Gi_Pm_Pharma_Anti-Eukaryotes

Front 1

What are the Non-misc. Anthelmintics (anti helminths) end with

Back 1

"bedazoles"

Front 2

What are the 3 benddazole (anthelmintics)

Back 2

Bezimidazoles:
Albendazole
Mebendazole
Thiabendazole (cutaneous)

Front 3

What are the 3 miscellaneous Anthelmintics

Back 3

Ivermectin
Praziquantel
Pyrentel pamoate

Front 4

What is suspected MOA of Benzimidazole(s)

Back 4

Inbx Microtubule via beta-tubulin binding
--> Decrease of Glucose Transport
Ibx of Mitochondrial Fumarate reductase
==Immobilize Worm = death

Front 5

How efficacious are Benzimidazoles for worms

Back 5

VERY, 1x dose for most
--Albendazole is even more effect---most COMMONLY Selected
--Thiabendazole is limited use due to toxicity--cutaneous only

Front 6

Which misc anthelmintic binds selectively with high affinity to GLutamate-Gated Cl- ion channels

Back 6

Ivermectin (misc.)
--Induces hyperpolarization resulting in tonic paralysis of the worms

Front 7

How efficacious is Ivermectin as an Anthelmintec

Back 7

Good with single dose
-PRoduces Massive muscular contraction of worm that results in paralysis and eath

Front 8

What does Praziquantel do

Back 8

Inc cell mem perm.= Intracellular Calcium
-Causes MASSIVE contractions, ends in paralysis of mm.=death
--disintigeration of schistosome tegument
---Efficacy seen in single doses OR 3 dose regime

Front 9

Which drug is a depolarizing neuromuscular blocker

Back 9

Pyrntel pamoate
--another anthelmintec
--Opens Non-selective cation channels = Stims release of Acetylcholin = MASSIVE muscular contractions that lead to paralysis and death
(like succinyl choline--cause mm. contraction until mm. waste energy = paralysis)

Front 10

what is efficacy of pyrantel pamoate

Back 10

very good, 1x does for most worms, more if heavy infection

Front 11

moving on to

Back 11

Anti-Protozoals
--2 are ALSO antibacterial

Front 12

What family of Antiobiotic s is teh Paromomycin, used as an Anit-Protozoals (AnProt)?

Back 12

Aminoglycoside
--ibx 30s ribosomal
--note used as antibiotic as other aminoglycs are---its anti-protozoa

Front 13

What is Metronidazoles sister drug?
What is MOA for both?

Back 13

Tinidazole

-Prodrug, activated by electron trans chain, creates nitro-radicals disrupting DNA

Front 14

What are AE of Metronidazole & Tinidazole

Back 14

Metallic Taste--M for Metro
-Disulfiram-like reaction
---severe Sx with ETOH intake
--GI distress

Front 15

How do Atovaquone-Proguanil work?

Back 15

Atovaquone interferes with Mito ATP activity
-Proguanil ibx some weird proteins

Front 16

What is MOA for Mefloquine and Chloroquine
--efficacious

Back 16

MOA unknown--suggest Nucleic Acid dysruption
--somehow kills the Protazoa
--works, but limited due to Toxicity

Front 17

What Anti-Prota is an alkaloid naturally occuring

Back 17

Quinine
-from Cinchona Tree

Front 18

What is MOA for Quinine?

Back 18

Unknown--elevates pH of vesicles

Front 19

Pyrimethamine-Sulfadoxine
--what are separate MOAs of this

Back 19

Pyrimethamine--works similar to many antibiotics with dihydrofolate reductase (FOlic Acid Ibs)--ie, Trimethoprim-aka Bactrim--

Sulfadoxin--ibx bacterial dihydropteroate synthase--intereferes with PABA-p aminobenzoic acid--needed for folic acid

Front 20

Moving on to Drug of Choice per

Back 20

the Type of Infection/Organism
--Give primary drug per organism listed (backup listed just fyi--DONT need to know both)

Front 21

For Amebiasis: Entamoeba histolytica

Back 21

Metronidazole followed by paromomycin

Front 22

Hookworm:
Ancylostoma duodenale
Necator americanus

Back 22

Al or Me
-albendazole,
Or Mebendazole

Front 23

Roundworm:
Ascaris lumbricoides

Back 23

Al or Me
Albendazole or Mebendazole

Front 24

Babesiosis:
Babesia microti

Back 24

Atovaquone + Azithromycin

Front 25

Filariasis:
Wuchereria bancrofti,
Brugia malyi,
Brugia timori,
Loa Loa

Back 25

Diethylcarbamazine
--CDC issues only

Hint 25

again, Filariases:
Filariasis:
Wuchereria bancrofti,
Brugia malyi,
Brugia timori,
Loa Loa

