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18 Cards in this Set
- Front
- Back
- 3rd side (hint)
Gastrin
Role? (2) |
1.) Parietal Cells to secrete HCl
2.) Gastric Motility Stimulus? (3) |
1.) AA in stomach
2.) PS stimulation w/ GRP neurotransmitter. 3.) Gastric Distention |
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CCK
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From I cells.
Stimulated by FFA and AA in duodenum. Slows gastric emptying, increase pancreatic secretions, contraction of gallbladder. Triggers satiety in brain. Potentiates Secretin. |
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Parietal Cells
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Secrete HCl and Intrinsic Factor upon vagal Ach stimulation, gastrin, and Histamine.
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Cheif Cells
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Secrete pepsinogen
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Secretin
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Act in response to FFA and H+ in Duodenum. Main effect is to neutralize lumen with pancreatic -HCO3.
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Somatostatin
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Inhibits everything. Found in D cells of Pancreas, Stomach. Secreted in response to glucose and glucagon.
Found in PVN of hypothalamus. Inhibits GHRH, GH, TSH. |
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GLP-1/GIP
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Incretins from duodenal L cells and K cells respectively.
Respond to FFA, AA, and glucose in SI. Inhibits secretion of Parietal Cell H+, Glucagon Stimulates Insulin. |
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Growth Factor
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Act through Tyrosine kinase to exert Mitogenic activity(cell differentiation, proliferation, and growth)
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Inhibition of PTH
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In cheif cells, Ca2+ decreases PTH secretion.
But also increases PTH processing. |
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Polyuria
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Large Volumes of Urine
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Can be attributed to diabetes insipidus, diabetes mellitus...
not enough- ALDO, K+, AVP too much- Ca2+, PTH, polydipsia(thirst), T3/T4 |
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Intrinsic Factor
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VitB12 Absorption
Allows synthesis of RBCs |
produced in Parietal Cells and acts at pH 7. Binds to VitB12 in duodenum so that it can be absorbed in terminal Illeum.
Inhibition of B12 reabsorption leads to pernicious anemia. |
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Glucagon
1.) Role? |
Glycogenolysis
Gluconeogenesis Lipolysis 2.) Stimulated by? |
Epi, high AA, Sympathetic Activity
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FGF
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Growth Factor that stimulates Angiogenesis
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Tumors need more vessels for growth. A possible drug that can be developed is an FGF receptor blocker.
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Laron dwarfism
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Decreased Growth as a result of insensitivity to GH because of a defective GH receptor.
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Treat with IGF-1
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Epi/NE effect on muscle metabolism
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Increase glycogenolysis.
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Working muscle breaks down glucose, non-working muscle breaks down glucose to lactate and pyruvate. These go to the liver to synthesize new glucose.
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Somatostatin
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Acts to inhibit cAMP production.
Opens K+ channels to hyperpolarize cells. Closes Ca2+ channels. |
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GH mechanism of action
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50% bound to GH receptor binding protein in plasma.
Acts through a Jak-Stat Tyrosine Kinase. In B-cells, block GLUT-4 from going to the membrane. |
anti-insulinic effect!
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Hypophysiotropic Hormones
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Release tropic hormones from AP.
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ex.) TRH, CRH, GHRH, SS, GnRH, DA, VIP, MSH, 5HT
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