

Back 593

chaffeensis. Amblyomma americanum

Front 594

ehrlichiosis HGE organism, vector

Back 594

phagocytophilia, ixodes scapularis, pacificus

Front 595

Sclerema Neonatorum clinical

Back 595

Often fatal entity• Rapidly progressive, woody hardening of the skin within the first few days of life

Front 596

Sclerema Neonatorum path

Back 596

needle-shaped clefts within necrotic adipocytes with little surrounding inflammation

Front 597

Subcutaneous Fat Necrosis of the Newbor resolution may be associated with

Back 597

profound hypercalcemia

Front 598

Pedal Papules of Infancy clinical

Back 598

Soft, non-tender papules located on the medial aspect of heel

Front 599

Aplasia Cutis Congenita 3 syndromes

Back 599

Barts, Setleis (bitemoproal APC, leonine facies, absent eyelashes), adams-olkliver

Front 600

Adams-Oliver syndrome: clinical

Back 600

CMTC with Aplasia cutis congenita

Front 601

Nevus Sebaceus Neoplasms associated:

Back 601

syringocystadenoma papilliferum > trichoblastoma. BCC < 1%

Front 602

Acrodermatitis Enteropathica/Zinc color

Back 602

Brown, orange crusted plaques

Front 603

Acrodermatitis Enteropathica/Zinc Inherited form:

Back 603

SLC39A4

Front 604

Jacquet’s Erosive Dermatitis etiology

Back 604

Multifactorial etiology: yeast, irritant dermatitis andmoisture

Front 605

Cystic Fibrosis clinical

Back 605

Resembles zinc deficiency

Front 606

biotin deficiency, multiple carboxylase deficiency clinical

Back 606

Resembles zinc deficiency but affects all biotin

Front 607

biotin deficiency, multiple carboxylase deficiency Neonatal form: inhertience and defect

Back 607

AR holocarboxylase synthetase

Front 608

biotin deficiency, multiple carboxylase deficiency Juvenile form: enzyme

Back 608

Biotinidase

Front 609

biotin deficiency, multiple carboxylase deficiency systemic findings

Back 609

Seizures, vomiting, hypotonia, ataxia 2° lacticacidosis/ketosis

Front 610

Kawasaki’s Disease 2/3 pts present with confluent, tender erythema in the

Back 610

perineum

Front 611

SSS phage

Back 611

grp II

Front 612

what kind of virus is coxsackie

Back 612

ssRNA picornavirus

Front 613

kawasakis 4 of 5 crietria..list them

Back 613

1. fever >5 d 2. palmar eryhtema 3. conjuctivitis 4. strawbery tongue/red lips 5. cervical LAD

Front 614

kawasakis tx

Back 614

ASA + IVIG

Front 615

HEPATITIS C VIRUS family

Back 615

flavi

Front 616

HEPATITIS C VIRUS : what account for 75% of infections

Back 616

types 1a, 1b

Front 617

HEPATITIS C VIRUS : what % of patients will progress to chronic Hepatitis

Back 617

70

Front 618

HEPATITIS C VIRUS : cirrhosis will develop in

Back 618

20-30

Front 619

HEPATITIS C VIRUS : % cirrhotic patients will develop hepatocellular cancer

Back 619

4-11%

Front 620

Cryoglobulinemia : % RF positive

Back 620

70-90

Front 621

PCT triggers

Back 621

alcohol, estrogens, polyhalogenated hydrocarbons, PCT

Front 622

PCT : mechanism of iron overload exacerbation

Back 622

formation of free iron radicals and oxidation of UROD

Front 623

Polyarteritis Nodosa : 2 viral associ

Back 623

HCV, HBV

Front 624

HCV : eye findings.

Back 624

Mooren corneal ulcers

Front 625

HCV tx

Back 625

IFNa and ribavirin

Front 626

Thyroglossal Duct Cyst Remnant of

Back 626

embryonic duct

Front 627

Most common cystic abnormality of neck

Back 627

Thyroglossal Duct Cyst

Front 628

Thyroglossal Duct Cyst Characteristic histologic feature

Back 628

thyroid follicles in cyst wall

Front 629

Multiple endocrine neoplasia (MEN) 2a, aka

Back 629

Sipple

Front 630

Multiple endocrine neoplasia (MEN) 2a, clinicals

Back 630

Medullary thyroid, pheo, parathyroid and cut AMYLOID

Front 631

MEN 2b/III clinicals

Back 631

medullary thyroid carcinoma, mucosal neuromaspheochromocytoma, marfanoid features, and gastrointestinal ganglioneuromatosis.

Front 632

Graves Disease hyper or hypo metabolic state?

Back 632

hypermetabolic state

Front 633

Graves Disease Clinical manifestations

Back 633

hyperthyroidism, goiter, pretibial myxedema

Front 634

Thyroid dermopathy: aka

Back 634

pretibial myxedema

Front 635

Thyroid dermopathy: occurs in which states

Back 635

hypo/hyper and euthymic

Front 636

Graves :cut conditions

Back 636

vitiligo, anetoderma, dermatitis herpetiformis,mid-dermal elastolysis, herpes gestationis, pemphigus vulgaris, and Sweet’s syndrome

Front 637

hyperthyroidism nails

Back 637

plummer (curved with distal onycholysis)

Front 638

hyperthyroidism :pigment associations?

Back 638

vitiligo

Front 639

hyperthyroidism : hands?

Back 639

palmar erytherma

Front 640

hyperthyroidism : hair?

Back 640

hypertrichosis

Front 641

: side effect of potassium idodide therapy

Back 641

Wolff-Chaikoff effect: inhibiiton of thyorid hormone synthesis

Front 642

hypothyroidism skin hue

Back 642

yellow 2/2 carotenemia

Front 643

hypothyroidism myxedemea type

Back 643

generalized

Front 644

hypothyroidism hair

Back 644

brittle, sparse, increased telogen #

Front 645

hypothyroidism eyebrows

Back 645

madarosis

Front 646

Xeroderma Pigmentosum (XP):UV irradiation induces specific types of DNA damage, primarily,

Back 646

cyclobutane pyrimidine dimers (CPDs) and 6–4

Front 647

Xeroderma Pigmentosum (XP):xp types recognizing damaged DNA

Back 647

XPA,XPE

Front 648

Xeroderma Pigmentosum (XP):xp types unwinding the coiled DNA

Back 648

XPB, XPD

Front 649

Xeroderma Pigmentosum (XP):xp types repairing the localized damaged DNA

Back 649

endoculeases XPF, XPG

Front 650

Xeroderma Pigmentosum (XP):most sever variant and inheritence

Back 650

desanctis cacchione - AR XPA

Front 651

Xeroderma Pigmentosum (XP):XPB = ercc?

Back 651

ercc3

Front 652

Xeroderma Pigmentosum (XP):XPB clinically

Back 652

pigmentary retinopathy, basal ganglia calcification

Front 653

Xeroderma Pigmentosum (XP):XPB crosses over with what

Back 653

Cockayne

Front 654

Xeroderma Pigmentosum (XP):XPD crosses over with what dz

Back 654

PIBIDS

Front 655

Xeroderma Pigmentosum (XP):XPD=ercc?

Back 655

ercc2

Front 656

Xeroderma Pigmentosum (XP):XPF=ercc?

Back 656

ercc4

Front 657

Xeroderma Pigmentosum (XP):XPG is a homologue of what gene

Back 657

yeast RAD2

Front 658

Cockayne Syndrome:inheritence

Back 658

AR

Front 659

Cockayne Syndrome:ercc?

Back 659

ercc8

Front 660

Cockayne Syndrome:clinical

Back 660

Cataracts, deafness, pigmentary retinopathy, dental caries., “Wizened” appearance, “bird-headed” facies,“Mickey Mouse” ears

Front 661

Cockayne Syndrome:early death from

Back 661

pneumonia

Front 662

PIBIDS:stands for

Back 662

photosensitivity (like XPD), ichthyosis, brittle hair, intellect, decreased fertiliy, short

Front 663

Hutchinson-Gilford Progeria Syndrome:Defect in

Back 663

lamin A

Front 664

Werner Syndrome:Defect in

Back 664

RECQL2

Front 665

Rothmund-Thomson Syndrome:Defect in

Back 665

RECQL4 gene defect

Front 666

Rothmund-Thomson Syndrome:clinical

Back 666

Poikiloderma, photosensitivity, sparse hair, atrophic nails,

Front 667

Rothmund-Thomson Syndrome:weird findings

Back 667

juvenile zonular cataracts, annular pancreas,

Front 668

Rothmund-Thomson Syndrome:Increased malignancy:

Back 668

basal cell carcinoma, squamous cell carcinoma, osteogenic sarcoma

Front 669

Ataxia-Telangiectasia:aka

Back 669

(Louis-Bar Syndrome)

Front 670

Ataxia-Telangiectasia:Milder AT-like syndrome due to what mutation

Back 670

MREII gene defect).

Front 671

Ataxia-Telangiectasia:Increased malignancy:

Back 671

leukemia and lymphoma.

Front 672

Ataxia-Telangiectasia:increased risk of malignancy in heterozygotes

Back 672

esp: breast cancer

Front 673

Ataxia-Telangiectasia:atatxia at 1 year old, telangectasia ye, but what immunodeficiency?

