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10 Cards in this Set
- Front
- Back
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Common features of viral hepatitis?
Lab findings? |
RUQ abd pain, nausea, anorexia, fatigue, fever, jaundice, hepatomegaly
elevated liver enzymes, bilirubin in blood/urine, Alk Phos, LDH |
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HAV:
Family of viruses? stable or unstable in environment? acute, chronic? asymptomatic, symptomatic? Transmission? Where? single outbreak or community? |
picornaviridae, +ssRNA, one serotype worldwide
stable in environment acute, asymptomatic infections "infectious hepatitis" fecal-oral, crowded, poor hygiene community outbreaks |
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Hep A pathogenesis?
definitive dx of acute infection? definitive dx of past infection? Tx of HAV? |
intestine --> hepatocytes (replication) --> feces
acute infection, >14 y/o anti-HAV IGM - acute infection anti-HAC IGG - past infection no antiviral tx, vaccinations, children @ 1 y/o, travelers |
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HBV:
Family? Transmission? How is the liver damaged? Who gets the active vaccine? Who gets the passive vaccine? |
hepadnaviridae, enveloped dsDNA
blood/semen, to liver liver damaged by immune response, not viral replication children, infants, high-risk health care workers |
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Hep B:
General serum marker of infection: Recovery/immunity to HBV: Marker of acute infection: Marker of past/chronic infection: active replication: |
general: HBsAg
Recovery/immunity: anti-HBsAb acute: anti-HBc IGM chronic: anti-HBc IGG active replication: HBeAg, HBV-DNA |
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Which hepatitis often co-infects with Hep B?
What type of virus? risk group? Serologic dx? |
Hep D
ssRNA, unclassified IVDA's and partners anti-HDV IGM, anti-HDV IGG, HDV Ag |
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Which hepatitis is not person-person transmitted?
Best way to prevent Hep E infection? |
Hep E
watch for contaminated H2O |
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Serum findings in active infections of Hep B?
Serum findings in recovery? Serum findings in chronic persistent? Chronic active? |
HBsAg, anti-HBcAg IGM
anti-HBsAg, anti-HBcAg IGG HBsAg, anti-HBcAg IGG, anti-HBeAg HBsAg+, HBeAg, HBcAg IGG, DNA Pol. |
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Hep C:
Family, type of virus? animal reservoir? Transmission? commonly causes _________ infections. leading cause of ______________. |
Flavivirus, +ssRNA
humans, chimps injection, needle stick, sexual chronic liver transplantation |
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Factors that promote progression/severity of Hep C:
Ability to clear virus depends on ______ response. |
EtOH, age, HIV, male, HBV
T-cell (CD4, CD8) |
