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6 Cards in this Set
- Front
- Back
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How to PPI's get to the parietal cells?
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They are absorbed into the intestines and move directly to the site of action
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True/False: PPI's block both active and inactive pumps.
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FALSE
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When should PPI's be administered? Why is this important? How long do they take to have an effect and how long does their effect last?
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An hour before food is consumed--this is because the pumps are turned on by eating..maximal effect is attained by taking 1 hr before
Effect lasts up to 24 hours because new pumps must be made and it may take up to 3 days to take effect because it only affects active pumps |
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What are some examples of H2 antagonists?
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Cimetidine, ranitidine, famotidine, nizatidine
Tagament, Zantac, Pepcid, and Axid |
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What is misoprostol's(cytotec) mechanism of action? What is it therefore used for?
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Prostaglandin analogue--bind to receptor on parietal cells to stimulate Gi pathway and decrease cAMP which decreases gastric acid secretion
Prevent gastric injury by stimulation of mucin and bicarb secretion and INCREASED MUCOSAL BLOOD FLOW |
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What are the two mechanisms for NSAID toxicity?
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The are absorbed across the gastric mucosa due to not being ionized at the pH found in the stomach
COX-1 is expressed in most tissues including the GI mucosa and NSAID's cause reversible COX-1 inhibition and this decreases PG activity leading to GI mucosal damage |