Back 673

thymic hypoplasia with defect B-cells and decrease number of T-cells,

Front 674

Ataxia-Telangiectasia:lab abnormality?

Back 674

CEA

Front 675

Bloom Syndrome:gene

Back 675

recql3

Front 676

Bloom Syndrome:clinical

Back 676

prenatal growth deficiency, photosensitivity, midfacial telangiectasia, dyspigmentation,

Front 677

Fanconi Anemia:skeletal

Back 677

radial ray defects

Front 678

Fanconi Anemia:why anemic?

Back 678

All marrow elements are usually affected, resulting in anemia, leukopenia, and thrombocytopenia

Front 679

Dyskeratosis Congenita:similarity with naegeli?

Back 679

absnt dermatoglyphs

Front 680

Ichthyosis Vulgaris:gene/product

Back 680

filligrin/profilligrin.

Front 681

XL ichthyosis:associations (3)

Back 681

corneal opacities, cryptorchidism, prolonged labor

Front 682

Epidermolytic Hyperkeratosis:aka

Back 682

(Congenital Bullous Ichthyosiform Erythroderma)

Front 683

Epidermolytic Hyperkeratosis:gene defects

Back 683

K1,10

Front 684

Epidermolytic Hyperkeratosis:if in epidermal nevus

Back 684

Localized forms may affect germline...risk for babies

Hint 684

None

Front 685

Lamellar Ichthyosis:at birth

Back 685

Collodion baby, ectropion, eclabion, alopecia

Front 686

Nonbullous Congenital Ichthyosiform Erythroderma):defects

Back 686

transglutaminase-1 gene, 12R-lipoxygenase gene, and the lipoxygenase-3 gene

Front 687

Nonbullous Congenital Ichthyosiform Erythroderma):birth

Back 687

Collodian baby (90%)

Front 688

Harlequin Fetus:inheritence

Back 688

ar

Front 689

Restrictive Dermopathy:clinical

Back 689

Tight, restrictive adherent skin at birth associated with fixed, pinched facies.

Front 690

Erythrokeratoderma Variabilis:genes

Back 690

connexins 31 and 30.3

Front 691

Netherton Syndrome:triad

Back 691

IL, atopy, trichorrhexis invaginata

Front 692

Keratitis, Ichthyosis and Deafness Syndrome (:gene

Back 692

cx26

Front 693

Sjogren-Larsson:eye

Back 693

gistening white dots

Front 694

Refsum Disease:genes in adult and kids

Back 694

phytanoylCoa. Kids: PEX1,2

Front 695

Refsum Disease:nevi?

Back 695

yellow nevi

Front 696

Refsum Disease:clinical

Back 696

retinitis pigmentosa, ataxia, polyneuritis, deafness, cardiomyopathy

Front 697

Refsum Disease:bone

Back 697

4th metatarsal shortening

Front 698

Chondrodysplasia Punctata:XR type. Gene

Back 698

arylsulfatase E

Front 699

Chondrodysplasia Punctata:XR type clinical

Back 699

Ichthyosis, hypogonadism, and anosmia

Front 700

Chondrodysplasia Punctata:contiguous gene syndrome

Back 700

Xlinked ichthyosis, kallman

Front 701

Conradi-Hunermann Syndrome):inheritence

Back 701

XD variant of condrodyplasia punctata

Front 702

Conradi-Hunermann Syndrome):gene

Back 702

EBP

Front 703

Conradi-Hunermann Syndrome):clinical

Back 703

ichthyosis and erythroderma along Blaschko’s lines, follicular atrophoderma,

Front 704

Rhizomelic Chondrodysplasia Punctata:genes for each of the 3 types

Back 704

type 1: PEX7; type 2 DHAPAT; type 3: alkyl-AP synthetase

Front 705

chondrodysplasia punctata:AD variant unique feature

Back 705

Koala bear facies

Front 706

Acrokeratosis Verruciformis of Hopf:gene

Back 706

ATP2A2 gene mutation (allelic to Darier disease)

Front 707

Darier Disease (Keratosis Follicularis):gene

Back 707

SERCA2 Ca(2+)-ATPase

Front 708

Darier Disease (Keratosis Follicularis):nails

Back 708

red or white longitudinal streaking of nails with distal V notching.

Front 709

Pachyonychia Congenita:associations types 2

Back 709

natal teeth, steatocystoma multiplex, epidermal inclusion cysts

Front 710

Steatocystoma Multiplex:gene

Back 710

k17

Front 711

Nail-Patella Syndrome:lmx1b. Nails?

Back 711

triangular lunula

Front 712

Nail-Patella Syndrome:systemic

Back 712

renal, absent patella, iliac horns

Front 713

Vorners:defect. Epidermolytic?

Back 713

k9. Yes.

Front 714

Vorners:appearance

Back 714

sharply demarcate

Front 715

Unna Thost:epidermolytic?

Back 715

nonepidermolytic

Front 716

Unna Thost:genes

Back 716

k1,16

Front 717

mosaib K16 mutation:clinically

Back 717

unilateral palmoplantar verrucous nevus

Front 718

keratoderma hereditaria mutilans:aka, gene

Back 718

vohwinkles, cx26 (loricrin without deafness)

Front 719

keratoderma hereditaria mutilans:gene

Back 719

starfish keratosis, pseudoainhum, linear plaques on knees, bilateral deafness

Front 720

striated ppk:gene

Back 720

dsg1

Front 721

Howell-Evans:type of ppk

Back 721

nonepidermolytic

Front 722

Mal de meleda:clinical

Back 722

erythematous ppk, hyperhidrosis

Front 723

Mal de meleda:transgrediens or no?

Back 723

yes

Front 724

Papillon-lefevre:type of ppk

Back 724

erythematous ppk

Front 725

HAIM Munk:gene

Back 725

cathepsin C

Front 726

HAIM Munk:clinical

Back 726

papillon lefevre with onychogryphosis, pes planus

Front 727

Naxos:heart defect, gene

Back 727

right sides conduction, plakoglobin

Front 728

Carvajal:heart defect, gene

Back 728

left dilated cardiomyopathy, desmoplakin

Front 729

Olmsted Syndrome:clinical

Back 729

Sharply defined PPK with periorificial, keratotic lesions +/- pseudoainhum,

Front 730

Anhidrotic Ectodermal Dysplasia:inheritence and genes (two type)

Back 730

XR: EDA; AD: EDAR

Front 731

Ectodermal Dysplasia (Margarita Island Type):gene

Back 731

Cell-cell adhesion molecule/herpes virus receptor, PVRL1 gene mutation

Front 732

Ectodermal Dysplasia (Margarita Island Type):alelic to

Back 732

Allelic disorder to the Zlotogora-Ogur syndrome

Front 733

Ectodermal Dysplasia/Skin Fragility Syndrome:aka

Back 733

McGrath

Front 734

Ectodermal Dysplasia/Skin Fragility Syndrome:defect

Back 734

Plakophilin-1

Front 735

Menkes Kinky Hair Syndrome:hair

Back 735

Pili torti (occ. trichorrhexsis nodosa)

Front 736

Menkes Kinky Hair Syndrome:systemic

Back 736

severe neurological deterioration secondary to copper accumulation, Wormian bones

Front 737

Papular Atrichia:Defect in human homolog of

Back 737

mouse hairless gene

Front 738

OCA type 1:product

Back 738

tyrosinase

Front 739

Yellow mutant:type 1B (OCA1 is type 1A). Gene?

Back 739

tyroinase-clinical improve over time.

Front 740

OCA type 2:gene

Back 740

P gene

Front 741

OCA:most common form

Back 741

OCA2

Front 742

Brown OCA:what tye OCA is it?

Back 742

OCA3

Front 743

Brown OCA:gene

Back 743

TRP-1

Front 744

Chediak-Higashi Syndrome:accumulation of what?

Back 744

ceroid-like material

Front 745

Chediak-Higashi Syndrome:die from

Back 745

accelerated phase

Front 746

McCune-Albright Syndrome (:aka

Back 746

(Polyostotic Fibrous Dysplasia)

Front 747

McCune-Albright Syndrome (:gene

Back 747

GNAS

Front 748

JEB:genes for 1 herlitz, 2 nonherlitz, 3 pyloric atresia

Back 748

1. Lam5 2. Lam5,collXVII, 3. A6b4

Front 749

NF2:eye

Back 749

juenile posterior subcapsular cataracts

Front 750

NF3:clinical

Back 750

larger café au laits, palmar NFs, acoustin neuromas

Front 751

NF5 :clinicl

Back 751

segmental

Front 752

NF6:clinical

Back 752

café au lait macules only (>6)

Front 753

TS:oral (2)

Back 753

dental pits, ginigval fibromas

Front 754

Gorlin:brain

Back 754

medulloblastoma, meningiomas

Front 755

Muir Torre:clinical

Back 755

sebaceous, KA, BCC

Front 756

Carney:4 tumors

Back 756

Psammomatous melanotic schwannomas. Atrial myxomas. Sertoli cell tumors, pheos

Front 757

Carney:NAME

Back 757

nevi, atrial myxomas, myxoid tumors, ephilides

Front 758

Carney:LAMB

Back 758

lentigines, atria myxomas, mucocutaneous myxomas, blue nevi

Front 759

Petuz-Jeghers:GI cancers?

