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11 Cards in this Set
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4 m/o infant presents with watery diarrhea, vomiting x 24 h. no PO intake, appears dehydrated:
Morphology? Which group most common? Why is its habitat unique? |
Rotavirus
dsRNA, Reoviridae A more common in temperate climates, circulates in winter months |
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What age group is most commonly affected?
What makes Rotavirus so hardy? What binds to glycolipids on the membrane of villus epithelial cells? |
6-24 mo.
no membrane, can remain for days on surfaces, wide pH survival, relatively resistant to cleaning/disinfectants capsid |
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S/S of Rotavirus?
Mortality from what? malabsorption of what? |
smelly poops, fever, nausea, diarrhea, watery diarrhea WITHOUT LEUKOCYTES, fever
dehydration fat, lactose |
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What virus can cause either respiratory or GI diseases?
Morphology? transmission? Where does it attack? |
adenovirus
dsDNA, non-enveloped droplets, fecal-oral, poorly chlorinated H2O mucoepithelial cells of conjunctiva, repiratory tract, GI, GU |
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People on a cruise develop GI symptoms with abd cramps, main symptom is vomiting, also diarrhea, malaise, HA. Disease lasted for 2-3 days:
what age groups does it affect more? any blood/leukocytes in stool? |
caliciviruses - Norwalk virus, Norwalk-like
adults, children > 4 y/o No blood or leukocytes |
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Where are caliciviruses often found?
Most common transmission? What causes "winter vomiting disease"? How do you dx? |
water - shellfish, contaminated food, lakes
contaminated food Noroviruses by exclusion, R/O everything else |
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What pathogens cause enteric disease in AIDS patients/immunosuppressed?
37 y/o homosexual male, vomiting, diarrhea, cramping, abd pain, no blood in stool, no leukocytes, intranuclear inclusions with halo: |
CMV, HSV, HIV
CMV |
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What groups are most at risk for CMV infection?
transmission of CMV? |
high income - 50%
low income - 85% homosexuals - 95% sexual, urine contact, transfusion/transplantation |
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Review:
DsRNA, 10-11 segments, non-enveloped: domestic/wild animals, outbreaks in closed environments - camps, cruises, schools: |
Rotavirus
Norwalk virus |
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serotypes 40,41 associated with diarrhea in infants:
most common cause of viral GE in industrialized countries, "winter vomiting disease": "summer diarrhea", often community outbreaks: |
Adenovirus
Norovirus Norwalk virus |
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affects immunocompromised, highest risk in homosexuals and low-income:
vaccine approved in 2006, mortality due to dehydration: |
CMV
Rotavirus |
