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10 Cards in this Set
- Front
- Back
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Mimivirus "Mimicking microbe" |
First giant virus discovered. Found in Amoebae. Isolated from A. polyphaga. Icosohedral capsid. Enveloped. 400 nm (comparable to small bacteria). Linear dsDNA genome. |
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Mimivirus replication |
Replicates in cytoplasm. Orchestrated by its own genes. |
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Mimivirus phylogeny |
based on 8 conserved viral proteins. |
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Megavirus |
Related to Mimivirus. 77% of genes have homolog to Mimivirus. 6.5% larger genome than Mimivirus. |
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Divergence between Mega and Mimivirus |
Primarily due to accumulation of point mutations.
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Genes unique to one or the other usually found |
clustered near the ends of the chromosome |
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The genomes also differ in |
expansion or reduction of paralogous gene families. |
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Stargate structure |
Found in both Mimi and Megavirus. At the vertex of the capsid. Structure opens allowing the release of viral DNA into the host cytoplasm. |
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1st hypothesis of Mimiviridae origin. |
Large genomes are a result of extensive transfer from host, bacteria, and other viruses |
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2nd hypothesis of Mimiviridae origin. |
Most genes originated from and even more complex viral ancestor, itself derived from and ancestral cellular genome. |