Back 759

slight increase

Front 760

Petuz-Jeghers:other cancers

Back 760

Breast, sertoli, thyroid, uterine, ovarian sex chord.

Front 761

Brooke-Spiegler syndrome):triad

Back 761

TE, cylindromas, milia

Front 762

Pilomatrichoma:2 syndromes

Back 762

1. Myotnic dystrophy 2. Rubenstein taybi (CREB)

Front 763

Gaucher:product

Back 763

B-glucocerebrosidase

Front 764

Fabry:a-galactosidase

Back 764

a-galactosidase

Front 765

fucosidosis:product

Back 765

L-fucosidase

Front 766

fucosidosis:looks like

Back 766

Fabry's

Front 767

Hartnup:enzyme

Back 767

tryptophan

Front 768

Hartnup:clinical

Back 768

like pellagra

Front 769

Prolidase def:clinical

Back 769

lower leg ulceration

Front 770

Alkaptonuria:enzymes

Back 770

HGO

Front 771

Wilson:nail

Back 771

blue lunula

Front 772

Tyroinemia II:clinical

Back 772

painful ppk

Front 773

Hurler:a-L-iduronidase

Back 773

Dermal melanocytosis. corneal clouding, dysostosis multiplex,

Front 774

Hunter:Iduronidate sulfatase

Back 774

Iduronidate sulfatase

Front 775

Hunter:clinicl

Back 775

pebbly skin lesions on scapula

Front 776

EDS gravis:defect

Back 776

Col V

Front 777

EDS mitis:defect

Back 777

Col V

Front 778

EDS hypermobile:defect

Back 778

col III

Front 779

EDS vascular:defect

Back 779

Col IV

Front 780

EDS kyphoscoliosis:defect

Back 780

lysyl hydroxylase

Front 781

EDS arthrochalasia:defect

Back 781

Col1alpha1, alpha2

Front 782

EDS dermatosparaxis:defect

Back 782

ADAMTS2

Front 783

Cutis Laxa:defect AR, AD

Back 783

AR FBLN5; AD elasti

Front 784

Cutis Laxa:AR form versus AD form

Back 784

AR only skin findings (no pulmonary, vascular etc)

Front 785

Pseudoxanthoma Elasticum:oral

Back 785

Yellowish papules on lip mucosa,

Front 786

Pseudoxanthoma Elasticum:eye

Back 786

Angiod streaks, blue sclera

Front 787

Osteogenesis Imperfecta:defect

Back 787

COL1A1 gene defect

Front 788

Tuberous Sclerosis:earliest cutaneous finding,

Back 788

Hypopigmented macules

Front 789

Tuberous Sclerosis:oral

Back 789

dental pitting

Front 790

Fabry’s Disease:accumulation of what in vascular

Back 790

globotriaosylceramide,

Front 791

Fabry’s Disease:renal failure is due to accumulation of

Back 791

ceramide trihexoside

Front 792

Birt-Hogg-Dube Syndrome:Triad of

Back 792

trichodiscomas, fibrofolliculomas and acrochordons

Front 793

Birt-Hogg-Dube Syndrome:tumors

Back 793

bilateral renal tumors, Periodic surveillance of patients and their relatives for renal cell carcinoma is recommended

Front 794

Nail-Patella Syndrome:LMX1B gene, which encodes a transcription factor involved in

Back 794

collagen synthesis

Front 795

Nail-Patella Syndrome:eye

Back 795

hyperpigmentation of the papillary margin of the iris (Lester iris)

Front 796

Pseudoxanthoma Elasticum (PXE):ABCC6 gene, which encodes the

Back 796

MRP6 protein (functions as efflux pump)

Front 797

Pseudoxanthoma Elasticum (PXE):ABCC6 expressed where?

Back 797

expressed in hepatocytes and renal cells

Front 798

Pseudoxanthoma Elasticum (PXE):eye

Back 798

Bruch’s membrane of the eye (angioid streaks)

Front 799

Pseudoxanthoma Elasticum (PXE):Histopathology:

Back 799

fragmented elastic fibers in the mid and deep reticular dermis

Front 800

metaststaic calcification:It can manifest in the skin what 2 ways?

Back 800

benign nodular calcifications (calcinosis cutis) or as a more serious condition

Front 801

NFD:cell immunostain

Back 801

CD34+ more than scleroderma

Front 802

Pseudo-PCT:drugs

Back 802

PLANT: pyridxoine, lasix, amiodarone, naproxen, tetracycline

Front 803

Hereditary Hemorrhagic Telangiectasia:mutations in

Back 803

ENG or ACVRLK1 genes encoding endoglin and ALK

Front 804

Blue Rubber Bleb Nevus Syndrome:gene

Back 804

VMCM1

Front 805

Malignant Atrophic Papulosis of Degos:path

Back 805

epidermal atrophy overlying wedge-shaped dermal necrosis and mucinous degeneration

Front 806

Malignant Atrophic Papulosis of Degos:Systemic:

Back 806

GI bleeding, cramping, perforation,

Front 807

Gardner’s Syndr:Epidermoid cysts in 5% of cases.

Back 807

100%

Front 808

Gardner’s Syndr:other tumors besidesd EIC colon

Back 808

desmoid tumors, osteomas of mandible/maxilla,supranummery teeth

Front 809

Gardner’s Syndr:early sign

Back 809

MRP6 protein (functions as efflux pump)

Front 810

Muir Torre:Triad of

Back 810

sebaceopus, BCC, KA

Front 811

Peutz-Jeghers Syndrome:have mutations in

Back 811

STK11 gene, which encodes a serine threonine

Front 812

Peutz-Jeghers Syndrome:Systemic:

Back 812

Hamartomatous intestinal polyps with intussusception

Front 813

Peutz-Jeghers Syndrome:other cancers besides some colonc cancers

Back 813

breast, ovarian, and testicular cancer

Front 814

Wermers’s syndrome”::aka

Back 814

MENI

Front 815

“Sipple’s Syndrome”::aka

Back 815

MEN Iia

Front 816

Wasserman-Froebose (sp?):aka

Back 816

MEN Iib (or III)

Front 817

MEN I:clinics

Back 817

Ps: parathyroid, pancreatic, pituitary, prolactinomas

Front 818

MEN I:what happens in the stomach?

Back 818

peptic ulcer from zollinger ellison

Front 819

MEN Iia:cutanous

Back 819

amyloid

Front 820

MEN Iib:clinical

Back 820

medularry thyroid, mucosal neuromas, marfanoid, pheochromo (3M plastics)

Front 821

Bowel-Associated Dermatosis-Arthritis Syndrome:etiology

Back 821

Involves bowel bacterial overgrowthÕ complement activation with subsequent deposition of

Front 822

DH:HLAs

Back 822

B8, DQ2, DR3

Front 823

DH:Cutaneous findings are due to autoantibodies to

Back 823

transglutaminase

Front 824

DH:% with symptoms of their gluen enteropathy?

Back 824

20%

Front 825

DH:antibody target for GI problem

Back 825

gliadin

Front 826

Erythema Nodosum:more Crohns or UC?

Back 826

UC

Front 827

Pyoderma Gangrenosum:more crohns or UC?

Back 827

uc

Front 828

Polyarteritis Nodosa:more assoc with crohns or UC?

Back 828

Crohns

Front 829

NF1:brain

Back 829

UFOs (well, really UBOs) in basal ganglia

Front 830

NF1:eye

Back 830

lisch

Front 831

BCNS:PTCHed function

Back 831

Inactivating PTCH mutations leads to loss of inhibition of smoothen (SMO)

Front 832

BCNS:brain

Back 832

Systemic: falx cerebri calcifications, ageneis of the corpus callosum,

Front 833

BCNS:brain tumor?

Back 833

medulloblastoma,

Front 834

BCNS:chest wall?

Back 834

bifid ribs, pectus deformity

Front 835

Ataxia-Telangiectasia (AT):ATM encodes what?

Back 835

phosphatidylinositol 3-kinase-

Front 836

Ataxia-Telangiectasia (AT):malignant neoplasms,

Back 836

(B-cell lymphomas and T-cell chronic

Front 837

Ataxia-Telangiectasia (AT):immune defect?

Back 837

impaired humoral (absent IgA, E..reduced IgG

Front 838

Incontinentia Pigmenti:inheritence

Back 838

X-linked dominant,

Front 839

Incontinentia Pigmenti:gene function

Back 839

NEMO: activates NFkB thereby protecting against TNF a induced apoptosis.

Front 840

Piebaldism:Systemic:

Back 840

cerebellar ataxia, mental retardation, deafness

Front 841

KID Syndrome (Keratitis-Ichthyosis-Deafness):what gene encodes cx26?

Back 841

GJB2

Front 842

IBIDS Syndrome:XPD is which ERCC? XPB?

Back 842

XPD ERcc2; XPB ERCC3

Front 843

Sjorgen-Larsson Syndrome:Clinical triad of

Back 843

congenital ichthyosis, di- or tetraplegia, mental retardation

Front 844

Sjorgen-Larsson Syndrome:what kind of -plegia?

Back 844

di or tri

Front 845

Sjorgen-Larsson Syndrome:eye

Back 845

perifoveal glistening white dots,

Front 846

Bjornstad’s Syndrome:clinical

Back 846

pili torti and deafness

Front 847

Menkes Disease:Diagnosis made by

Back 847

Diagnosis made by

Front 848

Cockayne Syndrom:mutation of unknown gene results in inability to repair

Back 848

cyclobutane dimers induced by UV

Front 849

Cockayne Syndrom:brain

Back 849

basal

Front 850

Refsum Disease:heart defect?