Front 26

Filiariasis:
Onchocerca volvulus (river blindness)

Back 26

Ivermectin
-Use WITH Albendazole fo Lymphatic Filariasis

Front 27

Tapeworm-ADULT forms
Diphyllobothrium latum
Taenia saginata
Taenia solium
Dipylidium caninum

Back 27

Praziquanel

Front 28

Tapeworm-LARVAl forms:
Echinococcus granulosus
Taenia solium

Back 28

Al
Albendazole

Front 29

Pinworm;
Enterobius vermicularis

Back 29

Me
Mebendazole

Front 30

Clonorchis sinensis
Fasciolopsis buski
Heterophyes herophyes
Metagonimus yokgawai
Metorchis conjunctus
Nanophyetus salmincola
Opisthorchis viverrini
Paragonimus westermni
all ar what?

Back 30

Flukes

Front 31

Flukes:

Back 31

Praziquantel

Hint 31

Clonorchis sinensis
Fasciolopsis buski
Heterophyes herophyes
Metagonimus yokgawai
Nanophyetus salmincola
Opisthorchis viverrini
Paragonimus westermni

Front 32

Giardiasis:
Giardia duodenalis

Back 32

Metronidazole OR
Tinidazole

Front 33

Leishmaniasis:
Leishmania infantum
Leishmania donovani

Back 33

Amphotericin B (IV)

Paromomycin (PO)

Front 34

Lice/ Scabies:
Pediculus humanus
Pediculus capitis
Phthirus pubis

Back 34

Permethrin (Top)
Ivermectin (PO)

Front 35

Malaria:
Plasmodium falciparum
P. vivax
P. ovale
P. malariae

Back 35

Chloroquine OR
Mefloquine

Front 36

Malaria with Resistance?

Back 36

Atovaquone & Proguanil

Front 37

Microsporidiosis:
Encephalitozoon species

Back 37

AL
Albendazole

Front 38

Schistosomiasis:
Shistosoma sp.

Back 38

Praziquantel

Front 39

Threadworm:
Strongyloides stercoralis

Back 39

Ivermectin (PO)

Front 40

Toxoplasmosis:
Toxoplasma gondii

Back 40

Pyrimethamine & Sulfadiazine

Front 41

Trichinellosis:
Trichinella spiralis

Back 41

Al OR Me
Albendazole or Mebendazole + STEROIDs for collateral damage

Front 42

Trichomoniasis:
Trichomonas vaginalis

Back 42

Metronidazole or Tinidazole

Front 43

Whipworm:
Trichuris trichura

Back 43

Me
Mebendazole for tricky tricky

Front 44

Visceral Larva Migrans:
Toxocariasis

Back 44

Al & Me
-Albendazole or Mebendazole

Front 45

NO new information

Back 45

from here on
These are the same cards, but listed by drug

Front 46

What drug for these 3:
Hookworm
Roundworm
Tapeworm--Larval?

Back 46

Albendazole

Front 47

What drug for these 2:
Pinworms
Whipworms?

Back 47

Me
Mebendazole

Front 48

What drug for these 3:
Microsporidiosis
Trichinellosis
Visceral Larva Migrans

Back 48

Al
Albendazole

Front 49

What drug for these 3:
Schistosomiasis
Tapeworm--ADULT
Flukes

Back 49

Praziquantel

Front 50

What is Paromomycin used for
(an aminoglyc, 30s)

Back 50

Leishmaniasis

Front 51

What drug for these 3:
Strongyloidiasis--Threadworms (oral)
-Onchocerciasis--River blindness
Lice/Scabies (oral)

Back 51

Ivermectin

Front 52

What treats Toxoplasmosis? (2 drugs)

Back 52

Pyrimethamine AND Sulfadiazine

Front 53

What drug for these 3:
Trichomonas
Giardiasis
Amebiasis

Back 53

Metronidazole

Front 54

What do Chloroquine/Mefloquine treat

Back 54

Malaria:
P. vivax, P. ovale, P. malariae

Front 55

What do Atovaquone & Proguanil treat

Back 55

Babesiosis
Malaria (chloroquine-resistant falciparum)

Front 56

What's used to treat Lice/Scabies topical

Back 56

Permethrin

Front 57

What treats Oral Lice/Scabies?

Back 57

Ivermectin