Back 850

atrioventricular and bundle branch block, cardiomyopathy,

Front 851

Refsum Disease:Diagnosis made by

Back 851

elevated serum phytanic acid

Front 852

Refsum Disease:Treatment:

Back 852

dietary restriction of phytanic acid: dairy

Front 853

HAIRAN syndrome:

Back 853

#VALUE!

Front 854

Approximately a% of NLD patients have diabetes or glucose intolerance. Conversely, only b% of DM have NLD:

Back 854

a=20, b-3

Front 855

Diabetic Bullae or Bullosis Diabeticorum:Clinical timing

Back 855

rapid onset of painless tense blisters on the hands and feet

Front 856

Erosio interdigitale blastomycetica:bug?

Back 856

candida

Front 857

erythrasma:bug?

Back 857

(Corynebacterium minutissimum).

Front 858

DM:this occurs in uncontrolled diabetics with ketosis.

Back 858

Rhinocerebral mucormycoses

Front 859

Marfan’s Syndrome:defect

Back 859

fibrillin1

Front 860

Marfan’s Syndrome:clinical

Back 860

Striae distensae on pectoral, deltoid, buttock, thighs, breasts,

Front 861

Marfan’s Syndrome:heart valves

Back 861

MVP

Front 862

Marfan’s Syndrome:lense dislocation

Back 862

upward

Front 863

Cutis Laxa:aka

Back 863

generalized elastolysis

Front 864

Cutis Laxa:Type III is what ?

Back 864

acquired

Front 865

Cutis Laxa:acquired form: what drugs?

Back 865

pencicillamine

Front 866

Osteogenesis Imperfecta:mutation in

Back 866

COL1A1 or COL1A2

Front 867

Homocystinuria:deficiency of

Back 867

cystathionine beta synthase,

Front 868

Homocystinuria:lens?

Back 868

downward

Front 869

Noonan’s Syndrome:hair

Back 869

woolly hair,

Front 870

Noonan’s Syndrome:4 skin things

Back 870

muliple melanocytic nevi, lymphedema, ulerythema ophyrogenes, keratosispilaris atrophicans

Front 871

Noonan’s Syndrome:loaded

Back 871

pilaris atrophicans

Front 872

Noonan’s Syndrome:systemic -heart

Back 872

Hypertrophic cardiomyopathy,

Front 873

Noonan’s Syndrome:genitals

Back 873

cryptorchidism

Front 874

Noonan’s Syndrome:gene

Back 874

ptpn11

Front 875

Werner’s:gene

Back 875

WRN (Recql2)

Front 876

LEOPARD:gene

Back 876

ptpn11

Front 877

LEOPARD:genitals

Back 877

hypoplasia,cryptorchidism

Front 878

LAMB::?

Back 878

Lentigines (face and mucoas), Atrial myxoma (complicated by CHF, angina, pulmonary edema, and embolic events),Mucocutaneous myxoma, Blue nevi (spares hand and feet)

Front 879

LAMB::blue nevi spare what

Back 879

hands and feet

Front 880

NAME:?

Back 880

Nevi, Atrial myxomas,Myxoid neurofibromata, Ephilides and Endocrine neoplasms

Front 881

Carney cancers:

Back 881

breast adenomas, psammamatous schwannomas

Front 882

Naxos Disease:heart

Back 882

Arrhythmogenic right ventricular cardiomyopathy

Front 883

glucagonoma:% metastatic at diagnosis

Back 883

75%

Front 884

Porphyria Cutanea Tarda:Photosensitivity in porphyria caused by absorption of UVR what wavelength

Back 884

soret 400-410

Front 885

heme synthesisproducts

Back 885

All people having urine can pp: ALA, PBG, HMB, UPCIII/I, CPIII, PPPIX, PPIX

Front 886

PCT:enzyme

Back 886

UPD

Front 887

sideroblastic anemia (x-linked):enzyme

Back 887

ALA synth

Front 888

ALAd-deficient porphyria:enzyme

Back 888

ALAd

Front 889

AIP:enzyme

Back 889

PBD

Front 890

CEP:enzyme

Back 890

UPC

Front 891

Hereditary copropoporhyria :enzyme

Back 891

CPO

Front 892

Variegate porphyria:enzyme

Back 892

PPO

Front 893

EPP:enzyme

Back 893

ferro

Front 894

mitochondrial steps in porphryia:

Back 894

1st:ala-synth and last 2: PPO, ferrochelatase

Front 895

If heme inadequate, ? synthetase activity increases:

Back 895

dALA synthetase

Front 896

PCT:Urine

Back 896

uroporphyrins:coproporphyrins 3:1

Front 897

PCT:stool

Back 897

low copro

Front 898

Hepatoerythropoietic Porphyria:enzyme

Back 898

UPD homozygote

Front 899

Hepatoerythropoietic Porphyria:urine - color and ratio

Back 899

Dark, red urine at birth..3:1

Front 900

CEP vs HEP:rbcs

Back 900

CEP has elevated uroporphyrins in the RBC’s, and HEP doesn’t, but HEP has elevated RBCprotoporphyrins

Front 901

Acute Intermittent Porphyria:clinical

Back 901

colic..no skin lesions

Front 902

Acute Intermittent Porphyria:cancer risk

Back 902

liver

Front 903

Acute Intermittent Porphyria:test and eponym for test

Back 903

elevated PBG (wtason schwarz)

Front 904

Hereditary copropoporhyria :attacks of

Back 904

Attacks of neurological and GI symptoms like AIP

Front 905

Hereditary copropoporhyria :stool

Back 905

Fecal coproporphyrin always increased

Front 906

Hereditary copropoporhyria :urine

Back 906

Urinary copro, ALA, and PBG increased only during attacks

Front 907

porphyrias::aggravating drugs

Back 907

barbiturates, estrogen, griseofulvin, sulfonamides, alcohol, pregnancy

Front 908

VP:clinical

Back 908

like PCT + AIP (hereditary CP is similar)

Front 909

VP:stool

Back 909

proto > copro

Front 910

VP:urine

Back 910

coproporphyrins increased over uroporphyrins (inverse of PCT)

Front 911

VP:flourescence

Back 911

626

Front 912

Erythropoietic Protoporphyria:Immediate burning of skin on sun exposure. Whats the porphyrin?

Back 912

protoporphyrin IX absorbs in the Soret band

Front 913

Erythropoietic Protoporphyria:spectrum

Back 913

visible light through window glass can precipitate symptoms;

Front 914

only oxidized porphyrin in the heme pathway:

Back 914

protoporphyrin IX

Front 915

Erythropoietic Protoporphyria:urine

Back 915

normal

Front 916

Erythropoietic Protoporphyria:rbcs

Back 916

protoporphyrin elevated

Front 917

Hypertrichosis languinosa acquisita: cancer

Back 917

Lung carcinoma

Front 918

Acquired ichthyosis: cancers

Back 918

"Hodgkins lymphoma, Õ

Front 919

glucagonoma:% metastatic at diagnosis

Back 919

75%

Front 920

PP: cancers

Back 920

Non-Hodgkins lymphoma, Chronic lymphocytic leukemia Thymoma Castleman’s tumor Sarcoma

Front 921

PP antigens

Back 921

desmoplakin (250KD), envoplakin (210KD), BPAg-1(230 KD), periplakin (190 KD), desmogleins 3 and 1.

Front 922

Dermatomyositis:cancers in men

Back 922

gastric carcinoma and lymphoma

Front 923

Acquired ichthyosis: cancers

Back 923

Hodgkins lymphoma, breast and lung carcinoma

Front 924

Anagen:% hairs in phase

Back 924

90

Front 925

Catagen:% hairs in phase

Back 925

1%

Front 926

Telogen:%hairs in phase

Back 926

10%

Front 927

Pili Torti:5 syndromes

Back 927

ACQUIRED; Menkes; Bjornstads; Crandalls; Bazex DC

Front 928

Menke’s:ingeritence

Back 928

X-linked recessive,

Front 929

Menke’s:gene

Back 929

atp7a (MNK)

Front 930

Menke’s:arteries

Back 930

tortuous

Front 931

Menke’s:lips

Back 931

cupids bow

Front 932

Menke’s:CNS

Back 932

seixzures

Front 933

Menke’s:hair (3)

Back 933

pili torti, monilithrix, trich nodosae

Front 934

Bjornstads:clinical (2)

Back 934

Pili torti + sensorineural deafness

Front 935

Bjornstads:clinical (3)

Back 935

Pili torti + deafness + hypogonadism

Front 936

Trichorrhexis Nodosa:6 syndromes

Back 936

acquired; arginosuccinic aciduria; citrullinemia; menkes; PIBIDS; Nethertons

Front 937

Argininosuccinic aciduria:labs (2)

Back 937

low serum arginine, hyperammonemia

Front 938

Argininosuccinic aciduria:very strange hair finding besides t nodosa

Back 938

red flourescence of hair

Front 939

Marinesco-Sjögren:cns

Back 939

Cerebellar ataxia, mental retardation

Front 940

Marinesco-Sjögren:eyes

Back 940

Bilateral congenital cataracts

Front 941

Marinesco-Sjögren:bones

Back 941

(kyphoscoliosis, pes planovalgus)

Front 942

Marinesco-Sjögren:genitals

Back 942

Hypergonadotropic hypogonadism

Front 943

Netherton’s syndrome:triad

Back 943

Ichthyosis linearis circumflexa, atopy, trichorrhexis nodosa

Front 944

Monilethrix:mutations in hair keratins

Back 944

hHB6 and hHB1

Front 945

Monilethrix:have some features similar to what other syndrome?

Back 945

ED syndactyly, cataract, nail/teeth abnormalities

Front 946

Rothmund-Thomson Syndrome:gene

Back 946

RECQL4

Front 947

Rothmund-Thomson Syndrome:aka

Back 947

(Poikiloderma Congenitale)

Front 948

Rothmund-Thomson Syndrome:hair

Back 948

sparse

Front 949

Rothmund-Thomson Syndrome:eyes

Back 949

juvenile cataract

Front 950

Rothmund-Thomson Syndrome:ballsticles

Back 950

hypogonadism

Front 951

Rothmund-Thomson Syndrome:skin

Back 951

poikiloderma

Front 952

Cloustons:whats normal

Back 952

teeth, sweat

Front 953

Chondrodysplasis Punctata:acquired type?

Back 953

warfarin embryopathy

Front 954

Tricho-rhino-phalangeal Syndrome:gene

Back 954

TRPS1gene

Front 955

Tricho-rhino-phalangeal Syndrome:nose

Back 955

pear shaped

Front 956

Ectrodactyly-ectodermal Dysplasia-Clefting:other defects besides EEC

Back 956

genitourinary

Front 957

Trichodentoosseous Syndrome:gene

Back 957

distal-less homeobox-3 gene (DLX3)

Front 958

Trichodentoosseous Syndrome:hair

Back 958

Curly hair that tend to straighten by 2nd or 3rd decade

Front 959

Trichodentoosseous Syndrome:teeth

Back 959

Enamel hypoplasia, dental pits like TS

Front 960

Trichodentoosseous Syndrome:bones

Back 960

Increased bone density

Front 961

Noonan Syndrome:hair line

Back 961

low set posterior

Front 962

Noonan Syndrome:lungs

Back 962

pulm stenosis

Front 963

Noonan Syndrome:neck

Back 963

webbed

Front 964

Cornelia de Lange Syndrome:hair line

Back 964

low set

Front 965

Cornelia de Lange Syndrome:eyebrows

Back 965

unibrow

Front 966

Cornelia de Lange Syndrome:skin

Back 966

cutis marmorata

Front 967

Cornelia de Lange Syndrome:systemic defect

Back 967

heart

Front 968

Klippel-Feil:hair line

Back 968

low set posterior

Front 969

Klippel-Feil:eyes

Back 969

Strabismus, nystagmus,

Front 970

Klippel-Feil:mouth/perioral

Back 970

cleft palate, bifid uvula

Front 971

Tuberous Sclerosis:spontaneous mutation rate

Back 971

75%

Front 972

Klippel-Feil:hair/eyes/mouth

Back 972

low set hairline / strabismus / bifid uvula and cleft palate

Front 973

Vogt-Koyanagi-Harada:triad

Back 973

(Poliosis, Uveitis, Deafness, Vitiligo)

Front 974

Vogt-Koyanagi-Harada:etiology

Back 974

Autoimmune reaction to uveal melanin

Front 975

Telogen Effluvium:causes

Back 975

Endocrine (post-partum, thyroid disease), Nutritional (kwashiorkor), Drug (coumadin, heparin, ACE inhibitors, beta blocker, lithium, oral contraceptives, retinoids), Stress (illness, anemia, surgery)

Front 976

Telogen Effluvium:drug causes

Back 976

BALD = beta blockers, ACEi, Lithium, DIC panel (OCP, coumadin, heparin). You like it

Front 977

Anagen Effluvium:what heavy metals

Back 977

Mercury (contaminated seafood, antiseptic, fungicide), thallium

Front 978

Anagen Effluvium:why did Adrian get it killing cucharachas?

Back 978

Boric acid (insecticides)

Front 979

Androgenetic Alopecia:classifications men and women

Back 979

"(Hamilton-Norwood classification). Type VII is the most handsome. Wom,en: (Ludwig

Front 980

Androgenetic Alopecia:enzyme

Back 980

Type II 5-alpha reductase activity

Front 981

Wooly hair nevus:eye?

Back 981

persistent papillary membrane or retinal abnormality

Front 982

Papular Atrichia:gene

Back 982

Hairless gene

Front 983

Papular Atrichia:developing when?

Back 983

developing shortly after birth

Front 984

Icthyosis Follicularis, Atrichia, Photophobia (IFAP):exists

Back 984

it exists, just make a note of it

Front 985

Follicular Degeneration Syndrome:path

Back 985

premature desquamation of the inner root sheath with fibrosis

Front 986

LPP:path

Back 986

lymphohistiocytic infiltrate around the isthmus of the follicle associated with fibrosis and atrophy

Front 987

Parry-Romberg syndrome:3 things

Back 987

(linear morphea, progressive facial hemiatrophy, exophthalmos)

Front 988

scarring alopecia and generalized KP:what is this syndrome?

Back 988

Keratosis Follicularis Spinulosa Decalvans

Front 989

Inflammation, boggy induration, crust, pustules on scalp:suppurative follicuiltis on path..what is this syndrome?

Back 989

Folliculitis Decalvans

Front 990

Aplasia Cutis Congenita:Association with

Back 990

trisomy 13, Adams-Oliver syndrome, BARTS

Front 991

Epidermolytic Hyperkeratosis:

Back 991

Dehydroepiandrosterone (DHEA):

Front 992

Androgens in Women:adrenal, ovary

Back 992

Androstenedione:

Front 993

Androgens in Women:Testosterone: comes from

Back 993

ovary, adrenal, extraglandular conversion of androstenedione and dehydroepiandrosterone

Front 994

Androgens in Women:Adrenal androgen regulated by

Back 994

adrenocorticotropin

Front 995

Androgens in Women:Ovarian androgen regulated by

Back 995

luteinizing hormone

Front 996

Hirsutism without virilization/:drugs

Back 996

phenytoin, minoxidil, diazoxide, cyclosporin, hexachlorobenzene

Front 997

Tumors:Rapid onset of hair growth with or without accompanying virilization: what cancers

Back 997

Adrenal adenomas and carcinomas, Arrhenoblastoma, Kruckenberg tumors of ovary

Front 998

Congenital Adrenal Hyperplasia (CAH):Types of CAH

Back 998

21-hydroxylase deficiency (95% of cases), 11 b-hydroxylase deficiency, 3 b-hydroxysteroid dehydrogenase isomerase deficiency

Front 999

hirsutism:lab levels if abnormal

Back 999

DHEA > 8000 ng/ml or serum testosterone > 2 ng/ml

Front 1000

PCOS:labs

Back 1000

LH hypersecretion, Prolactinemia

Front 1001

CAH:labs

Back 1001

#VALUE!

Front 1002

PCOS:tx

Back 1002

Glucophage

Front 1003

PCOS:glucophae tx: avoid in who?

Back 1003

pts with kidney or liver dz

Front 1004

Generalized Congenital Hypertrichosis Lanuginosa:can be acquired in utero. How?

Back 1004

fetal hydantoin and fetal alcohol syndrome

Front 1005

Ambras Syndrome:3 things

Back 1005

hair on face, facial dysmorphism, dental anomalies

Front 1006

nails:Rates of growth: fingernail – ?mm/mo., toenail – ?mm/mo.

Back 1006

Rates of growth: fingernail – 3mm/mo., toenail – 1 mm/mo.

Front 1007

Absent lunula:

Back 1007

multiple myeloma, yellow nail syndrome

Front 1008

anonychia:

Back 1008

nail patella, coffin-siris, a couple weird onychodystrophy syndromes

Front 1009

Blue lunula:

Back 1009

Wilson’s, argyria, hemochromatosis, ochronosis

Front 1010

Blue lunula:drugs

Back 1010

busulfan, quinacrine, mercury followed by sunlight, AZT, antimalarials, minocin, silver nitrate, phenolphthalein, PUVA, 5FU, blacks (normal variant)

Front 1011

nails:Darier’s disease

Back 1011

v- nicking, alternative red/white longitudinal bands

Front 1012

nails:dolichonychia…what is it

Back 1012

long nails

Front 1013

nails:dolichonychia…in who?

Back 1013

the ehlers, marfans grouping

Front 1014

nails:what is elkonyxis

Back 1014

large pits

Front 1015

Habit tic:trauma to what?

Back 1015

cuticle

Front 1016

heller's median canaliform dystrophy:trauma to what?

Back 1016

proximal nail

Front 1017

koilonychia:list some inherited dzs

Back 1017

LEOPARD, ED, PIBIDS

Front 1018

koilonychia:list some acquired forms

Back 1018

plummer-vinson, hemochromatosis

Front 1019

Lindsays:half and half…caused by

Back 1019

chronic renal failure

Front 1020

Mee’s lines:causes

Back 1020

arsenic, RF, leprosy, any systemic dz

Front 1021

lindsays:true or not?

Back 1021

nail bed edema

Front 1022

Melanonychia striata:drug

Back 1022

AZT, minocin?

Front 1023

Muehrcke’s lines:systmic dz

Back 1023

nephrotic syndrome, low albumin, liver dz

Front 1024

Muehrcke’s lines:true or not?

Back 1024

no

Front 1025

Mee’s lines:true or not?

Back 1025

yes, true leukonychia

Front 1026

Onychomadesis:what is it

Back 1026

shedding of nail, beginning proximally

Front 1027

pachyonychia:which variant has amyloid?

Back 1027

type IV

Front 1028

Plummer’s nails:caused by

Back 1028

Onycholysis from hypothyroidism

Front 1029

Dorsal pterygium:seen in

Back 1029

LP, crosclerosis, Lesch-Nyan, GVHD

Front 1030

Ventral pterygium::aka

Back 1030

pterygium inversum unguis

Front 1031

Ventral pterygium::seen in

Back 1031

Systemic sclerosis, congenital

Front 1032

Red lunulae:seen in

Back 1032

AA, CTD, carbon monoxide, AZA

Front 1033

Terry’s nails:what is it

Back 1033

All BUT distal 2mm evenly white

Front 1034

Terry’s nails:seen in

Back 1034

cirrhosis

Front 1035

Lateral invasion + paronychia:organisms

Back 1035

Hendersonla toruloidea, scatylidium hyalinum

Front 1036

Armadillo Family:Plaque proteins that function in adhesion, name some

Back 1036

b-catenin, plakoglobin, plakophilin

Front 1037

desmosomes :have what 3 common proteins in all desomosomes

Back 1037

desmoplakin, plakoglobin, plakophilin, then either dsg1 or 3 or desmocollin depending on level

Front 1038

desmosomes :unique components, dependent on level

Back 1038

desmocollin, dsg 1(160) dsg 3(130)

Front 1039

mutation:desmoglein 1

Back 1039

striate ppk type 1

Front 1040

mutation:E-cadherin

Back 1040

gastric cancer

Front 1041

autoimmunity:desmoglein 1

Back 1041

pf, ritters

Front 1042

autoimmunity:dsg 1,3

Back 1042

pv

Front 1043

autoimmunity:dsg 3 only

Back 1043

mucosal pv

Front 1044

mutated in lamellar ichthyosis:

Back 1044

Transglutaminase 1:

Front 1045

antigen for dermatitis herpetiformis:

Back 1045

Transglutaminase 3:

Front 1046

Intermediate Filaments (IF):Type I (k#s and chromosome)

Back 1046

acidic keratins 9-20, chromosome 17

Front 1047

Intermediate Filaments (IF):Type II (keratins and chromosomes)

Back 1047

basic keratins 1-8, chromosome 12

Front 1048

Intermediate Filaments (IF):Type III

Back 1048

vimentin, glial fibrillary acidic protein (GFAP), desmin, peripherin

Front 1049

Intermediate Filaments (IF):Type IV

Back 1049

neurofilaments

Front 1050

Intermediate Filaments (IF):Type V

Back 1050

nuclear lamins

Front 1051

mutations in:keratin 1

Back 1051

.ichthyosis hystrix

Front 1052

mutations in:keratins 1/10

Back 1052

epidermolytic hyperkeratosis (EHK)

Front 1053

mutations in:keratins 1/16

Back 1053

nonepidermolytic PPK

Front 1054

mutations in:keratin 2e

Back 1054

ichthyosis bullosa of Siemens

Front 1055

mutations in:keratins 3/12

Back 1055

corneal dystrophy of Meesmann

Front 1056

mutations in:keratins 4/13

Back 1056

white sponge nevus of Cannon

Front 1057

mutations in:keratins 5/14

Back 1057

.epidermolysis bullosa simplex variants

Front 1058

mutations in:keratins 6a/16

Back 1058

pachyonychia congenita type 1

Front 1059

mutations in:keratins 6b/17

Back 1059

.pachyonychia congenita type 2

Front 1060

mutations in:keratin 9

Back 1060

.epidermolytic PPK

Front 1061

mutations in:lamin a

Back 1061

progeria

Front 1062

left ventricular cardiomyopathy with woolly hair and striate PPK:mut

Back 1062

desmoplakin1

Front 1063

target::desmoplakin I and II

Back 1063

.Stevens-Johnson syndrome

Front 1064

Adherens Junction:what proteins

Back 1064

E-cadherin, P-cadherin, alpha- and beta-catenin, vinculin and radixin; also plakoglobin like desmosomes

Front 1065

where are these weird proteins?:desmocalmin (keratocalmin), desmoyokin, band 6 protein

Back 1065

in the desmosome

Front 1066

Focal Contact:proteins

Back 1066

integrins, vinculin

Front 1067

Hemidesmosome:Cell membrane spanners:

Back 1067

alpha6beta4-integrin, Bullous Pemphigoid Antigen 2 (BPAg2 = type XVII collagen)

Front 1068

GABEB:now non-herlitz JEB or JEB mitis (vs letalis). Defect

Back 1068

BPAG2

Front 1069

JEB:herlitz mut

Back 1069

Lam 5

Front 1070

EBS:with muscular dystrophy

Back 1070

plectin

Front 1071

herpes gestationis:target

Back 1071

BPAg2-NC16A

Front 1072

.cicatricial pemphigoid:target

Back 1072

BPAg2-C terminal domain, laminin 5

Front 1073

Contains entactin (nidogen) in a complex with collagen IV:what is it?

Back 1073

lamina dense

Front 1074

Bullous Pemphigoid (BP):?% have oral involvement;

Back 1074

20%

Front 1075

Bullous Pemphigoid (BP):IgG subtype

Back 1075

IgG4

Front 1076

Drug-induced BP::classically cited inciting drug

Back 1076

lasix

Front 1077

Drug-induced BP::classically cited inciting drug is lasix, but ___ drugs and __-containing drugs may be more common; like?

Back 1077

sulfa…thiol. (thiol: captopril, penicillamine, gold thiosulfate)

Front 1078

Drug-induced BP::Two other disorders can present clinically like BP but have different target autoantigens, they are?

Back 1078

anti p105, anti p200

Front 1079

Chronic Bullous Disease of Childhood (CBDC):target

Back 1079

97 kDa antigen that is a part of BPAg2

Front 1080

Chronic Bullous Disease of Childhood (CBDC):course

Back 1080

disease tends to resolve spontaneously,

Front 1081

cictricial p:targets in form with mucosal and skin lesions:

Back 1081

BPAG2. form associated with malignancy: laminin 5 (=epiligrin, BM600, kalinin, nicein)

Front 1082

cictricial p:ocular form:

Back 1082

B4 integrin

Front 1083

cictricial p:form associated with malignancy:

Back 1083

laminin 5

Front 1084

Drug-induced CP::drugs

Back 1084

like BP. Sulfa and thiol-containing

Front 1085

CP :almost all have mucosal. If it doesn’t?

Back 1085

Brunsting-Perry pemphigoid:

Front 1086

DH:HLA types

Back 1086

DQ2, B8, DR3

Front 1087

DH:what % have abnormal jejunal bx?

Back 1087

90%

Front 1088

EB simplex:types

Back 1088

Weber cockayne; koebner; dowling meara

Front 1089

hemidesmosomal EB:

Back 1089

GABEB (bpag2), plectin (ebs with MD)

Front 1090

enamel hypoplasia is more characteristic of:which eb subtypes

Back 1090

JEB

Front 1091

EB:exuberant granulation tissue charactersitic of which subtype

Back 1091

herlitz JEB

Front 1092

EB:clumped tonofilaments are seen on electron microscopy in the __ subtype of EB

Back 1092

downling meara

Front 1093

EB:recessive dystrophic EB is secondary to a what kind of mutation exactly

Back 1093

premature stop codon

Front 1094

HG:onset

Back 1094

second or third trimester or postpartum period

Front 1095

HG:effects on Neonate

Back 1095

may be premature or be small for gestational age;

Front 1096

HG:75% of patients have a circulating HG factor

Back 1096

just know it

Front 1097

Linear IgA Disease:target

Back 1097

LAD-1) (97 kDa) (part of BPAG2)

Front 1098

Linear IgA Disease:drug induced

Back 1098

vancomycin amiodarone, lasix, IL2, IFN gamma, phenytoin, atorvastatin

Front 1099

PP:targtes

Back 1099

500 desmo (250) BPAG1 (230) envo (210) peri (190) unknown (170) DSG1 (160) DSG 3 (130)

Front 1100

PP:cancers

Back 1100

non-Hodgkin’s lymphoma (42%), chronic lymphocytic leukemia (CLL), Castleman’s (6%), sarcoma (6%), thymoma (6%)

Front 1101

PP:

Back 1101

#VALUE!

Front 1102

PF:why don’t neonates get it often?

Back 1102

they have dsg3 support in upper epidermis, like adult oral mucosa.

Front 1103

Pemphigus Vegetans:2 types:

Back 1103

Neumann type, Hallopeau type (begins with pustules);

Front 1104

PV:IIF

Back 1104

monkey

Front 1105

porphyrias:nm; gallstones associated with

Back 1105

erythropoietic protoporphyria;

Front 1106

porphyrias:no porphyrins in urine in

Back 1106

erythropoietic protoporphyria;

Front 1107

Acropustulosis of Infancy:onset usually

Back 1107

3–6 months,

Front 1108

Acropustulosis of Infancy:disappears by age

Back 1108

3-4 years old;

Front 1109

Hertoghe’s:

Back 1109

thinning of lateral eyebrows in atopic dermaitits

Front 1110

only milia of newborn:

Back 1110

crystallina. The only miliaria of newborn as it take several days to get miliaria rubra

Front 1111

Transient Neonatal Pustular Melanosis:lasts

Back 1111

1-2 weeks?

Front 1112

Gold:Patients allergic to gold often also react to

Back 1112

nickel and cobalt

Front 1113

Imidazolidinyl Urea:aka

Back 1113

Germall 115 = Tristat

Front 1114

Imidazolidinyl Urea:what is it

Back 1114

A preservative, a formaldehyde-releaser

Front 1115

Imidazolidinyl Urea:Cross-reacts with

Back 1115

formaldehyde and diazolidinyl urea

Front 1116

Methylchloroisothiazinolone:aka

Back 1116

Kathon CG = 5-chloro-2-methyl-4-isothiazolin-3-one

Front 1117

common allergen in leg ulcers:

Back 1117

lanolin

Front 1118

Neomycin:Cross-reactivity with other

Back 1118

aminoglycosides; allergy to bacitracin often coexists

Front 1119

Para-Phenylenediamine:found in

Back 1119

dyes, inks, photodeveloping solutions, textile dyes

Front 1120

Para-Phenylenediamine:Cross-reactivity with

Back 1120

azo- and aniline dyes, procaine, benzocaine,

Front 1121

Para-Tert-Butylphenol Formaldehyde Resin:Found in

Back 1121

shoes, watch straps, do-it-yourself glues, plywood, insulation,

Front 1122

Quaternium-15:acts as a

Back 1122

A preservative, a formaldehyde-releaser

Front 1123

Rosin (Colophony):A.k.a.

Back 1123

abietic acid

Front 1124

Thimerosal:Preservative in

Back 1124

vaccines (e.g. hepatitis), eyedrop solutions, cosmetics, nasal sprays

Front 1125

Thimerosal:Cross-reactivity with (2)

Back 1125

piroxicam. Also mercury or due to the thiosalicylic acid component

Front 1126

Thiuram Mix:found in

Back 1126

rubber (prevents degradation),

Front 1127

Includes garlic, onions, chives:

Back 1127

Family Alliaceae

Front 1128

Most important allergen in garlic is:

Back 1128

diallyl disulfide

Front 1129

Causes black dot dermatitis:

Back 1129

pentadecacatechol

Front 1130

celery, fennel, hogweed, parsnip:

Back 1130

Apiaceae

Front 1131

fig tree:

Back 1131

Moraceae

Front 1132

Rutaceae:

Back 1132

citrus (lime, bergamot orange, lemon, rue)

Front 1133

These families can cause phototoxicity:

Back 1133

apiaceae, moraceae, rutaceae

Front 1134

Clinically see chronic lichenification of face/neck/hands/arms (light-exacerbated):a plant family

Back 1134

Family Asteraceae

Front 1135

Family Asteraceae:Allergen is

Back 1135

sesquiterpene lactone

Front 1136

lavender, thyme, spearmint:

Back 1136

Family Lamiaceae

Front 1137

spearmint (:allergen

Back 1137

carvone

Front 1138

Spandex contains:

Back 1138

mercaptobenzathiazole

Front 1139

acid permanent waves:allergen

Back 1139

Glyceryl thioglycolate

Front 1140

dermatitis near nails:

Back 1140

Tosyl sulfonamide formaldehyde resin and ethyl acrylate

Front 1141

tests for Class A corticosteroid allergy:

Back 1141

Tixocortol pivalate

Front 1142

Class B and D corticosteroid allergy:

Back 1142

Budesonid

Front 1143

tea tree:name of plant

Back 1143

Melaleuca plant

Front 1144

Latex allergy – can cross-react with:

Back 1144

avocado, banana, chestnut, kiwi

Front 1145

irritant:Amaryllidaceae

Back 1145

calcium oxalate Includes daffodil, narcissus, hyacinth

Front 1146

Amaryllidaceae:

Back 1146

Includes daffodil, narcissus, hyacinth

Front 1147

Araceae:

Back 1147

dumb cane plant (Dieffenbachia),

Front 1148

dumb cane plant (Dieffenbachia),:irritant

Back 1148

calcium oxalate

Front 1149

croton plant, spurges:

Back 1149

Euphorbiaceae

Front 1150

Euphorbiaceae:irritant

Back 1150

phorbol esters

Front 1151

Ranunculaceae:includes

Back 1151

buttercups and marigolds

Front 1152

Ranunculaceae:irritant

Back 1152

protoanemonin (buttercups and marigolds)

Front 1153

visible light:wavelengths

Back 1153

400-760 nm).

Front 1154

The red portion is at the upper/lower end of the visible spectrum:

Back 1154

upper (760)

Front 1155

UVB converts __ in the skin to previtamin D:

Back 1155

7-dehydrocholesterol

Front 1156

__ in natural sunlight is the main contributor to erythema.:

Back 1156

UVB

Front 1157

Immediate pigment darkening fades within minutes after exposure. It is brought on by:

Back 1157

UVA and visible light.

Front 1158

Delayed tanning becomes visible about 72 hrs after __ exposure.:

Back 1158

UVB…. UVA contributes to a lesser extent

Front 1159

which is more efficient at inducing DNA damage? UVA or UVB:

Back 1159

UVB B for bad

Front 1160

most effective in producing pyrimidine dimers,:UVA or UVB

Back 1160

UVB

Front 1161

pmle versus solar urticaria:onset

Back 1161

hours for urticaria, days for pmle

Front 1162

Fluorescent UVA bulbs used for phototesting or PUVA therapy have a peak emission at:

Back 1162

352

Front 1163

renal trqnsplant fold incr risk for scc:

Back 1163

36

Front 1164

windows filter out what wavelength?:

Back 1164

uvb, not uva

Front 1165

pmle versus solar urticaria:uva or uvb or visible

Back 1165

uva and b

Front 1166

actinic purigo versus pmle?:

Back 1166

actinic pruigo begins in children, goes away by adolescence. May persist into the winter. Not as clearly related to sun exposire. Lesons are excoriated.

Front 1167

actinic pruigo:tx

Back 1167

thalidomide.

Front 1168

solar urticaria:spexctrum of reactivity

Back 1168

uva uv and visible

Front 1169

Chronic actinic dermatitis:sun exposed or protected

Back 1169

BOTH

Front 1170

Chronic actinic dermatitis:Some patients may show allergic contact dermatitis to what

Back 1170

the Compositae oleoresins.

Front 1171

photoallergy:classic chemical in soaps that used to cause it

Back 1171

halogenated salicylanilides,

Front 1172

photoallergy:common causes (4)

Back 1172

PABA, benzophenones, dibenzoylmethanes (parsol 1789), cinnamates

Front 1173

– Blue-gray pigmentation on sun-exposed areas –:drugs

Back 1173

amiodarone, chlorpromazine, TCAs

Front 1174

PUVA:most common psoralens used

Back 1174

8-MOP

Front 1175

PUVA:actual name brand used

Back 1175

oxaralen ultra (liqui filled caps)

Front 1176

PUVA:oxsoralen dose

Back 1176

0.4-0.6 mg/kg 1-1.5 hours before

Front 1177

contact urticaria:lisyt 3 families

Back 1177

hevea, aliaceae (esp celery), urtica dioica (stinging nettle), euphorbaciae (spurg nettle)

Front 1178

daffodils:family

Back 1178

narcissus

Front 1179

daffodils:cause?

Back 1179

irritant dermatitis (oxalates)

Front 1180

moast common cause of irritant dermatitis in florists:

Back 1180

daffodils…oxaltes

Front 1181

buttercup:family

Back 1181

ranunculaceae

Front 1182

poinsetta:family

Back 1182

euphorbiacaea (spurges also in this family)

Front 1183

euphorbiacaea:irritant (2)

Back 1183

phorbol esters, latex

Front 1184

irritant in:Ranunculaceae

Back 1184

Ranunculin

Front 1185

irritant in:Solanaceae

Back 1185

Chili pepper, Capsaicin

Front 1186

irritant and member of this family:Alliaceae

Back 1186

garlic, thiocyantes

Front 1187

irritant and member of this family:Brassicaceae

Back 1187

Mustard, radish, Thiocyanates like garlic

Front 1188

irritant and member of this family:Ananas comosus

Back 1188

pineapple, bromelin

Front 1189

irritant and member of this family:Lilaceae

Back 1189

hyacinth, ca oxalte

Front 1190

colophony :comes from

Back 1190

Pinus palustris tree

Front 1191

colophony :found in

Back 1191

Rosin, medications,mascara, adhesives,bandages, varnish, wax, paper products, dental cement

Front 1192

Alliaceae:members, allergen

Back 1192

garlic, onion, chive. Diallyl disulfide (thiocyante is an irritant)

Front 1193

“strimmer dermatitis”:causes

Back 1193

cow parsley, wild chervil, hogweed)

Front 1194

4 families phytophoto:

Back 1194

apiaceae, rutaceae, moraceae, fabaceae

Front 1195

Moraceae:

Back 1195

fig tree

Front 1196

Fabaceae (Leguminosae):

Back 1196

scruf pea

Front 1197

orf:length

Back 1197

6 weeks

Front 1198

erysilpeothix:kind of bacterium

Back 1198

grm negative rod

Front 1199

erysilpeothix:most commonl what farm animal

Back 1199

pigs

Front 1200

anthrax:the majority of naturally occuring dz is what form

Back 1200

cutaneous

Front 1201

anthrax:culture tip

Back 1201

with dacron tips

Front 1202

Cat-Scratch Disease:organism

Back 1202

b henselae

Front 1203

Cat-Scratch Disease:what can happen around the eye

Back 1203

LAD, conjuctivitis: occuloglandular sx of parinaud

Front 1204

Bacillary Angiomatosis:organism

Back 1204

b henselae

Front 1205

Brucellosis:aka

Back 1205

malta fever

Front 1206

Brucellosis:kind of bacterium

Back 1206

grm neg rod

Front 1207

glanders:tx

Back 1207

surgical excision

Front 1208

glanders:lymphatic drainage route called

Back 1208

farcy buds

Front 1209

dog versus cat bites:orgnism

Back 1209

p. mulocida (cats) dogs: P. canis

Front 1210

Lycosidae:spider, toxin

Back 1210

wolf, histamine

Front 1211

hidippus:spider, toxin

Back 1211

jumping, hyaluronidase

Front 1212

hobo spider:name

Back 1212

Tegenaria agrestis

Front 1213

Megalopyge opercularis:

Back 1213

puss caterpillar),

Front 1214

The venom from honeybee contains:

Back 1214

phospholipase A.

Front 1215

Black flies are vectors for:

Back 1215

onchocerciasis and tularemia.

Front 1216

Anopheles causes :

Back 1216

malaria.

Front 1217

Aedes causes :

Back 1217

yellow fever and dengue.

Front 1218

Mosquitoes prefer :

Back 1218

black skin, young skin, warm to cool skin, and scented skin. bright colors and elevated carbon dioxide concentrations.

Front 1219

Pulex irritans,:

Back 1219

The human flea,

Front 1220

Romana’s sign:

Back 1220

is unilateral eyelid swelling at the site of the bite of the assassin bug.

Front 1221

Lytta vesicatoria,:

Back 1221

the spanish fly or blister beetle

Front 1222

Lytta vesicatoria,:what is derived from it?

Back 1222

cantharadin

Front 1223

head lice:Resistance patterns have led to decreased efficacy of

Back 1223

permethrin 5% cream, pyrethrins, and lindane.

Front 1224

head lice:if resistant, use what

Back 1224

Malathion 0.5% continues to be effective.

Front 1225

Maculae cerulea can be seen in severe cases:

Back 1225

pubic lice

Front 1226

live in the folds of clothing,:

Back 1226

Pediculus humanus var. corporis, or body lice,

Front 1227

United States Ticks:list 5

Back 1227

Ixodes scapularis (aka dammini), I. pacificus, Ambylomma americanum, D. andersonii, D. variabilis

Front 1228

Lyme Disease::onset of the classic erythema migrans eruption.

Back 1228

Approximately 7 to 14 days incubation

Front 1229

Southern Tick-Associated Rash Illness::tick

Back 1229

lone-star tick, Amblyomma americanum,

Front 1230

Tick Paralysis::tick

Back 1230

Dermacentor

Front 1231

Tick Paralysis::lower motor neuron paralysis occurring

Back 1231

4–7 days after attachment,

Front 1232

Babesiosis: caused by intracellular RBC parasite, Babesia microti; transmitted by larvae of:

Back 1232

I. Dammini.

Front 1233

Erlichiosis:tick

Back 1233

I scapularis (dammini)

Front 1234

Lyme Borreliosis:organism

Back 1234

Borrelia burgdorferi

Front 1235

Lyme Borreliosis:vectors

Back 1235

Ixodes dammini, I. pacificus, Amblyomma americanum (lone star)

Front 1236

Relapsing Fever:organisms

Back 1236

Borrelia duttonii, B. hermsii,

Front 1237

Relapsing Fever:vectors

Back 1237

Ornithodoros moubata

Front 1238

RMSF:organism

Back 1238

r rickettsia

Front 1239

RMSF:vectors

Back 1239

D. andersoni, D variabilis, A. americanum

Front 1240

Tularemia:organism

Back 1240

F. tularensis

Front 1241

Tularemia:vectors

Back 1241

D andersoni, D variabilis

Front 1242

Ehrlichiosis:tick

Back 1242

rhipicephalus sanguineus

Front 1243

Dermanyssus is the most common class.:of?

Back 1243

fowl mites

Front 1244

glyciphagus:?

Back 1244

cheese mite

Front 1245

Acarus:?

Back 1245

grain mite

Front 1246

Trombicula:

Back 1246

chigger (harvest mite)

Front 1247

vector of rickettsial pox.:-2

Back 1247

Ornithonyssus bacoti (tropical rat mite), and Allodermanyssus sanguineus (housemouse mite)

Front 1248

baker’s itch:

Back 1248

Acarus (grain mite)

Front 1249

carriers:Hedgehogs

Back 1249

Trichophyton mentagrophytes. European hedgehogs may transmit M. marinum or M. avium-intracellulare.

Front 1250

carriers:flying squirrel,

Back 1250

Toxoplasma gondii, r. prowazekii (epidemic typhus)

Front 1251

carriers:chinchilla

Back 1251

Trychophyton mentagrophytes, Microsporum gypseum,

Front 1252

carriers:cockatoo

Back 1252

Cryptococcus neoformans

Front 1253

jellyfish, Portuguese man of war, sea anemones, coral, hydrozoa:family

Back 1253

Cnidarians

Front 1254

hydrozoa:a member of this cnidarian group

Back 1254

Portuguese man of war

Front 1255

nematocysts in jellyfish:"fix" them so they don’t fire anymore

Back 1255

vinegar

Front 1256

Cutaneous Larvae Migrans:dogs

Back 1256

Ancylostoma caninum

Front 1257

Cutaneous Larvae Migrans:cats

Back 1257

A braziliensis

Front 1258

source:Anthralin

Back 1258

Vouacopoua araroba tree.

Front 1259

source:Antimalarials

Back 1259

Cinchona officinalis in Lojan rainforests.

Front 1260

source:Cantharadin

Back 1260

Lytta vesicatoria (blister beetle). Aka spanish fly

Front 1261

source:Pyrethrin

Back 1261

chrysanthemum flower (compositae family).

Front 1262

? of patients allergic to penicillins may also exhibit similar allergic reactions to cephalosporins5

Back 1262

10

Front 1263

has been associated with an increased incidence of serum sickness in children6 (cephalosporin)

Back 1263

cefaclor

Front 1264

products, calcium, and iron or zinc salts7

Back 1264

tet more than doxy/mino

Front 1265

the only tetracycline for use in patients with renal failure8

Back 1265

doxy

Front 1266

tetracyclins: which is most common causes of fixed drug eruption

Back 1266

tet

Front 1267

the most phototoxic of all the tetracyclines. the most phototoxic of all the tetracyclines.

Back 1267

Demeclocycline and doxycyclin

Front 1268

Macrolides list em

Back 1268

CELL...clarithro, erythro, azithro, some Ls

Front 1269

abx: Cholestatic hepatitis is associated with

Back 1269

EES

Front 1270

abx: Fluoroquinolones spectrum, specifically

Back 1270

Mycobacterium species, gram-negative infections, particularly Enterobacteriaceae

Front 1271

abx: fluoroquinolones absorbed better or worse with antacids?

Back 1271

worse.

Front 1272

abx: Only drug bactericidal to M. leprae

Back 1272

Rifampin

Front 1273

abx: clindamycin MOA

Back 1273

50s

Front 1274

abx: macrolide mOA

Back 1274

50s

Front 1275

abx: Clindamycin spectrum

Back 1275

Particularly effective against anaerobic and gram-positive organisms,

Front 1276

which tetracyclin is impaired by the ingestion of dairy

Back 1276

tatrecycline

Front 1277

has been associated with an increased incidence of serum sickness in children6 (cephalosporin)

Back 1277

cefaclor

Front 1278

products, calcium, and iron or zinc salts7

Back 1278

tet more than doxy/mino

Front 1279

the only tetracycline for use in patients with renal failure8

Back 1279

doxy

Front 1280

tetracyclins: which is most common causes of fixed drug eruption

Back 1280

tet

Front 1281

the most phototoxic of all the tetracyclines. the most phototoxic of all the tetracyclines.

Back 1281

Demeclocycline and doxycyclin

Front 1282

Macrolides list em

Back 1282

CELL...clarithro, erythro, azithro, some Ls

Front 1283

abx: Cholestatic hepatitis is associated with

Back 1283

EES

Front 1284

abx: Fluoroquinolones spectrum, specifically

Back 1284

Mycobacterium species, gram-negative infections, particularly Enterobacteriaceae

Front 1285

abx: fluoroquinolones absorbed better or worse with antacids?

Back 1285

worse.

Front 1286

abx: Only drug bactericidal to M. leprae

Back 1286

Rifampin

Front 1287

abx: clindamycin MOA

Back 1287

50s

Front 1288

abx: macrolide mOA

Back 1288

50s

Front 1289

abx: Clindamycin spectrum

Back 1289

Particularly effective against anaerobic and gram-positive organisms,